Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice

Behavioural Brain Research

Volumn 264, Issue , 2014, Pages 34-42

  Kennard, John A ^a   Harrison, Fiona E ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aging; Alzheimer's disease; APP PSEN1; Dopamine; Modified Y maze; Spatial memory; Vitamin C

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ASCORBIC ACID; DOPAMINE; PRESENILIN 1; SODIUM ASCORBIC ACID COTRANSPORTER; SODIUM ASCORBIC ACID COTRANSPORTER 1; SODIUM ASCORBIC ACID COTRANSPORTER 2; UNCLASSIFIED DRUG;

ADULT; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOROID PLEXUS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG UPTAKE; MIDDLE AGED; MOUSE; NEUROPATHOLOGY; NONHUMAN; NUCLEUS ACCUMBENS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SHORT TERM MEMORY; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SPATIAL MEMORY; TASK PERFORMANCE; WILD TYPE; Y-MAZE TEST; YOUNG ADULT;

AGING; ALZHEIMER'S DISEASE; APP/PSEN1; DOPAMINE; MODIFIED Y-MAZE; SPATIAL MEMORY; VITAMIN C;

ADMINISTRATION, INTRAVENOUS; AGE FACTORS; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROTRANSMITTER AGENTS; PEPTIDE FRAGMENTS; PRESENILIN-1; SPACE PERCEPTION; TIME FACTORS;

EID: 84896708850     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.01.044     Document Type: Article

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