Synthesis and biological evaluation of novel steroidal[17,16-d][1,2,4] triazolo[1,5-a]pyrimidines

Steroids

Volumn 77, Issue 6, 2012, Pages 710-715

  Huang, Li Hua ^a   Zheng, Yong Fei ^a   Lu, Yong Zheng ^a   Song, Chuan Jun ^a   Wang, Yan Guang ^a   Yu, Bin ^a   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

1,2,4 Triazolo 1,5 a pyrimidines; Anticancer activity; Heterosteroids; Steroidal 17,16 d triazolopyrimidines

Indexed keywords

16 ARYLIDENE 17 KETOSTEROID DERIVATIVE; 3 OXO 4 AZA 7' (2 PYRIDYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (2 THIENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (3 NITROPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (3 PHENOXYPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (3,4,5 TRIMETHOXYPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 BROMOPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 CHLOROPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 DIMETHYLAMINOPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 FLUOROPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 ISOPROPYLPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 METHOXYPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 METHYLSULFONYLPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (4 MORPHOLINYLPHENYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' (5 METHYLFURYL) 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3 OXO 4 AZA 7' PHENYL 5ALPHA ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (2 PYRIDYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (3 PHENOXYPHENYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (4 CHLOROPHENYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (4 DIMETHYLAMINOPHENYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (4 ISOPROPYLPHENYLPHENYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (4 METHOXYPHENYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (4 METHYLSULFONYLPHENYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' (4 MORPHOLINYLPHENYL)ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 3BETA HYDROXY 5 EN 7' PHENYL ANDROSTANO[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; AMITROLE; ANTINEOPLASTIC AGENT; PYRIMIDINE DERIVATIVE; STEROID; STEROIDAL[17,16 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; POLYMERIZATION; X RAY ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; INHIBITORY CONCENTRATION 50; STEROIDS; TRIAZOLES;

EID: 84859848338     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.03.002     Document Type: Article

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