Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 3, 2012, Pages 1013-1019

  Oliveira, Carla R P ^a   Salvatori, Roberto ^b   Barreto Filho, Jose A S ^a   Rocha, Ivina E S ^a   Mari, Andrea ^c   Pereira, Rossana M C ^a   Campos, Viviane C ^a   Menezes, Menilsson ^a   Gomes, Elenilde ^a   Meneguz Moreno, Rafael A ^a   Araújo, Vanessa P ^a   Leite, Natália T F ^a   Nascimento, Adão C ^a   Farias, Maria I T ^a   Viscente, Thaisa A R ^a   Araújo, Raquel D C ^a   Melo, Enaldo V ^a   Aguiar Oliveira, Manuel H ^a  

^a FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH HORMONE RELEASING FACTOR RECEPTOR; INSULIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; FEMALE; GENE MUTATION; GHRH RECEPTOR GENE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HOMOZYGOSITY; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; ISOLATED GROWTH HORMONE DEFICIENCY; LIFESPAN; MALE; MORBIDITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR GENE;

EID: 84858031213     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-2590     Document Type: Article

References (34)

1. Ferrannini E, Mari A 2004β-Cell function and its relation to insulin action in humans: a critical appraisal. Diabetologia 47:943-956 (Pubitemid 38757009)
2. Twickler TB, Cramer MJ, Dallinga-Thie GM, Chapman MJ, Erkelens DW, Koppeschaar HP 2003 Adult-onset growth hormone deficiency: relation of postprandial dyslipidemia to premature atherosclerosis. J Clin Endocrinol Metab 88:2479-2488 (Pubitemid 36724412)
3. Clemmons DR 2004 The relative roles of growth hormone and IGF-I in controlling insulin sensitivity. J Clin Invest 113:25-27 (Pubitemid 38541628)
4. Liu JL, Coschigano KT, Robertson K, Lipsett M, Guo Y, Kopchick JJ, Kumar U, Liu YL 2004 Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab 287:E405-E413 (Pubitemid 39095873)
5. . Guo Y, Lu Y, Houle D, Robertson K, Tang Z, Kopchick JJ, Liu YL, Liu JL 2005 Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene deficient mice. Endocrinology 146:2602-2609 (Pubitemid 40703964)
6. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D 1999 Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 96:7324-7329 (Pubitemid 29299660)
7. Hew FL, Koschmann M, Christopher M, Rantzau C, Vaag A, Ward G, Beck-Nielsen H, Alford F 1996 Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthetase activity. J Clin Endocrinol Metab 81:555-564 (Pubitemid 26055663)
8. Gola M, Bonadonna S, Doga M, Giustina A 2005 Clinical review: growth hormone and cardiovascular risk factors. J Clin Endocrinol Metab 90:1864-1870 (Pubitemid 40464062)
9. Rosén T, Bengtsson BA 1990 Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336:285-288 (Pubitemid 20229130)
10. . Markussis V, Beshyah SA, Fisher C, Sharp P, Nicolaides AN, Johnston DG 1992 Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Lancet 340:1188-1192
11. Miller KK, Biller BM, Lipman JG, Bradwin G, Rifai N, Klibanski A 2005 Truncal adiposity, relative growth hormone deficiency, and cardiovascular risk. J Clin Endocrinol Metab 90:768-774 (Pubitemid 40279194)
12. Hannon TS, Danadian K, Suprasongsin C, Arslanian SA 2007 Growth hormone treatment in adolescent males with idiopathic short stature: changes in body composition, protein, fat, and glucose metabolism. J Clin Endocrinol Metab 92:3033-3039 (Pubitemid 47236367)
13. Yuen KC, Frystyk J, White DK, Twickler TB, Koppeschaar HP, Harris PE, Fryklund L, Murgatroyd PR, Dunger DB 2005 Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed ad- ministration of a very low growth hormone (GH) dose in adults with severe GH deficiency. Clin Endocrinol (Oxf) 63:428-436 (Pubitemid 41442337)
14. Ben-Shlomo A, Melmed S 2008 Acromegaly. Endocrinol Metab Clin North Am 37:101-122, viii
15. Salvatori R, Hayashida CY, Aguiar-Oliveira MH, Phillips 3rd JA, Souza AH, Gondo RG, Toledo SP, Conceicão MM, Prince M, Maheshwari HG, Baumann G, Levine MA 1999 Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene. J Clin Endocrinol Metab 84:917-923
16. Aguiar-Oliveira MH, Gill MS, de A Barretto ES, Alcântara MR, Miraki-Moud F, Menezes CA, Souza AH, Martinelli CE, Pereira FA, Salvatori R, Levine MA, Shalet SM, Camacho-Hubner C, Clayton PE 1999 Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J Clin Endocrinol Metab 84:4118-4126
