A novel [1,2,4] triazolo [1,5-a] pyrimidine-based phenyl-linked steroid dimer: Synthesis and its cytotoxic activity

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 323-330

  Yu, Bin ^a   Shi, Xiao Jing ^a   Zheng, Yong Fei ^a   Fang, Yuan ^a   Zhang, En ^a   Yu, De Quan ^b   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

1,2,4 Triazolo 1,5 a pyrimidine; Apoptosis; Cell cycle arrest; Cytotoxicity; Mitochondrial pathway; Steroid dimmer

Indexed keywords

[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; DIMER; PROTEIN BAX; PROTEIN MDM2; PROTEIN P53; PYRIMIDINE DERIVATIVE; STEROID; UNCLASSIFIED DRUG;

APOPTOSIS; AROMATIZATION; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; MICHAEL ADDITION; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYMERIZATION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UPREGULATION;

APOPTOSIS; CELL CYCLE ARREST; CYTOTOXICITY; MITOCHONDRIAL PATHWAY; STEROID DIMER; [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DIMERIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; PYRIMIDINES; STEROIDS; TRIAZOLES;

EID: 84884373879     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.029     Document Type: Article

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