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Volumn 58, Issue 2, 2011, Pages 135-144

Cannabinoid receptor 1 induces a biphasic ERK activation via multiprotein signaling complex formation of proximal kinases PKCε, Src, and Fyn in primary neurons

Author keywords

CB1R; ERK; PKC ; Primary neurons; Src

Indexed keywords

CANNABINOID 1 RECEPTOR; CATENIN; MARCKS PROTEIN; METHANANDAMIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MULTIPROTEIN COMPLEX; PHOSPHOLIPASE C; PROTEIN E7; PROTEIN KINASE C; PROTEIN KINASE FYN; PROTEIN KINASE P60; PROTEIN P120;

EID: 78651248143     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.11.002     Document Type: Article
Times cited : (29)

References (55)
  • 2
    • 33846849466 scopus 로고    scopus 로고
    • Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway
    • G.P. Amorino, P.D. Deeble, and S.J. Parsons Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway Oncogene 26 2007 745 756
    • (2007) Oncogene , vol.26 , pp. 745-756
    • Amorino, G.P.1    Deeble, P.D.2    Parsons, S.J.3
  • 3
    • 78651251544 scopus 로고    scopus 로고
    • Cannabinoid 1 receptor-dependent transactivation of fibroblast growth factor receptor 1 emanates from lipid rafts and amplifies extracellular signal regulated kinase 1/2 activation in embryonic cortical neurons
    • in press, doi:10.1111/j.1471-4159.2010.07030.x
    • Asimaki, O., Leondaritis, G., Lois, G., Sakellaridis, N., Mangoura, D., 2010. Cannabinoid 1 receptor-dependent transactivation of fibroblast growth factor receptor 1 emanates from lipid rafts and amplifies extracellular signal regulated kinase 1/2 activation in embryonic cortical neurons. J. Neurochem., in press, doi:10.1111/j.1471-4159.2010.07030.x.
    • (2010) J. Neurochem.
    • Asimaki, O.1    Leondaritis, G.2    Lois, G.3    Sakellaridis, N.4    Mangoura, D.5
  • 4
    • 0032246648 scopus 로고    scopus 로고
    • Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist-specific trafficking of intracellular responses
    • D.W. Bonhaus, L.K. Chang, J. Kwan, and G.R. Martin Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses J. Pharmacol. Exp. Ther. 287 1998 884 888
    • (1998) J. Pharmacol. Exp. Ther. , vol.287 , pp. 884-888
    • Bonhaus, D.W.1    Chang, L.K.2    Kwan, J.3    Martin, G.R.4
  • 6
    • 0033789189 scopus 로고    scopus 로고
    • Transient suppression of cortactin ectopically induces large telencephalic neurons towards a GABAergic phenotype
    • Y. Cheng, S. Leung, and D. Mangoura Transient suppression of cortactin ectopically induces large telencephalic neurons towards a GABAergic phenotype J. Cell. Sci. 113 2000 3161 3172
    • (2000) J. Cell. Sci. , vol.113 , pp. 3161-3172
    • Cheng, Y.1    Leung, S.2    Mangoura, D.3
  • 7
    • 0034725576 scopus 로고    scopus 로고
    • Prolactin-induced cell proliferation in PC12 cells depends on JNK but not ERK activation
    • Y. Cheng, I. Zhizhin, R.L. Perlman, and D. Mangoura Prolactin-induced cell proliferation in PC12 cells depends on JNK but not ERK activation J. Biol. Chem. 275 2000 23326 23332
    • (2000) J. Biol. Chem. , vol.275 , pp. 23326-23332
    • Cheng, Y.1    Zhizhin, I.2    Perlman, R.L.3    Mangoura, D.4
  • 8
    • 0030044360 scopus 로고    scopus 로고
    • Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors
    • H. Daub, F.U. Weiss, C. Wallasch, and A. Ullrich Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors Nature 379 1996 557 560
    • (1996) Nature , vol.379 , pp. 557-560
    • Daub, H.1    Weiss, F.U.2    Wallasch, C.3    Ullrich, A.4
  • 9
    • 1542676772 scopus 로고    scopus 로고
    • A predominant role for inhibition of the adenylate cyclase/protein kinase A pathway in ERK activation by cannabinoid receptor 1 in N1E-115 neuroblastoma cells
