Triptolide induces anti-inflammatory cellular responses

American Journal of Translational Research

Volumn 1, Issue 3, 2009, Pages 267-282

  Matta, Ranyia ^a   Wang, Xianxi ^b   Ge, Hui ^c   Ray, William ^a   Nelin, Leif D ^a,b   Liu, Yusen ^a,b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c ProteinOne   (United States)

Author keywords

Chinese medicine; Cytokines; Inflammation; Rheumatoid arthritis; Transcription; Tripterygium wilfordii

Indexed keywords

CHEMOKINE; COMPLEMENTARY DNA; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HEAT SHOCK TRANSCRIPTION FACTOR 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA; MICRORNA 155; PROTEIN BIC; PROTEIN PRECURSOR; PROTEIN VP16; TRANSCRIPTION FACTOR RELA; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MICROARRAY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION REGULATION;

TRIPTERYGIUM WILFORDII;

EID: 77951732252     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Chen BJ. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 2001; 42: 253-265.
2. Tao X, Cush JJ, Garret M and Lipsky PE. A phase I study of ethyl acetate extract of the chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis. J Rheumatol 2001; 28: 2160-2167.
3. Tao X, Younger J, Fan FZ, Wang B and Lipsky PE. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum 2002; 46: 1735-1743.
4. Cibere J, Deng Z, Lin Y, Ou R, He Y, Wang Z, Thorne A, Lehman AJ, Tsang IK and Esdaile JM. A randomized double blind, placebo controlled trial of topical Tripterygium wilfordii in rheumatoid arthritis: reanalysis using logistic regression analysis. J Rheumatol 2003; 30: 465-467.
5. Qiu D, Kao PN. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D 2003; 4: 1-18.
6. Liu Q, Chen T, Chen H, Zhang M, Li N, Lu Z, Ma P and Cao X. Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation. Biochem Biophys Res Commun 2004; 319: 980-986.
7. Li R-L. Summary of the second symposium of Tripterygium wilfordii. Chin J Integr Trad West Med 1991; 11: 758-760.
8. Chen JK. Lei Gong Teng (Radix Tripterygii Wilfordii): A Blessing or a Time Bomb? Acupuncture Today 2004; 5.
9. Zheng JR, Liu JH, Hsu LF, Gao JW and Jiang BL. Toxicity of total glycosides in Tripterygium wilfordii. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1983; 5: 73-78.
10. Chou WC, Wu CC, Yang PC and Lee YT. Hypovolemic shock and mortality after ingestion of Tripterygium wilfordii hook F.: a case report. Int J Cardiol 1995; 49: 173-177.
11. Chan MA, Kohlmeier JE, Branden M, Jung M and Benedict SH. Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. Phytother Res 1999; 13: 464-467.
12. Yang Y, Liu Z, Tolosa E, Yang J and Li L. Triptolide induces apoptotic death of T lymphocyte. Immunopharmacol 1998; 40: 139-149.
13. Jiang XH, Wong BC, Lin MC, Zhu GH, Kung HF, Jiang SH, Yang D and Lam SK. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene 2001; 20: 8009-8018.
14. Wang X, Matta R, Shen G, Nelin LD, Pei D and Liu Y. Mechanism of triptolide-induced apoptosis: effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. J Mol Med 6 A.D.; 84: 405-415.
15. Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC and Kao PN. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem 1999; 274: 13443-13450.
16. Shepherd EG, Zhao Q, Welty SE, Hansen TN, Smith CV and Liu Y. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. J Biol Chem 2004; 279: 54023-54031.
17. Auer H, Lyianarachchi S, Newsom D, Klisovic MI, Marcucci G and Kornacker K. Chipping away at the chip bias: RNA degradation in microarray analysis. Nat Genet 2003; 35: 292-293.
18. Barker CS, Griffin C, Dolganov GM, Hanspers K, Yang JY and Erle DJ. Increased DNA microarray hybridization specificity using sscDNA targets. BMC Genomics 2005; 6: 57.
19. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4: 249-264.
20. Hosack DA, Dennis G, Jr., Sherman BT, Lane HC and Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol 2003; 4: R70.
21. Chen P, Li J, Barnes J, Kokkonen GC, Lee JC and Liu Y. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J Immunol 2002; 169: 6408-6416.
22. Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A and Liu Y. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: Attenuation of proinflammatory cytokine biosynthesis via feedback control of p38. J Biol Chem 2005; 280: 8101-8108.
23. Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, Baliga RS, Meng X, Smith CV, Bauer JA, Chang CH and Liu Y. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med 2006; 203: 131-140.
24. Chen W, Martindale JL, Holbrook NJ and Liu Y. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Mol Cell Biol 1998; 18: 5178-5188.
25. Li J, Gorospe M, Barnes J and Liu Y. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J Biol Chem 2003; 278: 13183-13191.
26. Li J, Gorospe M, Hutter D, Barnes J, Keyse SM and Liu Y. Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. mole 2001; 21: 8213-8224.
27. Chen P, Hutter D, Yang X, Gorospe M, Davis RJ and Liu Y. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MKP-2 and their ability to catalytically activate the phosphatase. J Biol Chem 2001; 276: 29440-29449.
28. Schreiber E, Matthias P, Muller MM and Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 1989; 17: 6419.
29. Ge H, Roeder RG. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 1994; 78: 513-523.
30. Zhou R, Zheng SX, Tang W, He PL, Li XY, Yang YF, Li YC, Geng JG and Zuo JP. Inhibition of inducible nitric-oxide synthase expression by (5R)-5-hydroxytriptolide in interferon-gamma-and bacterial lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther 2006; 316: 121-128.
31. Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. Science 1993; 259: 1409-1410.
32. Wu Y, Wang Y, Zhong C, Li Y, Li X and Sun B. The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response. Int Immunopharmacol 2003; 3: 1457-1465.
33. Kupchan SM, Court WA, Dailey RG, Jr., Gilmore CJ and Bryan RF. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J Am Chem Soc 1972; 94: 7194-7195.
34. Chen BJ, Chen Y, Cui X, Fidler JM and Chao NJ. Mechanisms of tolerance induced by PG49088 in a bone marrow transplantation model. Transplantation 2002; 73: 115-121.
35. Lu Y, Fukuda K, Nakamura Y, Kimura K, Kumagai N and Nishida T. Inhibitory effect of triptolide on chemokine expression induced by proinflammatory cytokines in human corneal fibroblasts. Invest Ophthalmol Vis Sci 2005; 46: 2346-2352.
36. Zhu KJ, Shen QY, Cheng H, Mao XH, Lao LM and Hao GL. Triptolide affects the differentiation, maturation and function of human dendritic cells. Int Immunopharmacol 2005; 5: 1415-1426.
37. Chen X, Murakami T, Oppenheim JJ and Howard Z. Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic cell maturation and trafficking. Blood 2005; 106: 2409-2416.
38. Liu J, Wu QL, Feng YH, Wang YF, Li XY and Zuo JP. Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells. Acta Pharmacol Sin 2005; 26: 223-227.
39. Zhao G, Vaszar LT, Qiu D, Shi L and Kao PN. Anti-inflammatory effects of triptolide in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000; 279: L958-L966.
40. Leuenroth SJ, Crews CM. Studies on calcium dependence reveal multiple modes of action for triptolide. Chem Biol 2005; 12: 1259-1268.
41. Westerheide SD, Kawahara TL, Orton K and Morimoto RI. Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. J Biol Chem 2006; 281: 9616-9622.
42. Akira S, Kishimoto T. NF-IL6 and NF-kappa B in cytokine gene regulation. Adv Immunol 1997; 65: 1-46.
43. Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004; 25: 280-288.
44. Kim YH, Lee SH, Lee JY, Choi SW, Park JW and Kwon TK. Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase. Eur J Pharmacol 2004; 494: 1-9.
45. Wu Y, Cui J, Bao X, Chan S, Young DO, Liu D and Shen P. Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage. Int J Mol Med 2006; 17: 141-150.
46. Lee KY, Chang W, Qiu D, Kao PN and Rosen GD. PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. J Biol Chem 1999; 274: 13451-13455.
47. Zhu W, Ou Y, Li Y, Xiao R, Shu M, Zhou Y, Xie J, He S, Qiu P and Yan G. A Small Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-regulation of NF-{kappa}B Pathway. Mol Pharmacol 2009.