Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells

Oncotarget

Volumn 5, Issue 3, 2014, Pages 841-852

  Zhang, Jingjie ^a   Gao, Guangxun ^a,b   Chen, Liang ^a   Li, Jingxia ^a   Deng, Xu ^c   Zhao, Qin Shi ^c   Huang, Chuanshu ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

Apoptosis; Cheliensisin A; chemotherapeutic agent; colon cancer; p53

Indexed keywords

ANTINEOPLASTIC AGENT; ATR PROTEIN; CASPASE 3; CHECKPOINT KINASE 2; CHELIENSISIN A; HYDROGEN PEROXIDE; LACTONE DERIVATIVE; PROTEIN P53; UNCLASSIFIED DRUG; ATM PROTEIN; ATR PROTEIN, HUMAN; CHEK2 PROTEIN, HUMAN; EPOXIDE; PYRONE DERIVATIVE; TP53 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL STRAIN HCT116; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; COLONIC NEOPLASMS; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HCT116 CELL LINE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CHECKPOINT KINASE 2; COLONIC NEOPLASMS; EPOXY COMPOUNDS; HCT116 CELLS; HUMANS; HYDROGEN PEROXIDE; PYRONES; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84896836717     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1780     Document Type: Article

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