Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat

Toxicology Letters

Volumn 192, Issue 2, 2010, Pages 212-220

  Ye, Xiaochuan ^a   Li, Wenyuan ^a   Yan, Yan ^a   Mao, Chengwen ^a   Cai, Ruxiu ^b   Xu, Huibi ^a   Yang, Xiangliang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Dexamethasone; Hepatotoxicity; Metabolism; Nephrotoxicity; Triptolide

Indexed keywords

DEXAMETHASONE; DRUG METABOLITE; TRIPTOLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG METABOLISM; DRUG STRUCTURE; KIDNEY INJURY; LIVER MICROSOME; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT;

ANIMALS; BIOLOGICAL MARKERS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DITERPENES; EPOXY COMPOUNDS; KIDNEY; LIVER; MALE; MICROSOMES, LIVER; PHENANTHRENES; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

RATTUS; TRIPTERYGIUM WILFORDII;

EID: 73749084404     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.10.028     Document Type: Article

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