Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues

Journal of Medicinal Chemistry

Volumn 52, Issue 6, 2009, Pages 1757-1767

  Qui, Xiao Long ^a   Li, Guideng ^a   Wu, Guikai ^a   Zhu, Jiewen ^a   Zhou, Longen ^a   Chen, Phang Lang ^a   Chamberlin, A Richard ^b   Lee, Wen Hwa ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXY 4 METHOXY N [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL] BENZAMIDE; 2 METHOXY N [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL]BENZAMIDE; 2,4 DIHYDROXY N [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL] BENZAMIDE; 2,4 DIMETHOXY N [3 METHYL 4 (2,4,TRIMETHYLPHENYL) 3H THIAZOL (2) YLIDENE]BENZAMIDE; 2,4 DIMETHOXY N METHYL N [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL]BENZAMIDE; 3 METHYL 3H IMIDAZOLE 4 CARBOXYLIC ACID [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]AMIDE; 4 (2 METHOXY 4,6 DIMETHYLPHENYL)THIAZOL 2 YLAMINE; [BENZOYL [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL] AMINO]ACETIC ACID; [BENZOYL [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL] AMINO]ACETIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; MORPHOLINE 4 CARBOXYLIC ACID [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL]AMIDE; MORPHOLINE CARBOXYLIC ACID [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]AMIDE; N [4 (2,4 DIMETHYLPHENYL)OXAZOL 2 YL]BENZAMIDE; N [4 (2,4 DIMETHYLPHENYL)OXAZOL 2 YL]THIOBENZAMIDE; N [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL] 2,4 DIMETHOXYBENZAMIDE; N [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL] N METHYLBENZAMIDE; N [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]BENZENESULFONAMIDE; N [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]C PHENYL METHANE SULFONAMIDE; N [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]ISONICOTINAMIDE; N [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]NICOTINAMIDE; N [4 (2,4,6 TRIMETHYLPHENYL)THIAZOL 2 YL]BENZAMIDE; PYRAZINE 2 CARBOXYLIC ACID [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]AMIDE; PYRIDINE 2 CARBOXYLIC ACID [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL] 2,4 DIMETHOXYBENZAMIDE; THIAZOLE 2 CARBOXYLIC ACID [4 (2,4 DIMETHYLPHENYL)THIAZOL 2 YL]AMIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 64349122715     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8015969     Document Type: Article

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