Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena

Neuropharmacology

Volumn 79, Issue , 2014, Pages 657-667

  Deng, Meichun ^a,b   Luo, Xuan ^a   Xiao, Yucheng ^a   Sun, Zhenghua ^a   Jiang, Liping ^c   Liu, Zhonghua ^a   Zeng, Xiongzhi ^a   Chen, Hanchun ^b   Tang, Jianhua ^b   Zeng, Weimin ^b   Liang, Songping ^a  

^a HUNAN NORMAL UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c The First People s Hospital of Changde City)   (China)

Author keywords

Analgesic action; Dorsal root ganglia; HWTX XVI; N type calcium channels; Pain model; Rat vas deferens; Tarantula toxin

Indexed keywords

CALCIUM CHANNEL T TYPE; FORMALDEHYDE; HUWENTOXIN XVI; MORPHINE; NEUROTOXIN; POTASSIUM CHANNEL; SODIUM CHANNEL; UNCLASSIFIED DRUG; ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; HUWENTOXIN-XVI, ORNITHOCTONUS HUWENA; SPIDER VENOM;

ADULT; ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; EXPERIMENTAL PAIN; EXPERIMENTAL PAIN TEST; FEMALE; HAPLOPELMA; HOT PLATE TEST; INFLAMMATORY PAIN; LATENT PERIOD; MALE; MOTOR ACTIVITY; MOTOR COORDINATION; MOUSE; MUSCLE TWITCH; NERVE CELL; NONHUMAN; ORNITHOCTONUS HUWENA; PRIORITY JOURNAL; RAT; SPINAL GANGLION; TARANTULA; VAS DEFERENS; VON FREY TEST; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG EFFECTS; HYPERALGESIA; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PAIN; PHYSIOLOGY; SPIDER; SPRAGUE DAWLEY RAT; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; BASE SEQUENCE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CALCIUM CHANNELS, T-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GANGLIA, SPINAL; HYPERALGESIA; MALE; MOLECULAR SEQUENCE DATA; PAIN; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; SPIDER VENOMS; SPIDERS; VAS DEFERENS; XENOPUS LAEVIS;

EID: 84896736211     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.017     Document Type: Article

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