MDMA induces cardiac contractile dysfunction through autophagy upregulation and lysosome destabilization in rats

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 5, 2014, Pages 691-700

  Shintani Ishida, Kaori ^a   Saka, Kanju ^a   Yamaguchi, Koji ^b   Hayashida, Makiko ^b   Nagai, Hisashi ^a   Takemura, Genzou ^c   Yoshida, Ken ichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Autophagy; Cardiac contractile dysfunction; Cathepsin; Lysosome; MDMA

Indexed keywords

3 METHYLADENINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ADENOSINE PHOSPHATE; ADENYLATE KINASE; ALOXISTATIN ACID; CATHEPSIN; CHLOROQUINE; LIGHT CHAIN 3 II; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CARDIAC CONTRACTILE DYSFUNCTION; CARDIOTOXICITY; CELL VACUOLE; CONTROLLED STUDY; CYTOSOL; DEGRADATION; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; HEART DISEASE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; LIGHT CHAIN; LYSOSOME; MALE; NONHUMAN; PHOSPHORYLATION; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAPTOR; RAT; UPREGULATION; WESTERN BLOTTING;

AUTOPHAGY; CARDIAC CONTRACTILE DYSFUNCTION; CATHEPSIN; LYSOSOME; MDMA;

ADENYLATE KINASE; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CHROMATOGRAPHY, LIQUID; LYSOSOMES; MALE; MICROSCOPY, ELECTRON; MYOCARDIAL CONTRACTION; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84896740275     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.01.013     Document Type: Article

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