PKCε signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Tsirimonaki, Emmanouella ^a   Fedonidis, Constantinos ^a   Pneumaticos, Spiros G ^a,b   Tragas, Adamantios A ^a   Michalopoulos, Ioannis ^a   Mangoura, Dimitra ^a  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; AGGRECAN; AGGRECANASE 2; CELL PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; KI 67 ANTIGEN; MESSENGER RNA; MICRORNA; MICRORNA 377; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN COL2A1; PROTEIN FOS; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C IOTA; PROTEIN KINASE C MU; UNCLASSIFIED DRUG;

ADAMTS5 GENE; ADULT; AGGRECAN GENE; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; GENE PRODUCT; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NUCLEUS PULPOSUS CELL; PHENOTYPE; PKC ALPHA GENE; PKC DELTA GENE; PKC ETA GENE; PKC IOTA GENE; PKC MU GENE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; UPREGULATION;

ADAM PROTEINS; AGGRECANS; BASE SEQUENCE; BLOTTING, WESTERN; CELL DIFFERENTIATION; DNA PRIMERS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INTERVERTEBRAL DISC; MICRORNAS; PROTEIN KINASE C-EPSILON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84896735841     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082045     Document Type: Article

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