Competition for Antigen between Th1 and Th2 Responses Determines the Timing of the Immune Response Switch during Mycobaterium avium Subspecies paratuberulosis Infection in Ruminants

PLoS Computational Biology

Volumn 10, Issue 1, 2014, Pages

  Magombedze, Gesham ^a   Eda, Shigetoshi ^a   Ganusov, Vitaly V ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BACTERIA; IMMUNE SYSTEM; MACROPHAGES; MAMMALS; T-CELLS; TIMING CIRCUITS;

ANIMAL RESPONSE; ANTIBODIES RESPONSE; CD4 T-CELLS; CELLULAR RESPONSE; DISEASE PROGRESSION; EXTRACELLULAR; IMMUNE RESPONSE; JOHNE'S DISEASE; PARATUBERCULOSIS; T-CELL RESPONSE;

EFFICIENCY;

GAMMA INTERFERON;

ANTIBODY PRODUCTION; ARTICLE; BACTERIAL KINETICS; BACTERIAL SHEDDING; BOVIDS; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; ENZYME SYNTHESIS; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; MACROPHAGE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MYCOBACTERIUM AVIUM; MYCOBACTERIUM PARATUBERCULOSIS; NONHUMAN; PARATUBERCULOSIS; TH1 TH2 BALANCE;

ALGORITHMS; ANIMALS; COMPUTER SIMULATION; DISEASE PROGRESSION; IMMUNITY, CELLULAR; MACROPHAGES; MODELS, BIOLOGICAL; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; PARATUBERCULOSIS; RUMINANTS; SHEEP; TH1 CELLS; TH2 CELLS;

EID: 84896738474     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003414     Document Type: Article

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