Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 3, 2014, Pages 733-743

  Forneris, Federico ^a   Burnley, B Tom ^a,b   Gros, Piet ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b SCIENCE AND TECHNOLOGY FACILITIES COUNCIL   (United Kingdom)

Author keywords

Complement system; Ensemble refinement; Proteolysis; Structural dynamics

Indexed keywords

COMPLEMENT FACTOR D; COMPLEMENT FACTOR D, HUMAN; THROMBIN;

ARTICLE; CHEMISTRY; COMPLEMENT SYSTEM; DRUG ANTAGONISM; ENSEMBLE REFINEMENT; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; HEK293 CELL LINE; HUMAN; MOLECULAR DYNAMICS; MUTATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; STRUCTURAL DYNAMICS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

COMPLEMENT SYSTEM; ENSEMBLE REFINEMENT; PROTEOLYSIS; STRUCTURAL DYNAMICS;

CATALYTIC DOMAIN; COMPLEMENT FACTOR D; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN CONFORMATION; PROTEOLYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 84896753255     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004713032549     Document Type: Article

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