Efficient construction of novel D-ring modified steroidal dienamides and their cytotoxic activities

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 171-179

  Yu, Bin ^a   Shi, Xiao Jing ^a   Ren, Jing Li ^a   Sun, Xiao Nan ^a   Qi, Ping Ping ^a   Fang, Yuan ^a   Ye, Xian Wei ^a   Wang, Meng Meng ^a   Wang, Jun Wei ^a   Zhang, En ^a   Yu, De Quan ^b   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Apoptosis; Cell cycle arrest; Cytotoxicity; Dehydroepiandrosterone; Dienamides

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; STEROID; 3BETA ACETOXYL 5 EN 16 (2 CHLOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (2 CYANOBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (2 FLUOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (2,4 DICHLOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXO ETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (3 CHLOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE; 3BETA ACETOXYL 5 EN 16 (3 METHOXYLBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (3,4 DICHLOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (3,4 DIFLUOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXO ETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (3,4,5 TRIMETHOXYLBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OOXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (4 BROMOBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (4 CHLOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (4 FLUOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (4 ISOPROPYLBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 (4 METHYLBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 BENZYLIDENE ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 FURYLMETHYLENE ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA ACETOXYL 5 EN 16 THIENYLMETHYLENE ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BETA HYDROXYL 5 EN 16 (2 FLUOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXO ETHYLIDENE); 3BETA HYDROXYL 5 EN 16 (3 METHOXYLBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXO ETHYLIDENE); 3BETA HYDROXYL 5 EN 16 (3,4 DICHLOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXO ETHYLIDENE); 3BETA HYDROXYL 5 EN 16 (3,4,5 TRIMETHOXYL BENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHULIDENE); 3BETA HYDROXYL 5 EN 16 (4 FLUOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXOETHYLIDENE); 3BTEA HYDROXYL 5 EN 16 (2 CHLOROBENZYLIDENE)ANDROSTANO 17 (2 AMINO 1 CYANO 2 OXO ETHYLIDENE); UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESOPHAGUS CANCER; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IN VITRO STUDY; ISOMERIZATION; LIVER CANCER; NUCLEOPHILICITY; POLYMERIZATION; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; STOMACH CANCER; CANCER CELL LINE; CHEMICAL BOND; CYTOTOXICITY; G2 PHASE CELL CYCLE CHECKPOINT; IC50;

EID: 84879209332     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.035     Document Type: Article

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