-
1
-
-
0036105482
-
The interferon antiviral response: From viral invasion to evasion
-
Grandvaux N, tenOever BR, Servant MJ, Hiscott J. The interferon antiviral response: from viral invasion to evasion. Curr. Opin. Infect. Dis., 15, 259-267 (2002).
-
(2002)
Curr. Opin. Infect. Dis.
, vol.15
, pp. 259-267
-
-
Grandvaux, N.1
TenOever, B.R.2
Servant, M.J.3
Hiscott, J.4
-
2
-
-
18844457095
-
Mechanisms of type-I- And type-II-interferon-mediated signalling
-
Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat. Rev. Immunol., 5, 375-386 (2005).
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 375-386
-
-
Platanias, L.C.1
-
3
-
-
0029069145
-
Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
-
Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem., 64, 621-651 (1995).
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 621-651
-
-
Schindler, C.1
Darnell Jr., J.E.2
-
4
-
-
0242468041
-
Regulation of JAK-STAT signalling in the immune system
-
Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol., 3, 900-911 (2003).
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 900-911
-
-
Shuai, K.1
Liu, B.2
-
5
-
-
1042302005
-
The STATs of cancer-new molecular targets come of age
-
Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat. Rev. Cancer, 4, 97-105 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
6
-
-
5644242144
-
Is JAK3 a new drug target for immunomodulation-based therapies?
-
Papageorgiou AC, Wikman LEK. Is JAK3 a new drug target for immunomodulation-based therapies? Trends Pharmacol. Sci., 25, 558-562 (2004).
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 558-562
-
-
Papageorgiou, A.C.1
Wikman, L.E.K.2
-
7
-
-
33747095403
-
Antiviral drug resistance
-
Richman DD. Antiviral drug resistance. Antiviral Res., 71, 117-121 (2006).
-
(2006)
Antiviral Res.
, vol.71
, pp. 117-121
-
-
Richman, D.D.1
-
8
-
-
0035134688
-
Interferon in oncological practice: Review of interferon biology, clinical applications, and toxicities
-
Jonasch E, Haluska FG. Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities. Oncologist, 6, 34-55 (2001).
-
(2001)
Oncologist
, vol.6
, pp. 34-55
-
-
Jonasch, E.1
Haluska, F.G.2
-
9
-
-
0032504007
-
A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor
-
see comments
-
Tian SS, Lamb P, King AG, Miller SG, Kessler L, Luengo JI, Averill L, Johnson RK, Gleason JG, Pelus LM, Dillon SB, Rosen J. A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor [see comments]. Science, 281, 257-259 (1998).
-
(1998)
Science
, vol.281
, pp. 257-259
-
-
Tian, S.S.1
Lamb, P.2
King, A.G.3
Miller, S.G.4
Kessler, L.5
Luengo, J.I.6
Averill, L.7
Johnson, R.K.8
Gleason, J.G.9
Pelus, L.M.10
Dillon, S.B.11
Rosen, J.12
-
10
-
-
0033532347
-
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
-
Zhang B, Salituro G, Szalkowski D, Li ZH, Zhang Y, Royo I, Vilella D, Díez MT, Pelaez F, Ruby C, Kendall RL, Mao XZ, Griffin P, Calaycay J, Zierath JR, Heck JV, Smith RG, Moller DE. Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science, 284, 974-977 (1999).
-
(1999)
Science
, vol.284
, pp. 974-977
-
-
Zhang, B.1
Salituro, G.2
Szalkowski, D.3
Li, Z.H.4
Zhang, Y.5
Royo, I.6
Vilella, D.7
Díez, M.T.8
Pelaez, F.9
Ruby, C.10
Kendall, R.L.11
Mao, X.Z.12
Griffin, P.13
Calaycay, J.14
Zierath, J.R.15
Heck, J.V.16
Smith, R.G.17
Moller, D.E.18
-
11
-
-
0037964430
-
A peptide mimetic of human interferon (IFN)-beta
-
Sato A, Sone S. A peptide mimetic of human interferon (IFN)-beta. Biochem. J., 371, 603-608 (2003).
-
(2003)
Biochem. J.
, vol.371
, pp. 603-608
-
-
Sato, A.1
Sone, S.2
-
12
-
-
33847073462
-
A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFNgamma in human cancer cells
-
Lynch RA, Etchin J, Battle TE, Frank DA. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFNgamma in human cancer cells. Cancer Res., 67, 1254-1261 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 1254-1261
-
-
Lynch, R.A.1
Etchin, J.2
Battle, T.E.3
Frank, D.A.4
-
13
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov., 4, 206-220 (2005).
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
14
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang JH, Chung TDY, Oldenburg KR. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen., 4, 67-73 (1999).
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.Y.2
Oldenburg, K.R.3
-
15
-
-
0034658111
-
Pharmaceutical intervention in the JAK/STAT signaling pathway
-
Seidel HM, Lamb P, Rosen J. Pharmaceutical intervention in the JAK/STAT signaling pathway. Oncogene, 19, 2645-2656 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2645-2656
-
-
Seidel, H.M.1
Lamb, P.2
Rosen, J.3
-
16
-
-
33748522384
-
Inhibition of the replication of hepatitis B virus in vitro by emodin
-
Shuangsuo D, Zhengguo Z, Yunru C, Xin Z, Baofeng W, Lichao Y, Yan'an C. Inhibition of the replication of hepatitis B virus in vitro by emodin. Med. Sci. Monit., 12, BR302-BR306 (2006).
-
(2006)
Med. Sci. Monit.
