The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression

Stem Cells

Volumn 25, Issue 12, 2007, Pages 3223-3233

  Mutskov, Vesco ^a   Raaka, Bruce M ^a   Felsenfeld, Gary ^a   Gershengorn, Marvin C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Epigenetic; Histone modifications; Insulin gene; Islet derived precursor cells; Mesenchymal stromal cells

Indexed keywords

HISTONE H3; HISTONE H4; INSULIN; LYSINE;

ACETYLATION; ARTICLE; CELL DIVISION; CELL POPULATION; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DNA MODIFICATION; EPITHELIUM CELL; GENE ACTIVATION; GENE LOCUS; GENETIC MARKER; GENETIC TRANSCRIPTION; HELA CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MESENCHYMAL STEM CELL; METHYLATION; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PHENOTYPE; PROTEIN MODIFICATION; STEM CELL TRANSPLANTATION;

BONE MARROW CELLS; CELL PROLIFERATION; CELL SEPARATION; CELLS, CULTURED; CHROMATIN; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENETIC MARKERS; HELA CELLS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MESENCHYMAL STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 37349051445     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0325     Document Type: Article

References (39)

1. Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid free immunosuppressive regimen. N Engl J Med 2000;343:230-238.
2. Shapiro AM, Ricordi C, Hering BJ et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006;355:1318-1330.
3. Naftanel MA, Harlan DM. Pancreatic islet transplantation. PLoS Med 2004;1:e58.
4. Dor Y, Brown J, Martinez OI at al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46.
5. Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: Potential for the treatment of diabetes mellitus. Am J Physiol Endocrinol Metab 2003;284:E259-E266.
6. Gershengorn MC, Geras-Raaka E, Hardikar AA. Are better islet cell precursors generated by epithelial-to-mesenchymal transition? Cell Cycle 2005;4:380-382.
7. Gershengorn MC, Hardikar AA, Wei C at al. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 2004;306:2261-2264.
8. Davani B, Ikonomou L, Raaka BM, et al. Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. STEM CELLS 2007;25:3215-3222.
9. Melloul D, Marshak S, Cerasi E. Regulation of insulin gene transcription. Diabetologia 2002;45:309-326.
10. Ohneda K, Ee H, German M. Regulation of insulin gene transcription. Semin Cell Dev Biol 2000;11:227-233.
11. Mutskov VJ, Farrell CM, Wade PA et al. The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev 2002;16:1540-1554.
12. Mutskov V, Felsenfeld G. Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J 2004;23:138-149.
13. Clayton AL, Hazzalin CA, Mahadevan LC. Enhanced histone acetylation and transcription: A dynamic perspective. Mol Cell 2006;23:289-296.
14. Nightingale KP, O'Neill LP, Turner BM. Histone modifications: Signalling receptors and potential elements of a heritable epigenetic code. Curr Opin Genet Dev 2006;16:125-136.
15. Sims RJ 3rd, Reinberg D. Histone H3 Lys 4 methylation: Caught in a bind? Genes Dev 2006;20:2779-2786.
16. Litt MD, Simpson M, Gaszner M et al. Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science 2001;293:2453-2455.
17. Kondo Y, Shen L, Issa JP. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol 2003;23:206-215.
18. Nguyen CT, Weisenberger DJ, Velicescu M et al. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-Aza-2′-deoxycytidine. Cancer Res 2002;62:6456-6461.
19. Nielsen SJ, Schneider R, Bauer UM et al. Rb targets histone H3 methylation and HP1 to promoters. Nature 2001;412:561-565.
20. Chen LB, Jiang XB, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World J Gastroenterol 2004;10:3016-3020.
21. Choi KS, Shin JS, Lee JJ et al. In vitro trans-differentiation of rat mesenchymal cells into insulin-producing cells by rat pancreatic extract. Biochem Biophys Res Commun 2005;330:1299-1305.
22. Moriscot C, de Fraipont F, Richard MJ et al. Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. STEM CELLS 2005;23:594 -603.
23. Tang DQ, Cao LZ, Burkhardt BR et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004;53:1721-1732.
24. Berger SL. Histone modifications in transcriptional regulation. Curr Opin Genet Dev 2002;12:142-148.
25. Felsenfeld G, Groudine M. Controlling the double helix. Nature 2003;421:448-453.
26. Turner BM. Cellular memory and the histone code. Cell 2002;111:285-291.
27. Mosley AL, Ozcan S. Glucose regulates insulin gene transcription by hyperacetylation of histone H4. J Biol Chem 2003;278:19660-19666.
28. Chakrabarti SK, Francis J, Ziesmann SM et al. Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem 2003;278:23617-23623.
29. Bernstein BE, Kamal M, Lindblad-Toh K et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 2005;120:169-181.
30. Pokholok DK, Harbison CT, Levine S et al. Genome wide map of nucleosome acetylation and methylation in yeast. Cell 2005;122:517-527.
31. Schubeler D, MacAlpine DM, Scalzo D et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev 2004;18:1263-1271.
32. Vakoc CR, Mandat SA, Olenchock BA et al. Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell 2005;19:381-391.
33. Hake SB, Allis CD. Histone H3 variants and their potential role in indexing mammalian genomes: The "H3 barcode hypothesis." Proc Natl Acad Sci U S A 2006;103:6428-6435.
34. Ringrose L, Paro R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet 2004;38:413-443.
35. Gan Q, Yoshida T, McDonald OG et al. Epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells. STEM CELLS 2007;25:2-9.
36. Roloff TC, Nuber UA. Chromatin, epigenetics and stem cells. Eur J Cell Biol 2005;84:123-135.
37. Szutorisz H, Dillon N. The epigenetic basis for embryonic stem cell pluripotency. Bioessays 2005;27:1286-1293.
38. Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006;125:315-326.
39. Higgs DR, Vernimmen D, De Gobbi M et al. How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation. Biochem Soc Symp 2006;73:11-22.