    • M.I. Davis, J. Ronesi, and D.M. Lovinger A predominant role for inhibition of the adenylate cyclase/protein kinase A pathway in ERK activation by cannabinoid receptor 1 in N1E-115 neuroblastoma cells J. Biol. Chem. 278 2003 48973 48980
    • (2003) J. Biol. Chem. , vol.278 , pp. 48973-48980
    • Davis, M.I.1    Ronesi, J.2    Lovinger, D.M.3
  • 11
    • 48249097797 scopus 로고    scopus 로고
    • Endocannabinoids: Synthesis and degradation
    • V. Di Marzo Endocannabinoids: synthesis and degradation Rev. Physiol. Biochem. Pharmacol. 160 2008 1 24
    • (2008) Rev. Physiol. Biochem. Pharmacol. , vol.160 , pp. 1-24
    • Di Marzo, V.1
  • 12
    • 33745501378 scopus 로고    scopus 로고
    • P120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins
    • L.P. Elia, M. Yamamoto, K. Zang, and L.F. Reichardt p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins Neuron 51 1 2006 43 56
    • (2006) Neuron , vol.51 , Issue.1 , pp. 43-56
    • Elia, L.P.1    Yamamoto, M.2    Zang, K.3    Reichardt, L.F.4
  • 13
    • 33846030175 scopus 로고    scopus 로고
    • Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function
    • J. Ellis, J.D. Pediani, M. Canals, S. Milasta, and G. Milligan Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function J. Biol. Chem. 281 2006 38812 38824
    • (2006) J. Biol. Chem. , vol.281 , pp. 38812-38824
    • Ellis, J.1    Pediani, J.D.2    Canals, M.3    Milasta, S.4    Milligan, G.5
  • 14
    • 0036893729 scopus 로고    scopus 로고
    • Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor
    • I. Galve-Roperh, D. Rueda, T. Gomez del Pulgar, G. Velasco, and M. Guzman Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor Mol. Pharmacol. 62 2002 1385 1392
    • (2002) Mol. Pharmacol. , vol.62 , pp. 1385-1392
    • Galve-Roperh, I.1    Rueda, D.2    Gomez Del Pulgar, T.3    Velasco, G.4    Guzman, M.5
  • 15
    • 33845430955 scopus 로고    scopus 로고
    • Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding
    • J.C. Gatlin, A. Estrada-Bernal, S.D. Sanford, and K.H. Pfenninger Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding Mol. Biol. Cell 17 2006 5115 5130
    • (2006) Mol. Biol. Cell , vol.17 , pp. 5115-5130
    • Gatlin, J.C.1    Estrada-Bernal, A.2    Sanford, S.D.3    Pfenninger, K.H.4
  • 16
    • 1242271191 scopus 로고    scopus 로고
    • PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes
    • H. Hama, C. Hara, K. Yamaguchi, and A. Miyawaki PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes Neuron 41 2004 405 415
    • (2004) Neuron , vol.41 , pp. 405-415
    • Hama, H.1    Hara, C.2    Yamaguchi, K.3    Miyawaki, A.4
  • 17
    • 33745178510 scopus 로고    scopus 로고
    • Suppression of the phosphorylation of receptor tyrosine phosphatase-α on the Src-independent site tyrosine 789 by reactive oxygen species
    • Q. Hao, S.A. Rutherford, B. Low, and H. Tang Suppression of the phosphorylation of receptor tyrosine phosphatase-α on the Src-independent site tyrosine 789 by reactive oxygen species Mol. Pharm. 69 2006 1938 1944
    • (2006) Mol. Pharm. , vol.69 , pp. 1938-1944
    • Hao, Q.1    Rutherford, S.A.2    Low, B.3    Tang, H.4
  • 18
    • 1542510624 scopus 로고    scopus 로고
    • Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor
    • S. Hart, O.M. Fischer, and A. Ullrich Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor Cancer Res. 64 2004 1943 1950
    • (2004) Cancer Res. , vol.64 , pp. 1943-1950
    • Hart, S.1    Fischer, O.M.2    Ullrich, A.3
  • 19
    • 25844488706 scopus 로고    scopus 로고
    • The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3
