Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 438-447

  Li, Jing Ran ^a,b   Li, Dong Dong ^a,b   Wang, Rong Rong ^a,b   Sun, Jian ^a,b   Dong, Jing Jun ^a,b   Du, Qian Ru ^a,b   Fang, Fei ^a,b   Zhang, Wei Ming ^a,b   Zhu, Hai Liang ^a,b  

^a Nanjing Institute for Comprehensive Utilization of Wild Plant   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

3D QSAR; Antibacterial; FabH; Molecular docking; Thiazole derivatives

Indexed keywords

2 (3 BROMOPHENYL) N (4 (4 BROMOPHENYL)THIAZOL 2 YL)ACETAMIDE; 2 (3 BROMOPHENYL) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 (3 CHLOROPHENYL) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 (3 METHOXYPHENYL) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 (3,4 DIETHOXYPHENYL) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 (4 BROMOPHENYL) N (4 (4 BROMOPHENYL)THIAZOL 2 YL)ACETAMIDE; 2 (4 BROMOPHENYL) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 (4 CHLOROPHENYL) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 (4 FLUOROPHENYL) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 PHENYL N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; ACETAMIDE DERIVATIVE; ACYLTRANSFERASE INHIBITOR; AMINE; ANTIINFECTIVE AGENT; AROMATIC CARBOXYLIC ACID; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 1 NAPHTHAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 2 (3 CHLOROPHENYL)ACETAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 2 (3 METHOXYPHENYL)ACETAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 2 (3,4 DIETHOXYPHENYL)ACETAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 2 (4 CHLOROPHENYL)ACETAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 2 (4 FLUOROPHENYL)ACETAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 2 NAPHTHAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL) 2 PHENYLACETAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL)BENZAMIDE; N (4 (4 BROMOPHENYL)THIAZOL 2 YL)MORPHOLINE 4 CARBOXAMIDE; N (4 PHENYLTHIAZOL 2 YL) 1 NAPHTHAMIDE; N (4 PHENYLTHIAZOL 2 YL) 2 NAPHTHAMIDE; N (4 PHENYLTHIAZOL 2 YL)BENZAMIDE; N (4 PHENYLTHIAZOL 2 YL)MORPHOLINE 4 CARBOXAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CHEMICAL BOND; DRUG DESIGN; DRUG SYNTHESIS; ESCHERICHIA COLI; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR MODEL; MTT ASSAY; NONHUMAN; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIMULATION; STAPHYLOCOCCUS AUREUS;

3D-QSAR; ANTIBACTERIAL; FABH; MOLECULAR DOCKING; THIAZOLE DERIVATIVES;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; DRUG DESIGN; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHASE, TYPE II; HUMANS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84896735603     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.020     Document Type: Article

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