, vol.12
-
-
Shuangsuo, D.1
Zhengguo, Z.2
Yunru, C.3
Xin, Z.4
Baofeng, W.5
Lichao, Y.6
Yan'An, C.7
-
17
-
-
50549094449
-
Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
-
Lin CW, Wu CF, Hsiao NW, Chang CY, Li SW, Wan L, Lin YJ, Lin WY. Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71. Int. J. Antimicrob. Agents, 32, 355-359 (2008).
-
(2008)
Int. J. Antimicrob. Agents
, vol.32
, pp. 355-359
-
-
Lin, C.W.1
Wu, C.F.2
Hsiao, N.W.3
Chang, C.Y.4
Li, S.W.5
Wan, L.6
Lin, Y.J.7
Lin, W.Y.8
-
18
-
-
0346887168
-
Antiproliferative activity of various flavonoids and related compounds: Additive effect of interferon-α2b
-
Blank VC, Poli C, Marder M, Roguin LP. Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-α2b. Bioorg. Med. Chem. Lett., 14, 133-136 (2004).
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 133-136
-
-
Blank, V.C.1
Poli, C.2
Marder, M.3
Roguin, L.P.4
-
19
-
-
56049123402
-
The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
-
Aalinkeel R, Bindukumar B, Reynolds JL, Sykes DE, Mahajan SD, Chadha KC, Schwartz SA. The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. Prostate, 68, 1773-1789 (2008).
-
(2008)
Prostate
, vol.68
, pp. 1773-1789
-
-
Aalinkeel, R.1
Bindukumar, B.2
Reynolds, J.L.3
Sykes, D.E.4
Mahajan, S.D.5
Chadha, K.C.6
Schwartz, S.A.7
-
20
-
-
79955044159
-
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling
-
Proia DA, Foley KP, Korbut T, Sang J, Smith D, Bates RC, Liu YA, Rosenberg AF, Zhou D, Koya K, Barsoum J, Blackman RK. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS ONE, 6, e18552 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Proia, D.A.1
Foley, K.P.2
Korbut, T.3
Sang, J.4
Smith, D.5
Bates, R.C.6
Liu, Y.A.7
Rosenberg, A.F.8
Zhou, D.9
Koya, K.10
Barsoum, J.11
Blackman, R.K.12
-
21
-
-
47249126290
-
Anti-influenza virus activities of flavonoids from the medicinal plant Elsholtzia rugulosa
-
Liu AL, Liu B, Qin HL, Lee SMY, Wang YT, Du GH. Anti-influenza virus activities of flavonoids from the medicinal plant Elsholtzia rugulosa. Planta Med., 74, 847-851 (2008).
-
(2008)
Planta Med.
, vol.74
, pp. 847-851
-
-
Liu, A.L.1
Liu, B.2
Qin, H.L.3
Lee, S.M.Y.4
Wang, Y.T.5
Du, G.H.6
-
22
-
-
70449729630
-
Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: Additive effects of IFN-β
-
Sternberg Z, Chadha K, Lieberman A, Drake A, Hojnacki D, Weinstock- Guttman B, Munschauer F. Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-β. J. Neuroinflammation, 6, 28 (2009).
-
(2009)
J. Neuroinflammation
, vol.6
, pp. 28
-
-
Sternberg, Z.1
Chadha, K.2
Lieberman, A.3
Drake, A.4
Hojnacki, D.5
Weinstock- Guttman, B.6
Munschauer, F.7
-
23
-
-
24744449776
-
Protein kinase C inhibition and X-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells
-
Shi RX, Ong CN, Shen HM. Protein kinase C inhibition and X-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Cancer Res., 65, 7815-7823 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 7815-7823
-
-
Shi, R.X.1
Ong, C.N.2
Shen, H.M.3
-
24
-
-
22544474648
-
Inhibition of IFN-alpha signaling by a PKC- And protein tyrosine phosphatase SHP-2-dependent pathway
-
Du ZM, Shen YH, Yang WT, Mecklenbrauker I, Neel BG, Ivashkiv LB. Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway. Proc. Natl. Acad. Sci. U.S.A., 102, 10267-10272 (2005).
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 10267-10272
-
-
Du, Z.M.1
Shen, Y.H.2
Yang, W.T.3
Mecklenbrauker, I.4
Neel, B.G.5
Ivashkiv, L.B.6
-
25
-
-
0242663859
-
Differential responses to IFN-alpha subtypes in human T cells and dendritic cells
-
Hilkens CMU, Schlaak JF, Kerr IM. Differential responses to IFN-alpha subtypes in human T cells and dendritic cells. J. Immunol., 171, 5255-5263 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 5255-5263
-
-
Hilkens, C.M.U.1
Schlaak, J.F.2
Kerr, I.M.3
-
26
-
-
33748450379
-
Complex modulation of cell type-specific signaling in response to type I interferons
-
van Boxel-Dezaire AHH, Rani MRS, Stark GR. Complex modulation of cell type-specific signaling in response to type I interferons. Immunity, 25, 361-372 (2006).
-
(2006)
Immunity
, vol.25
, pp. 361-372
-
-
Van Boxel-Dezaire, A.H.H.1
Rani, M.R.S.2
Stark, G.R.3
-
27
-
-
0035344461
-
A weak signal for strong responses: Interferon- Alpha/beta revisited
-
Taniguchi T, Takaoka A. A weak signal for strong responses: interferon- alpha/beta revisited. Nat. Rev. Mol. Cell Biol., 2, 378-386 (2001).
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 378-386
-
-
Taniguchi, T.1
Takaoka, A.2
|