    • J.C. He, I. Gomes, T. Nguyen, G. Jayaram, P.T. Ram, L.A. Devi, and R. Iyengar The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3 J. Biol. Chem. 280 2005 33426 33434
    • (2005) J. Biol. Chem. , vol.280 , pp. 33426-33434
    • He, J.C.1    Gomes, I.2    Nguyen, T.3    Jayaram, G.4    Ram, P.T.5    Devi, L.A.6    Iyengar, R.7
  • 20
    • 13244259472 scopus 로고    scopus 로고
    • Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase
    • Z. He, Y.Y. Cho, W.Y. Ma, H.S. Choi, A.M. Bode, and Z. Dong Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase J. Biol. Chem. 280 4 2005 2446 2454
    • (2005) J. Biol. Chem. , vol.280 , Issue.4 , pp. 2446-2454
    • He, Z.1    Cho, Y.Y.2    Ma, W.Y.3    Choi, H.S.4    Bode, A.M.5    Dong, Z.6
  • 21
    • 0026357750 scopus 로고
    • Characterization and localization of cannabinoid receptors in brain: An in vitro technique using slide-mounted tissue sections
    • M. Herkenham Characterization and localization of cannabinoid receptors in brain: an in vitro technique using slide-mounted tissue sections NIDA Res. Monogr. 112 1991 129 145
    • (1991) NIDA Res. Monogr. , vol.112 , pp. 129-145
    • Herkenham, M.1
  • 22
    • 0028012276 scopus 로고
    • In vitro activation of brain protein kinase C by the cannabinoids
    • C.J. Hillard, and J.A. Auchampach In vitro activation of brain protein kinase C by the cannabinoids Biochim. Biophys. Acta 1220 1994 163 170
    • (1994) Biochim. Biophys. Acta , vol.1220 , pp. 163-170
    • Hillard, C.J.1    Auchampach, J.A.2
  • 25
    • 1342322145 scopus 로고    scopus 로고
    • Translational control by MAPK signaling in long-term synaptic plasticity and memory
    • R.J. Kelleher 3rd, A. Govindarajan, H.Y. Jung, H. Kang, and S. Tonegawa Translational control by MAPK signaling in long-term synaptic plasticity and memory Cell 116 2004 467 479
    • (2004) Cell , vol.116 , pp. 467-479
    • Kelleher III, R.J.1    Govindarajan, A.2    Jung, H.Y.3    Kang, H.4    Tonegawa, S.5
  • 27
    • 62649170181 scopus 로고    scopus 로고
    • Regulation of the Ras-GTPase activating protein neurofibromin by C-tail phosphorylation: Implications for protein kinase C/Ras/extracellular signal-regulated kinase 1/2 pathway signaling and neuronal differentiation
    • G. Leondaritis, L. Petrikkos, and D. Mangoura Regulation of the Ras-GTPase activating protein neurofibromin by C-tail phosphorylation: implications for protein kinase C/Ras/extracellular signal-regulated kinase 1/2 pathway signaling and neuronal differentiation J. Neurochem. 109 2009 573 583
    • (2009) J. Neurochem. , vol.109 , pp. 573-583
    • Leondaritis, G.1    Petrikkos, L.2    Mangoura, D.3
  • 29
    • 0029778177 scopus 로고    scopus 로고
    • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβγ subunit-mediated activation of mitogen-activated protein kinases
    • DOI 10.1074/jbc.271.32.19443
    • L.M. Luttrell, B.E. Hawes, T. van Biesen, D.K. Luttrell, T.J. Lansing, and R.J. Lefkowitz Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases J. Biol. Chem. 271 1996 19443 19450 (Pubitemid 26271617)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.32 , pp. 19443-19450
    • Luttrell, L.M.1    Hawes, B.E.2    Van Biesen, T.3    Luttrell, D.K.4    Lansing, T.J.5    Lefkowitz, R.J.6
  • 30
    • 0034268796 scopus 로고    scopus 로고
    • Src tyrosine kinase is a novel direct effector of G proteins
    • Y.C. Ma, J. Huang, S. Ali, W. Lowry, and X.Y. Huang Src tyrosine kinase is a novel direct effector of G proteins Cell 102 2000 635 646
    • (2000) Cell , vol.102 , pp. 635-646
    • Ma, Y.C.1    Huang, J.2    Ali, S.3    Lowry, W.4    Huang, X.Y.5
  • 31
    • 0030708692 scopus 로고    scopus 로고
