Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation

Cardiovascular Research

Volumn 94, Issue 3, 2012, Pages 480-491

  Guo, Rui ^a   Ren, Jun ^a  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

AMPK deficiency; Autophagy; Cardiac function; Ethanol; ULK1

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; ADENYLATE KINASE ALPHA; ALCOHOL; BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN LC3I; PROTEIN LC3II; PROTEIN LC3III; PROTEIN P62; PROTEIN RAPTOR; SERINE; UNC51 LIKE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; DOWN REGULATION; ECHOCARDIOGRAPHY; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE MUTATION; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HEART DISEASE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART PERFUSION; ISOLATED HEART; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE;

ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; DOWN-REGULATION; ETHANOL; GLUCOSE; HEART; MICE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; SIGNAL TRANSDUCTION;

EID: 84861398110     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs127     Document Type: Article

References (43)

1. O'Keefe JH, Bybee KA, Lavie CJ. Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol 2007;50:1009-1014. (Pubitemid 47348233)
2. Stolle M, Sack PM, Thomasius R. Binge drinking in childhood and adolescence: epidemiology, consequences, and interventions. Dtsch Arztebl Int 2009;106:323-328.
3. Patel VB, Why HJ, Richardson PJ, Preedy VR. The effects of alcohol on the heart. Adverse Drug React Toxicol Rev 1997;16:15-43. (Pubitemid 27230650)
4. Ren J,Wold LE. Mechanisms of alcoholic heart disease. Ther Adv Cardiovasc Dis 2008;2: 497-506.
5. Guo R, Ren J. Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway. PLoS One 2010;5:e8757.
6. Hannuksela ML, Liisanantti MK, Savolainen MJ. Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis. Crit Rev Clin Lab Sci 2002;39:225-283. (Pubitemid 34753845)
7. Guo R, Scott GI, Ren J. Involvement of AMPK in alcohol dehydrogenase accentuated myocardial dysfunction following acute ethanol challenge in mice. PLoS One 2010;5: e11268.
8. Beauloye C, Bertrand L, Horman S, Hue L. AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc Res 2011;90: 224-233.
9. Kim M, Tian R. Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol 2011;51:548-553.
10. Kolwicz SC Jr, Tian R. Glucose metabolism and cardiac hypertrophy. Cardiovasc Res 2011;90:194-201.
11. Paiva MA, Rutter-Locher Z, Goncalves LM, Providencia LA, Davidson SM, Yellon DM et al. Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury. Am J Physiol Heart Circ Physiol 2011;300:H2123-2134.
12. Nemchenko A, Chiong M, Turer A, Lavandero S, Hill JA. Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol 2011;51:584-593.
13. Xie M, Morales CR, Lavandero S, Hill JA. Tuning flux: autophagy as a target of heart disease therapy. Curr Opin Cardiol 2011;26:216-222.
14. Ding WX, Manley S, Ni HM. The emerging role of autophagy in alcoholic liver disease. Exp Biol Med (Maywood) 2011;236:546-556.
15. Osna NA, Thomes PG, Donohue TM Jr. Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis. World J Gastroenterol 2011;17:2507-2514.
16. Ge W, Guo R, Ren J. AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol. Free Radic Biol Med 2011;51:1736-1748.
17. Ge W, Ren J. mTOR-STAT3-notch signaling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. J Cell Mol Med 2011;16:615-625.
18. Hoyer-Hansen M, Jaattela M. AMP-activated protein kinase: a universal regulator of autophagy? Autophagy 2007;3:381-383. (Pubitemid 46986350)
19. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 30:214-226. (Pubitemid 351626684)
20. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-590. (Pubitemid 37506046)
21. Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011;331:456-461.
22. Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011;13:132-141.
23. Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009;284: 12297-12305.
24. Duan J, McFadden GE, Borgerding AJ, Norby FL, Ren BH, Ye G et al. Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes. Am J Physiol Heart Circ Physiol 2002;282:H1216-1222. (Pubitemid 34654871)
25. Li SY, Ren J. Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. J Mol Cell Cardiol 2008;44:992-1001.
26. Manning WJ, Wei JY, Katz SE, Litwin SE, Douglas PS. In vivo assessment of LV mass in mice using high-frequency cardiac ultrasound: necropsy validation. Am J Physiol 1994; 266:H1672-1675. (Pubitemid 24150800)
27. Gardin JM, Siri FM, Kitsis RN, Edwards JG, Leinwand LA. Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ Res 1995;76:907-914.
28. Ryu JH, Cho YS, Chun YS, Park JW. Myocardial SSAT induction via AMPK signaling and its implication for ischemic injury. Biochem Biophys Res Commun 2008;366: 438-444.
29. Ceylan-Isik AF, Zhao P, Zhang B, Xiao X, Su G, Ren J. Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol 2010;48:367-378.
30. Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem 2007;282:18573-18583. (Pubitemid 47100226)
31. Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC et al. LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol 2009;296:H470-479.
32. Edick MJ, Tesfay L, Lamb LE, Knudsen BS, Miranti CK. Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death. Mol Biol Cell 2007;18:2481-2490. (Pubitemid 47025714)
33. Turdi S, Kandadi MR, Zhao J, Huff AF, Du M, Ren J. Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Cardiol 2011;50:712-722.
34. Spies CD, Sander M, Stangl K, Fernandez-Sola J, Preedy VR, Rubin E et al. Effects of alcohol on the heart. Curr Opin Crit Care 2001;7:337-343. (Pubitemid 33064363)
35. Donovan JE. Estimated blood alcohol concentrations for child and adolescent drinking and their implications for screening instruments. Pediatrics 2009;123:e975-981.
36. Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF et al. Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase. J Biol Chem 2003;278:28372-28377. (Pubitemid 36935737)
37. Musi N, Hirshman MF, Arad M, Xing Y, Fujii N, Pomerleau J et al. Functional role of AMP-activated protein kinase in the heart during exercise. FEBS Lett 2005;579: 2045-2050. (Pubitemid 40469668)
38. Cowherd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH et al. Adiponectin lowers glucose production by increasing SOGA. Am J Pathol 2010;177: 1936-1945.
39. Gottlieb RA, Mentzer RM. Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol 2010;72:45-59.
40. Hardie DG. AMPK and autophagy get connected. EMBO J 2011;30:634-635.
41. Bergheim I, Guo L, Davis MA, Lambert JC, Beier JI, Duveau I et al. Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1. Gastroenterology 2006;130:2099-2112. (Pubitemid 43816952)
42. Bach M, Larance M, James DE, Ramm G. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem J 2011;440:283-291.
43. Chan EY, Longatti A, McKnight NC, Tooze SA. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol 2009;29:157-171.