Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 4, 2012, Pages 713-717

  Xue, Mei ^a   Zhao, Yan ^a   Li, Xue Jun ^a   Jiang, Zhen Zhou ^b   Zhang, Liang ^c   Liu, Su Huan ^a   Li, Xiu Min ^a   Zhang, Lu Yong ^b   Yang, Shu Yu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

LC APCI MS MS; Solid lipid nanoparticles; Tissue distribution; Toxicokinetic; Triptolide

Indexed keywords

FINASTERIDE; SOLID LIPID NANOPARTICLE; TRIPTOLIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG TISSUE LEVEL; LIMIT OF DETECTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; TESTIS; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICOKINETICS;

ABSORPTION; ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; EPOXY COMPOUNDS; LIPIDS; MALE; MASS SPECTROMETRY; NANOPARTICLES; PHARMACOKINETICS; PHENANTHRENES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84866487784     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.05.012     Document Type: Article

References (17)

1. B.J. Chen Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F Leuk. Lymphoma 42 2001 253 265
2. U. Dhana lekshmi, G. Poovi, N. Kishore, and P.N. Reddy In vitro characterization and invivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles Int. J. Pharma. 396 2010 194 203
3. A.P. Hikim, Y.H. Lue, C. Wang, V. Reutrakul, R. Sangsuwan, and R.S. Swerdloff Posttesticular antifertility action of triptolide in the male rat: evidence for severe impairment of cauda epididymal sperm ultrastructure J. Androl. 21 2000 431 437
4. P.N. Huynh, A.P. Hikim, C. Wang, K. Stefonovic, Y.H. Lue, A. Leung, V. Atienza, S. Baravarian, V. Reutrakul, and R.S. Swerdloff Long-term effects of triptolide on spermatogenesis, epididymal sperm function, and fertility in male rats J. Androl. 21 2000 689 699
5. J. Li, Y. Lu, C. Xiao, C. Lu, X. Niu, X. He, H. Zhao, Y. Tan, and A. Lu Comparison of toxic reaction of tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats J. Ethnopharmacol. 135 2011 270 277
6. P.E. Lipsky, and X.L. Tao A potential new treatment for rheumatoid arthritis: thunder god vine Semin. Arthritis Rheum. 26 1997 713 723
7. M. Liu, J. Dong, Y. Yang, X. Yang, and H. Xu Anti-inflammatory effects of triptolide loaded poly (d, l-lactic acid) nanoparticles on adjuvant-induced arthritis in rats J. Ethnopharmacol. 97 2005 219 225
8. Z. Mei, X. Li, Q. Wu, S. Hu, and X. Yang The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle Pharmacol. Res. 51 2005 345 351
9. Xue Mei, J. Jiang, Wu. Tao, Ming. Yan, Ji-Ping Liu, Mu. Xian-Min, Su. Yu-Wen, and Lu-Yong Zhang Protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats Arzneimittelforschung 61 2011 1 6
10. T. Panichakul, P. Intachote, A. Wongkajorsilp, B. Sripa, and S. Sirisinha Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis Anticancer Res. 26 2006 259 265
11. D. Paolino, D. Cosco, F. Cilurzo, and M. Fresta Innovative drug delivery systems for the administration of natural compounds Curr. Bioact. Compd. 3 2007 262 277
12. S. Saraf Ajazuddin Applications of novel drug delivery system for herbal formulations Fitoterapia 81 2010 680 689
13. Z. Wang, H. Jin, C. Li, Y. Hou, Q. Mei, and D. Fan Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway Int. J. Toxicol. 28 2009 177 189
14. L. Xu, H. Chen, H. Xu, and X. Yang Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles Eur. J. Pharm. Biopharm. 70 2008 741 748
15. L.L. Yang, X. Zhang, and Y.S. Yuan Chin. J. Chromatogr. 19 2001 58 59
16. S. Yang, J. Chen, Z. Guo, X.M. Xu, L. Wang, X.F. Pei, J. Yang, C.B. Underhill, and L. Zhang Triptolide inhibits the growth and metastasis of solid tumors Mol. Cancer Ther. 2 2003 65 72
17. J. Yao, Z. Jiang, W. Duan, J. Huang, L. Zhang, L. Hu, L. He, F. Li, Y. Xiao, B. Shu, and C. Liu Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells Biol. Pharm. Bull. 31 2008 592 597