    • Mu-Opioids activate tyrosine kinase focal adhesion kinase and regulate cortical cytoskeleton proteins cortactin and vinculin in chick embryonic neurons
    • D. Mangoura mu-Opioids activate tyrosine kinase focal adhesion kinase and regulate cortical cytoskeleton proteins cortactin and vinculin in chick embryonic neurons J. Neurosci. Res. 50 1997 391 401
    • (1997) J. Neurosci. Res. , vol.50 , pp. 391-401
    • Mangoura, D.1
  • 32
    • 0027497962 scopus 로고
    • Opioid peptides activate phospholipase D and protein kinase C-epsilon in chicken embryo neuron cultures
    • D. Mangoura, and G. Dawson Opioid peptides activate phospholipase D and protein kinase C-epsilon in chicken embryo neuron cultures Proc. Natl. Acad. Sci. U.S.A. 90 1993 2915 2919
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 2915-2919
    • Mangoura, D.1    Dawson, G.2
  • 33
    • 32244437769 scopus 로고    scopus 로고
    • Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells
    • D. Mangoura, Y. Sun, C. Li, D. Singh, D.H. Gutmann, A. Flores, M. Ahmed, and G. Vallianatos Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells Oncogene 25 2006 735 745
    • (2006) Oncogene , vol.25 , pp. 735-745
    • Mangoura, D.1    Sun, Y.2    Li, C.3    Singh, D.4    Gutmann, D.H.5    Flores, A.6    Ahmed, M.7    Vallianatos, G.8
  • 34
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • C.J. Marshall Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation Cell 80 1995 179 185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 35
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • L.A. Matsuda, S.J. Lolait, M.J. Brownstein, A.C. Young, and T.I. Bonner Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 1990 561 564
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 39
    • 0027418803 scopus 로고
    • Activation of phospholipase C isozymes by G protein beta gamma subunits
    • D. Park, D.Y. Jhon, C.W. Lee, K.H. Lee, and S.G. Rhee Activation of phospholipase C isozymes by G protein beta gamma subunits J. Biol. Chem. 268 1993 4573 4576
    • (1993) J. Biol. Chem. , vol.268 , pp. 4573-4576
    • Park, D.1    Jhon, D.Y.2    Lee, C.W.3    Lee, K.H.4    Rhee, S.G.5
  • 41
    • 0030042104 scopus 로고    scopus 로고
    • Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function
    • R. Prekeris, M.W. Mayhew, J.B. Cooper, and D.M. Terrian Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function J. Cell Biol. 132 1996 77 90
    • (1996) J. Cell Biol. , vol.132 , pp. 77-90
    • Prekeris, R.1    Mayhew, M.W.2    Cooper, J.B.3    Terrian, D.M.4
  • 42
    • 0029914133 scopus 로고    scopus 로고
    • Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase
    • J.L. Rodriguez-Fernandez, and E. Rozengurt Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase J. Biol. Chem. 271 1996 27895 27901
    • (1996) J. Biol. Chem. , vol.271 , pp. 27895-27901
    • Rodriguez-Fernandez, J.L.1    Rozengurt, E.2
  • 43
    • 40949129502 scopus 로고    scopus 로고
    • MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells
    • K. Rombouts, B. Lottini, A. Caligiuri, F. Liotta, T. Mello, V. Carloni, F. Marra, and M. Pinzani MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells Exp. Cell Res. 314 2008 1444 1454
    • (2008) Exp. Cell Res. , vol.314 , pp. 1444-1454
    • Rombouts, K.1    Lottini, B.2    Caligiuri, A.3    Liotta, F.4    Mello, T.5    Carloni, V.6    Marra, F.7    Pinzani, M.8
  • 44
    • 1642450673 scopus 로고    scopus 로고
    • The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells
    • V. Rubovitch, M. Gafni, and Y. Sarne The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells Brain Res. Mol. Brain Res. 120 2004 138 144
