Postprandial triglyceride profile after a standardized oral fat load is altered in growth hormone (GH)-deficient adult patients and is not improved after short-term GH replacement therapy

Clinical Endocrinology

Volumn 77, Issue 5, 2012, Pages 721-727

  Perotti, Mario ^a   Caumo, Andrea ^b   Brunani, Amelia ^c   Cambiaghi, Nadia ^a   Casati, Marco ^a   Scacchi, Massimo ^c,d   Perra, Silvia ^a   Rocco, Cristina ^a   Mancia, Giuseppe ^a   Grassi, Guido ^e   Cavagnini, Francesco ^c   Pincelli, Angela Ida ^a  

^a SAN GERARDO HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e IRCCS MULTIMEDICA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH HORMONE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FAT TOLERANCE TEST; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE REPLACEMENT THERAPY; HORMONE SUBSTITUTION; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; BODY COMPOSITION; FEMALE; GLUCOSE TOLERANCE TEST; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; INSULIN; INSULIN RESISTANCE; MALE; POSTPRANDIAL PERIOD; TRIGLYCERIDES;

EID: 84867245284     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2012.04416.x     Document Type: Article

References (33)

1. DeBoer, H., Blok, G.J., &, van der Veen, E.A., (1995) Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews, 16, 63-86.
2. Gola, M., Bonadonna, S., Doga, M., et al,. (2005) Clinical review: growth hormone and cardiovascular risk factors. Journal of Clinical Endocrinology and Metabolism, 90, 1864-1870. (Pubitemid 40464062)
3. Verhelst, J., &, Abs, R., (2009) Cardiovascular risk factors in hypopituitary GH-deficient adults. European Journal of Endocrinology, 161 (Suppl. 1), S41-S49.
4. Murray, R.D., Wieringa, G.E., Lissett, C.A., et al,. (2002) GH replacement improves the adverse lipid profile associated with the adult GH deficiency syndrome. Clinical Endocrinology, 56, 525-532. (Pubitemid 34429628)
5. Monson, J.P., Jönsson, P., Koltowska-Häggström, M., et al,. (2007) Growth hormone replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy. Clinical Endocrinology, 67, 623-628. (Pubitemid 47421960)
6. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (2002) Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III) final report. Circulation, 106, 3143-3421.
7. Stensvold, I., Tverdal, A., Urdal, P., et al,. (1993) Non-fasting serum triglyceride concentration and mortality from coronary heart disease and any cause in middle aged Norwegian women. British Medical Journal, 307, 1318-1322. (Pubitemid 23337748)
8. Stalenhoef, A.F., &, de Graaf, J., (2008) Association of fasting and nonfasting serum triglycerides with cardiovascular disease and the role of remnant-like lipoproteins and small dense LDL. Current Opinion in Lipidology, 19, 355-361.
9. Nordestgaard, B.G., Benn, M., Schnohr, P., et al,. (2007) Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA, 298, 299-308. (Pubitemid 47080484)
10. Jørgensen, A.P., Fougner, K.J., Ueland, T., et al,. (2011) Favorable long-term effects of growth hormone replacement therapy on quality of life, bone metabolism, body composition and lipid levels in patients with adult-onset growth hormone deficiency. Growth Hormone & IGF Research, 21, 69-75.
11. Abrams, P., Boquete, H., Fideleff, H., et al,. (2008) GH replacement in hypopituitarism improves lipid profile and quality of life independently of changes in obesity variables. European Journal of Endocrinology, 159, 825-832.
12. Cuneo, R.C., Salomon, F., Watts, G.F., et al,. (1993) Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism Clinical and Experimental, 42, 1519-1523. (Pubitemid 24001166)
13. Al- Shoumer, K.A., Cox, K.H., Hughes, C.L., et al,. (1997) Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy. Journal of Clinical Endocrinology and Metabolism, 82, 2653-2659. (Pubitemid 27337888)
14. Trepp, R., Stettler, C., Diem, P., et al,. (2010) Effect of growth hormone (GH) on fasting and postprandial metabolism in GH deficiency. Experimental and Clinical Endocrinology & Diabetes, 118, 596-601.
