Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats

Drug and Chemical Toxicology

Volumn 34, Issue 1, 2011, Pages 1-7

  Liu, Jing ^a   Jiang, Zhenzhou ^a,b   Liu, Li ^a,c   Zhang, Yun ^a   Zhang, Shuang ^a   Xiao, Jingwei ^a   Ma, Min ^a   Zhang, Luyong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Key Laboratory of Drug Quality Control and Pharmacovigilance   (China)

^c YANGZHOU UNIVERSITY   (China)

Author keywords

ER ; hormones; Estrous cycle; Female rats; Reproductive parameters; Triptolide

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FOLLITROPIN; LUTEINIZING HORMONE; PROGESTERONE; TRIPTOLIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG MECHANISM; ENZYME IMMUNOASSAY; ESTRADIOL BLOOD LEVEL; ESTROGEN ACTIVITY; ESTRUS CYCLE; FEMALE; FEMALE GENITAL SYSTEM; FOLLITROPIN BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LD 50; LOW DRUG DOSE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MEDICINAL PLANT; NONHUMAN; OVARY; OVARY FOLLICLE; PROGESTERONE BLOOD LEVEL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; RAT; REPRODUCTIVE TOXICITY; SPRAGUE DAWLEY RAT; TRIPTERGIUM WILDFORDII HOOK.F; UTERUS; UTERUS WEIGHT; VAGINA SMEAR;

ANIMALS; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROUS CYCLE; FEMALE; FOLLICLE STIMULATING HORMONE; IMMUNOHISTOCHEMISTRY; LUTEINIZING HORMONE; ORGAN SIZE; OVARY; PHENANTHRENES; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; UTERUS;

ANIMALIA; RATTUS;

EID: 78649948349     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480541003774358     Document Type: Article

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