Structure-function relationships of ω-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine- substituted analogues

Journal of Biological Chemistry

Volumn 272, Issue 18, 1997, Pages 12014-12023

  Lew, Michael J ^a   Flinn, James P ^a,b   Pallaghy, Paul K ^b   Murphy, Roger ^a   Whorlow, Sarah L ^a   Wright, Christine E ^a   Norton, Raymond S ^b   Angus, James A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; OMEGA CONOTOXIN GVIA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL MEMBRANE; HEART; HEART ATRIA; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MESENTERIC ARTERIES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; OMEGA-CONOTOXIN GVIA; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN CONFORMATION; RABBITS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPATHETIC NERVOUS SYSTEM; TYROSINE; VAS DEFERENS;

EID: 0030973424     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.18.12014     Document Type: Article

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