Ascorbic acid: A promising memory-enhancer in mice

Journal of Pharmacological Sciences

Volumn 93, Issue 2, 2003, Pages 129-135

  Parle, Milind ^a   Dhingra, Dinesh ^a  

^a GURU JAMBHESHWAR UNIVERSITY OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Ascorbic acid; Memory; Piracetam; Scopolamine

Indexed keywords

ASCORBIC ACID; DIAZEPAM; PIRACETAM; SCOPOLAMINE;

AGED; AGING; ALZHEIMER DISEASE; AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEMENTIA; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INDICATION; DRUG MECHANISM; DRUG POTENCY; FEMALE; LATENT PERIOD; LEARNING; MALE; MAZE TEST; MEMORY; MEMORY DISORDER; MODEL; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PROTECTION;

AGING; AMNESIA; ANIMALS; ANTIOXIDANTS; ANXIETY; ASCORBIC ACID; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; DIAZEPAM; EMOTIONS; FEMALE; GABA MODULATORS; MALE; MAZE LEARNING; MEMORY; MICE; MOTOR ACTIVITY; MUSCARINIC ANTAGONISTS; NOOTROPIC AGENTS; PIRACETAM; SCOPOLAMINE;

EID: 0242720574     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.93.129     Document Type: Article

References (24)

1. Nagy IZ. On the true role of oxygen free radicals in the living state, aging and degenerative disorders. Ann NY Acad Sci. 2001;928:187-199.
2. Guerrero AL, Dorada-Martinez C, Rodriguez A, Pedroza-Rios K, Borgonio-Perez G, Rivas-Arancibia S. Effects of vitamin E on ozone-induced memory deficits and lipid peroxidation in rats. Neuroreport. 1999;10:1689-1692.
3. Morris MC, Evans DA, Bienias JL, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer's disease in a biracial community study. JAMA. 2002;287:3230-3237.
4. Adam K. Lack of effect on mental efficiency of extra vitamin C. Am J Clin Nutr. 1981;34:1712-1716.
5. DeAngelis L, Furlan C. The effects of ascorbic acid and oxiracetam on scopolamine induced amnesia in a habituation test in aged-mice. Neurobiol Learn Mem. 1995;64:119-124.
6. Higashida A, Ogawa N. Differences in the acquisition process and the effect of scopolamine on radial maze performance in the strains of rats. Pharmacol Biochem Behav. 1987;27:483-489.
7. Sitaram N, Weingartner H, Gillin JC. Human serial learning. Enhancement with arecholine and choline and impairment with scopolamine. Science. 1978;201:247-276.
8. Preston C, Ward C, Lines CR, Poppleton P, Haigh JRM, Traub M. Scopolamine and benzodiazepine models of dementia: Reversal by RO-15-1788 and physostigmine. Psychopharmacology (Berl). 1989;98:487-494.
9. Singh N, Sharma A, Singh M. Possible mechanism of alprazolam-induced amnesia in mice. Pharmacology. 1998;56:46-50.
10. Lister RG. The amnesic action of benzodiazepines in man. Neurosci Biobehav Rev. 1985;9:87-94.
11. Itoh J, Nabeshima T, Kameyama T. Utility of an elevated plus maze for the evaluation of nootropics, scopolamine and electro convulsive shock. Psychopharmacology (Berl). 1990;101:27-33.
12. Reddy DS, Kulkarni SK. Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging and dizocilpine-induced learning impairment. Brain Res. 1998;799:215-229.
13. Veerendra Kumar MH, Gupta YK. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. J Ethnopharmacol. 2002;79:253-260.
14. Dhingra D, Parle M, Kulkarni SK. Effect of combination of insulin with dextrose, D (-)-fructose and diet on learning and memory in mice. Indian J Pharmacol. 2003;35:151-156.
15. Sinclair AJ, Bayer AJ, Johnston J, Warner C, Maxwell SR. Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia. Int J Geriatr Psychiatry. 1998;13:840-855.
16. Jensen LH, Stephens DN, Sarter M, Petersen EN. Bidirectional effects of beta-carbolines and benzodiazepines on memory processes. Brain Res Bull. 1987;19:359-364.
17. Tariska P, Paksy A. Cognitive enhancement effect of piracetam in patients with mild cognitive impairment and dementia. Orv Hetil. 2000;141:1189-1193.
18. Canonico PL, Aronica E, Aleppo G, et al. Repeated injections of piracetam improve spatial learning and increase the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in aged rats. Funct Neurol. 1991;6:107-111.
19. Bhattacharya SK, Upadhyay SN, Jaiswal AK. Effect of piracetam on electroshock induced amnesia and decrease in brain acetylcholine in rats. Indian J Exp Biol. 1993;31:822-824.
20. Agus DB, Gambhir SS, Pardridge WM, et al. Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J Clin Invest. 1997;100:2842-2848.
21. Huang J, Agus DB, Winfree CJ, et al. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc Natl Acad Sci USA. 2001;98:11720-11724.
22. Jones RB, Satterlee DG, Cadd GG. Timidity in Japanese quail: Effects of vitamin C and divergent selection for adrenocortical response. Physiol Behav. 1999;67:117-120.
23. Sayre LM, Zagorski MG, Surewicz WK, Krafft GA, Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: A critical appraisal. Chem Res Toxicol. 1997;336:1216-1222.
24. Bickford PC, Gould T, Briederick L, et al. Antioxidants-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res. 2000;866:211-217.