De Novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Murugan, Ravichandran N ^a   Jacob, Binu ^b   Ahn, Mija ^a   Hwang, Eunha ^a   Sohn, Hoik ^c   Park, Hyo Nam ^a   Lee, Eunjung ^d   Seo, Ji Hyung ^a   Cheong, Chaejoon ^a   Nam, Ky Youb ^e   Hyun, Jae Kyung ^a   Jeong, Ki Woong ^d   Kim, Yangmee ^d   Shin, Song Yub ^b   Bang, Jeong Kyu ^a  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b Chosun University College of Medicine   (South Korea)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d Konkuk University   (South Korea)

^e Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; HISTIDINE DERIVED ANTIMICROBIAL PEPTIDE; HISTIDINE DERIVED ANTIMICROBIAL PEPTIDE 1; HISTIDINE DERIVED ANTIMICROBIAL PEPTIDE 3; HISTIDINE DERIVED ANTIMICROBIAL PEPTIDE 4; HISTIDINE DERIVED ANTIMICROBIAL PEPTIDE 5; HISTIDINE DERIVED ANTIMICROBIAL PEPTIDE 6; NITRIC OXIDE; PEPTIDOMIMETIC AGENT; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEINASE; TRYPTOPHAN AND ARGININE RICH ANTIMICROBIAL PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; MACROPHAGE; MEMBRANE DEPOLARIZATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN STABILITY; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL LINE; DRUG DESIGN; HEMOLYSIS; HYDROCARBONS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE POTENTIALS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PROTEOLYSIS; STATIC ELECTRICITY;

EID: 84896730975     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080025     Document Type: Article

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