Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes

Cardiovascular Toxicology

Volumn 9, Issue 1, 2009, Pages 30-38

  Shenouda, Sylvia K ^a   Varner, Kurt J ^a   Carvalho, Felix ^b   Lucchesi, Pamela A ^c  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Calcium; Ecstasy; IonOptix; Rat

Indexed keywords

2,5 BIS(GLUTATHION S YL) ALPHA METHYLDOPAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ACETYLCYSTEINE; ALPHA METHYLDOPAMINE; CALCIUM; DRUG METABOLITE; HYDROETHIDINE; N METHYL ALPHA METHYLDOPAMINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 2,5 BIS(GLUTATHIONYL)METHYLDOPAMINE; 2,5-BIS(GLUTATHIONYL)METHYLDOPAMINE; ALPHA-METHYLDOPAMINE; ANTIOXIDANT; DRUG DERIVATIVE; EPININE; GLUTATHIONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL FUNCTION; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VELOCITY; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; HEART CONTRACTION; HEART VENTRICLE; METABOLISM; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

MEDA; RATTUS;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CALCIUM SIGNALING; CELLS, CULTURED; DEOXYEPINEPHRINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HEART VENTRICLES; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 66849131206     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-009-9034-6     Document Type: Article

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