Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in -βcell mass

Endocrinology

Volumn 155, Issue 3, 2014, Pages 726-735

  Cordoba Chacon, Jose ^a,b   Gahete, Manuel D ^a,b,c   Pokala, Naveen K ^a,b   Geldermann, David ^a,b   Alba, Maria ^d   Salvatori, Roberto ^d   Luque, Raul M ^c   Kineman, Rhonda D ^a,b  

^a JESSE BROWN VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CÓRDOBA   (Spain)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; BROXURIDINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA;

ADULT ONSET ISOLATED GROWTH HORMONE DEFICIENCY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA CELL FUNCTION; BETA CELL MASS; CELL FUNCTION; CONTROLLED STUDY; DETERIORATION; GENE EXPRESSION; GROWTH HORMONE DEFICIENCY; HYPERTRIGLYCERIDEMIA; IN VITRO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIPID DIET; LIPOTOXICITY; LOW FAT DIET; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PHENOTYPE; PRIORITY JOURNAL; WEIGHT, MASS AND SIZE;

ANIMALS; BROMODEOXYURIDINE; CELL PROLIFERATION; GLUCOSE; GROWTH HORMONE; HOMEOSTASIS; INFLAMMATION; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LIPID METABOLISM; LIPIDS; MALE; MICE; MICE, KNOCKOUT; PHENOTYPE; POSTPRANDIAL PERIOD; PPAR-BETA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, SOMATOTROPIN; TIME FACTORS;

EID: 84896898770     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1825     Document Type: Article

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