Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: Study in juvenile diabetic rat

Chemico-Biological Interactions

Volumn 213, Issue 1, 2014, Pages 1-12

  Khan, S ^a   Jena, G B ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Apoptosis; Beta cell proliferation; Glucose homeostasis; HDAC inhibitor; p38 MAPK pathway; Sodium butyrate

Indexed keywords

BUTYRIC ACID; CASPASE 3; CITRIC ACID; CYCLINE; GLUCOSE; HEMOGLOBIN A1C; HISTONE DEACETYLASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR FKHR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HEMOGLOBIN BLOOD LEVEL; HISTONE ACETYLATION; HISTOPATHOLOGY; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; JUVENILE ANIMAL; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PROTECTION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION;

APOPTOSIS; BETA-CELL PROLIFERATION; GLUCOSE HOMEOSTASIS; HDAC INHIBITOR; P38/MAPK PATHWAY; SODIUM BUTYRATE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BODY WEIGHT; BUTYRIC ACID; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; HISTONE DEACETYLASE INHIBITORS; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84896715452     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.02.001     Document Type: Article

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