17. Gleeson HK, Souza AH, Gill MS, Wieringa GE, Barretto ES, Barretto-Filho JA, Shalet SM, Aguiar-Oliveira MH, Clayton PE 2002 Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan. Clin Endocrinol (Oxf) 57: 89-95 (Pubitemid 34790229)
18. Barreto-Filho JA, Alcântara MR, Salvatori R, Barreto MA, Sousa AC, Bastos V, Souza AH, Pereira RM, Clayton PE, Gill MS, Aguiar-Oliveira MH 2002 Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia. J Clin Endocrinol Metab 87:2018-2023 (Pubitemid 34521484)
19. Oliveira CR, Salvatori R, Meneguz-Moreno RA, Aguiar-Oliveira MH, Pereira RM, Valença EH, Araujo VP, Farias NT, Silveira DC, Vieira JG, Barreto-Filho JA 2010 Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency. J Clin Endocrinol Metab 95:693-698
20. Menezes Oliveira JL, Marques-Santos C, Barreto-Filho JA, Ximenes Filho R, de Oliveira Britto AV, Oliveira Souza AH, Prado CM, Pereira Oliveira CR, Pereira RM, Ribeiro Vicente Tde A, Farias CT, Aguiar-Oliveira MH, Salvatori R 2006 Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone (GH) deficiency due to a GH releasing hormone receptor mutation. J Clin Endocrinol Metab 91:2093-2099 (Pubitemid 43854988)
21. Aguiar-Oliveira MH, Oliveira FT, Pereira RM, Oliveira CR, Blackford A, Valenca EH, Santos EG, Gois-Junior MB, Meneguz-Moreno RA, Araujo VP, Oliveira-Neto LA, Almeida RP, Santos MA, Farias NT, Silveira DC, Cabral GW, Calazans FR, Seabra JD, Lopes TF, Rodrigues EO, Porto LA, Oliveira IP, Melo EV, Martari M, Salvatori R 2010 Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene. J Clin Endocrinol Metab 95:714-721
22. Bismuth E, Laborde K, Taupin P, Velho G, Ribault V, Jennane F, Grasset E, Sermet I, de Blic J, Lenoir G, Robert JJ 2008 Glucose tolerance and insulin secretion, morbidity, and death in patients with cystic fibrosis. J Pediatr 152:540-545, 545.e1
23. Karlberg N, Jalanko H, Lipsanen-Nyman M 2007 Growth and growth hormone therapy in subjects with mulibrey nanism. Pediatrics 120:e102-e111 (Pubitemid 47036223)
24. American Diabetes Association 2008 Diagnosis and classification of diabetes mellitus. Diabetes Care 31(Suppl 1):S55-S560
25. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ 2001 A modelbased method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24:539-548 (Pubitemid 32198427)
26. Lippe BM, Kaplan SA, Golden MP, Hendricks SA, Scott ML 1981 Carbohydrate tolerance and insulin receptor binding in children with hypopituitarism: response after acute and chronic human growth hormone administration. J Clin Endocrinol Metab 53:507-513 (Pubitemid 12005790)
27. Kanety H, Hemi R, Ginsberg S, Pariente C, Yissachar E, Barhod E, Funahashi T, Laron Z 2009 Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity. Eur J Endocrinol 161:837-844
28. Oliveira CR, Salvatori R, Nóbrega LM, Carvalho EO, Menezes M, Farias CT, Britto AV, Pereira RM, Aguiar-Oliveira MH 2008 Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene. Clin Endocrinol (Oxf) 69:153-158 (Pubitemid 351863589)
29. Paolisso G, Ammendola S, Del Buono A, Gambardella A, Riondino M, Tagliamonte MR, Rizzo MR, Carella C, Varricchio M 1997 Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function. J Clin Endocrinol Metab 82:2204-2209 (Pubitemid 27287585)
30. Yu R, Yakar S, Liu YL, Lu Y, LeRoith D, Miao D, Liu JL 2003 Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance. Mol Cell Endocrinol 204:31-42 (Pubitemid 36871550)
31. Bengtsson BA 1998 Untreated growth hormone deficiency explains premature mortality in patients with hypopituitarism. Growth Horm IGF Res 8(Suppl A):77-80
32. Bülow B, Hagmar L, Eskilsson J, Erfurth EM 2000 Hypopituitary females have a high incidence of cardiovascular morbidity and an increased prevalence of cardiovascular risk factors. J Clin Endocrinol Metab 85:574-584 (Pubitemid 32279601)
33. Brunzell JD, Robertson RP, Lerner RL, Hazzard WR, Ensinck JW, Bierman EL, Porte Jr D 1976 Relationships between fasting plasma glucose levels and insulin secretion using intravenous glucose tolerance tests. J Clin Endocrinol Metab 42:222-229
34. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD 2011 Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 3:70ra13