    • (2004) Brain Res. Mol. Brain Res. , vol.120 , pp. 138-144
    • Rubovitch, V.1    Gafni, M.2    Sarne, Y.3
  • 45
    • 34548183625 scopus 로고    scopus 로고
    • Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
    • V.O. Rybin, J. Guo, Z. Gertsberg, H. Elouardighi, and S.F. Steinberg Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes J. Biol. Chem. 282 2007 23631 23638
    • (2007) J. Biol. Chem. , vol.282 , pp. 23631-23638
    • Rybin, V.O.1    Guo, J.2    Gertsberg, Z.3    Elouardighi, H.4    Steinberg, S.F.5
  • 46
  • 47
    • 36748999354 scopus 로고    scopus 로고
    • Src kinase modulates the activation, transport and signaling dynamics of fibroblast growth factor receptors
    • E. Sandilands, S. Akbarzadeh, A. Vecchione, D.G. McEwan, M.C. Frame, and J.K. Heath Src kinase modulates the activation, transport and signaling dynamics of fibroblast growth factor receptors EMBO Rep. 8 2007 1162 1169
    • (2007) EMBO Rep. , vol.8 , pp. 1162-1169
    • Sandilands, E.1    Akbarzadeh, S.2    Vecchione, A.3    McEwan, D.G.4    Frame, M.C.5    Heath, J.K.6
  • 49
    • 33746878286 scopus 로고    scopus 로고
    • Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN55,212-2
    • P. Tagliaferro, A. Javier Ramos, E.S. Onaivi, S.G. Evrard, J. Lujilde, and A. Brusco Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN55,212-2 Brain Res. 1085 2006 163 176
    • (2006) Brain Res. , vol.1085 , pp. 163-176
    • Tagliaferro, P.1    Javier Ramos, A.2    Onaivi, E.S.3    Evrard, S.G.4    Lujilde, J.5    Brusco, A.6
  • 50
    • 33746779447 scopus 로고    scopus 로고
    • The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus
    • K.A. Takahashi, and P.E. Castillo The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus Neuroscience 139 2006 795 802
    • (2006) Neuroscience , vol.139 , pp. 795-802
    • Takahashi, K.A.1    Castillo, P.E.2
  • 51
    • 56249102034 scopus 로고    scopus 로고
    • Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways
    • S. Theofilopoulos, A. Lykidis, G. Leondaritis, and D. Mangoura Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways Biochim. Biophys. Acta 1781 2008 731 742
    • (2008) Biochim. Biophys. Acta , vol.1781 , pp. 731-742
    • Theofilopoulos, S.1    Lykidis, A.2    Leondaritis, G.3    Mangoura, D.4
  • 53
    • 0034194092 scopus 로고    scopus 로고
    • Identification of PKC-isoform-specific biological actions using pharmacological approaches
    • K.J. Way, E. Chou, and G.L. King Identification of PKC-isoform-specific biological actions using pharmacological approaches Trends Pharmacol. Sci. 21 2000 181 187
    • (2000) Trends Pharmacol. Sci. , vol.21 , pp. 181-187
    • Way, K.J.1    Chou, E.2    King, G.L.3
  • 54
    • 39149136847 scopus 로고    scopus 로고
    • Reactive oxygen species mediate ERK activation through different Raf-1-dependent signaling pathways following cerebral ischemia
    • H.W. Wu, H.F. Li, X.Y. Wu, J. Zhao, and J. Guo Reactive oxygen species mediate ERK activation through different Raf-1-dependent signaling pathways following cerebral ischemia Neurosci. Lett. 432 2008 83 87
    • (2008) Neurosci. Lett. , vol.432 , pp. 83-87
    • Wu, H.W.1    Li, H.F.2    Wu, X.Y.3    Zhao, J.4    Guo, J.5
  • 55
    • 0036007287 scopus 로고    scopus 로고
    • Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation
    • R. Zeidman, U. Troller, A. Raghunath, S. Pahlman, and C. Larsson Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation Mol. Biol. Cell 13 2002 12 24
    • (2002) Mol. Biol. Cell , vol.13 , pp. 12-24
    • Zeidman, R.1    Troller, U.2    Raghunath, A.3    Pahlman, S.4    Larsson, C.5


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