15. Corneli, G., Di Somma, C., Baldelli, R., et al,. (2005) The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. European Journal of Endocrinology, 153, 257-264. (Pubitemid 41174451)
16. Friedewald, W.T., Levy, R.I., &, Fredrickson, D.S., (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18, 499-502.
17. Bergman, R.N., (1989) Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes, 38, 1512-1527. (Pubitemid 20006675)
18. Kolovou, G.D., Mikhailidis, D.P., Kovar, J., et al,. (2011) Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Current Vascular Pharmacology, 9, 258-270.
19. DeFronzo, R.A., Tobin, J., &, Andres, R., (1979) Glucose clamp technique: a method for quantifying insulin secretion and insulin resistance. American Journal of Physiology, 237, 214-223.
20. Pritchard, J.E., Nowson, C.A., Strauss, B.J., et al,. (1993) Evaluation of dual energy X-ray absorptiometry as a method of measurement of body fat. European Journal of Clinical Nutrition, 47, 216-228. (Pubitemid 23099691)
21. Tokunaga, K., Matsuzawa, Y., Ishikawa, K., et al,. (1983) A novel technique for the determination of body fat by computed tomography. International Journal of Obesity, 7, 437-445. (Pubitemid 13020976)
22. Sjöström, L., (1991) A computer-tomography based multicompartment body composition technique and anthropometric predictions of lean body mass, total and subcutaneous adipose tissue. International Journal of Obesity, 15 (Suppl. 2), 19-30.
23. Sjöström, L., Kvist, H., Cederblad, A., et al,. (1986) Determination of total adipose tissue and body fat in women by computed tomography, 40K, and tritium. American Journal of Physiology, 250, 736-745.
24. Nordestgaard, B.G., &, Freiberg, J.J., (2011) Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol. Current Vascular Pharmacology, 9, 281-286.
25. Twickler, T.B., Wilmink, H.W., Schreuder, P.C., et al,. (2000) Growth hormone (GH) treatment decreases postprandial remnant-like particle cholesterol concentration and improves endothelial function in adult-onset GH deficiency. Journal of Clinical Endocrinology and Metabolism, 85, 4683-4689. (Pubitemid 32157652)
26. Nakajima, K., Nakano, T., Moon, H.D., et al,. (2009) The correlation between TG vs remnant lipoproteins in the fasting and postprandial plasma of 23 volunteers. Clinica Chimica Acta, 404, 124-127.
27. Sadur, C.N., Yost, T.J., &, Eckel, R.H., (1984) Insulin responsiveness of adipose tissue lipoprotein lipase is delayed but preserved in obesity. Journal of Clinical Endocrinology and Metabolism, 59, 1176-1182. (Pubitemid 15223356)
28. Mitrou, P., Boutati, E., Lambadiari, V., et al,. (2010) Rates of lipid fluxes in adipose tissue in vivo after a mixed meal in morbid obesity. International Journal of Obesity, 34, 770-774.
29. Nabeno-Kaeriyama, Y., Fukuchi, Y., Hayashi, S., et al,. (2010) Delayed postprandial metabolism of triglyceride-rich lipoproteins in obese young men compared to lean young men. Clinica Chimica Acta, 411, 1694-1699.
30. Couillard, C., Bergeron, N., Prud'homme, D., et al,. (1998) Postprandial triglyceride response in visceral obesity in men. Diabetes, 47, 953-960. (Pubitemid 28255671)
31. O' Neal, D.N., Kalfas, A., Dunning, P.L., et al,. (1994) The effect of 3 months of recombinant human growth hormone (GH) therapy on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults: a minimal model analysis. Journal of Clinical Endocrinology and Metabolism, 79, 975-983.
32. O' Neal, D.N., Hew, F.L., Best, J.D., et al,. (1999) The effect of 24 months recombinant human growth hormone (rh-GH) on LDL cholesterol, triglyceride-rich lipoproteins and apo [a] in hypopituitary adults previously treated with conventional replacement therapy. Growth Hormone IGF & Research, 9, 165-173. (Pubitemid 29468748)
33. Giavoli, C., Porretti, S., Ronchi, C.L., et al,. (2004) Long-term monitoring of insulin sensitivity in growth hormone-deficient adults on substitutive recombinant human growth hormone therapy. Metabolism, 53, 740-743. (Pubitemid 38880904)