Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin

Laboratory Investigation

Volumn 94, Issue 3, 2014, Pages 262-274

  Pisonero Vaquero, Sandra ^a   García Mediavilla, María V ^a,b   Jorquera, Francisco ^b,c   Majano, Pedro L ^b,d   Benet, Marta ^b,e   Jover, Ramiro ^b,e,f   González Gallego, Javier ^a,b   Sánchez Campos, Sonia ^a,b  

^a UNIVERSITY OF LEÓN   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c Gerencia Regional de Salud de Castilla y León   (Spain)

^d Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa   (Spain)

^e INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^f UNIVERSITY OF VALENCIA   (Spain)

Author keywords

HCV replication; lipogenesis; LXRa; oxidative stress; PI3K AKT pathway; quercetin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA INTERFERON; APIGENIN; KAEMPFEROL; LIVER X RECEPTOR ALPHA; NITROGEN DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; QUERCETIN; REACTIVE OXYGEN METABOLITE; TAXIFOLIN; TRIACYLGLYCEROL;

ADENOVIRUS INFECTION; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; GENE OVEREXPRESSION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; LIPID STORAGE; LIPOGENESIS; NITROSATIVE STRESS; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; REPLICON; UPREGULATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIOXIDANTS; ANTIVIRAL AGENTS; APIGENIN; CELL LINE; CHROMONES; DOWN-REGULATION; FATTY ACIDS, NONESTERIFIED; HEPACIVIRUS; HUMANS; KAEMPFEROLS; LIPOGENESIS; MORPHOLINES; ORPHAN NUCLEAR RECEPTORS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN; REACTIVE NITROGEN SPECIES; SIGNAL TRANSDUCTION; TRIGLYCERIDES; VIRUS REPLICATION;

EID: 84896896377     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.156     Document Type: Article

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