Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats

Journal of Ethnopharmacology

Volumn 152, Issue 2, 2014, Pages 358-363

  Tai, Ting ^a,b   Huang, Xin ^a   Su, Yuwen ^a,b   Ji, Jinzi ^a   Su, Yijing ^a   Jiang, Zhenzhou ^a   Zhang, Luyong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

CYP3A; Glycyrrhizin; Pharmacokinetics; Toxicity; Triptolide

Indexed keywords

ALPHA HYDROXYMIDAZOLAM; CYTOCHROME P450 3A; DIAZEPAM; GLYCYRRHIZIC ACID; KETOCONAZOLE; MIDAZOLAM; TRIPTOLIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ACTIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

CYP3A; GLYCYRRHIZIN; GLYCYRRHIZIN (PUBCHEM CID: 14982); KETOCONAZOLE (PUBCHEM CID: 47576); MIDAZOLAM (PUBCHEM CID: 4192); PHARMACOKINETICS; TOXICITY; TRIPTOLIDE; TRIPTOLIDE (PUBCHEM CID: 107985);

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; DITERPENES; DRUG INTERACTIONS; ENZYME INDUCTION; EPOXY COMPOUNDS; FEMALE; GLYCYRRHIZIC ACID; KETOCONAZOLE; LIVER; MALE; PHENANTHRENES; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY; TRIPTERYGIUM;

EID: 84896729990     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.01.026     Document Type: Article

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