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Volumn 141, Issue , 2014, Pages 121-134

Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents

Author keywords

1,3 Dipolar cycloaddition; Antiproliferative activity; Apoptosis; Cell cycle arrest; Dehydroepiandrosterone; Spiro oxindoles

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; DIMER; FLUOROURACIL; OXINDOLE; PRASTERONE; SPIRO [2'.16] 1' METHYL 2' (5'' BROMO INDOLIN 2 ONE) 4' (4'' CHLOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (5'' FLUORO INDOLIN 2 ONE) 4' (4'' CHLOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (2'' CHLOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (2'' FLUOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (3'' CHLOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (3'' METHOXYLPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (3'' NITROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (3'',4'' DICHLOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' CHLOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' FLUOROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' FURYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' ISOPRENYLPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' METHYLPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' METHYLSULFONYL PHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' NAPHTHYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' NITROPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' PHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' PYRIDYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' TERTBUTHYLPHENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; SPIRO [2'.16] 1' METHYL 2' (INDOLIN 2 ONE) 4' (4'' THIENYL) TETRAHYDRO 1H PYRROLO DEHYDROANDOSTERONE; STEROID; UNCLASSIFIED DRUG;

EID: 84896737743     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.01.015     Document Type: Article
Times cited : (55)

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