Self-injurious behaviour in autistic children: A neuro-developmental theory of social and environmental isolation

Psychopharmacology

Volumn 231, Issue 6, 2014, Pages 979-997

  Devine, Darragh P ^a  

^a University of Florida ^*  (United States)

Author keywords

Animal model; Anxiety; Autism; Environmental deprivation; Limbic system; Romanian orphanage; Self injurious behaviour; Socialization; Stereotypy; Stress

Indexed keywords

ANXIETY; AUTISM; AUTOMUTILATION; BASAL GANGLION; CHILD; COMORBIDITY; ENVIRONMENTAL DEPRIVATION; ENVIRONMENTAL FACTOR; HUMAN; LIMBIC CORTEX; LIMBIC SYSTEM; NERVE CELL DIFFERENTIATION; NEUROANATOMY; NEUROCHEMISTRY; NEUROPHYSIOLOGY; ORPHANAGE; PRIORITY JOURNAL; REVIEW; RHESUS MONKEY; SOCIAL ISOLATION; SOCIALIZATION; STRESS;

ANIMALS; AUTISTIC DISORDER; BRAIN; CHILD; ENVIRONMENT; HUMANS; MODELS, NEUROLOGICAL; SELF-INJURIOUS BEHAVIOR; SOCIAL ISOLATION;

EID: 84896707085     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3279-2     Document Type: Review

References (230)

1. Aman MG, Arnold LE, McDougle CJ, Vitiello B, Scahill L, Davies M, McCracken JT, Tierney E, Nash PL, Posey DJ, Chuang S, Martin A, Shah B, Gonzalez NM, Swiezy NB, Ritz L, Koenig K, McGough J, Ghuman JK, Lindsay RL (2005) Acute and long-term safety and tolerability of risperidone in children with autism. J Child Adolesc Psychopharmacol 15:869-884 (Pubitemid 43042978)
2. Aman MG, McDougle CJ, Scahill L, Handen B, Arnold LE, Johnson C, Stigler KA, Bearss K, Butter E, Swiezy NB, Sukhodolsky DD, Ramadan Y, Pozdol SL, Nikolov R, Lecavalier L, Kohn AE, Koenig K, Hollway JA, Korzekwa P, Gavaletz A, Mulick JA, Hall KL, Dziura J, Ritz L, Trollinger S, Yu S, Vitiello B, Wagner A (2009) Medication and parent training in childrenwith pervasive developmental disorders and serious behavior problems: results from a randomized clinical trial. J Am Acad Child Adolesc Psychiatry 48:1143-1154
3. Ando H, Yoshimura I (1979) Speech skill levels and prevalence of maladaptive behaviors in autistic and mentally retarded children: a statistical study. Child Psychiatry Hum Dev 10:85-90 (Pubitemid 10219182)
4. Archer DC, Pinchbeck GL, French NP, Proudman CJ (2008) Risk factors for epiploic foramen entrapment colic in a UK horse population: a prospective case-control study. Equine Vet J 40:405-410 (Pubitemid 351881592)
5. Arron K, Oliver C, Moss J, Berg K, Burbidge C (2011) The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes. J Intellect Disabil Res 55:109-120
6. Autism and Developmental Disabilities Monitoring Network (2012) Prevalence of autism spectrum disorders. MMWR Surveill Summ 61:1-19
7. Baghdadli A, Pascal C, Grisi S, Aussilloux C (2003) Risk factors for self-injurious behaviours among 222 young children with autistic disorders. J Intellect Disabil Res 47:622-627 (Pubitemid 37406883)
8. Bailey A, Luthert P, Dean A, Harding B, Janota I, Montgomery M, Rutter M, Lantos P (1998) A clinicopathological study of autism. Brain 121(Pt 5):889-905 (Pubitemid 28220896)
9. Baranek GT (1999) Autism during infancy: a retrospective video analysis of sensory-motor and social behaviors at 9-12 months of age. J Autism Dev Disord 29:213-224
10. Baranek GT, David FJ, Poe MD, Stone WL, Watson LR (2006) Sensory Experiences Questionnaire: discriminating sensory features in young children with autism, developmental delays, and typical development. J Child Psychol Psychiatry 47:591-601 (Pubitemid 43744790)
11. Barnea-Goraly N, Kwon H, Menon V, Eliez S, Lotspeich L, Reiss AL (2004) White matter structure in autism: preliminary evidence from diffusion tensor imaging. Biol Psychiatry 55:323-326 (Pubitemid 38117172)
12. Barr CS, Newman TK, Becker ML, Parker CC, Champoux M, Lesch KP, Goldman D, Suomi SJ, Higley JD (2003) The utility of the nonhuman primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav 2:336-340 (Pubitemid 37463198)
13. Barr CS, Newman TK, Shannon C, Parker C, Dvoskin RL, Becker ML, Schwandt M, Champoux M, Lesch KP, Goldman D, Suomi SJ, Higley JD (2004) Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry 55:733-738 (Pubitemid 38376185)
14. Bartak L, Rutter M (1976) Differences between mentally retarded and normally intelligent autistic children. J Autism Child Schizophr 6: 109-120
15. Bauman M, Kemper TL (1985) Histoanatomic observations of the brain in early infantile autism. Neurol 35:866-874 (Pubitemid 15025292)
16. Baumeister AA, Frye GD (1984) Self-injurious behavior in rats produced by intranigral microinjection of GABA agonists. Pharmacol Biochem Behav 21:89-95 (Pubitemid 14085601)
17. Bayne K, Dexter S, Suomi S (1992) A preliminary surrvey of the incidence of abnormal behavior in rhesus monkeys (Macaca mulatta) relative to housing conditions. Lab Anim 21:38-46
18. Beckett C, Bredenkamp D, Castle J, Groothues C, O'Connor TG, Rutter M (2002) Behavior patterns associated with institutional deprivation: a study of children adopted from Romania. Dev Behav Pediatr 23:297-303 (Pubitemid 35244139)
19. Behen ME, Muzik O, Saporta AS, Wilson BJ, Pai D, Hua J, Chugani HT (2009) Abnormal fronto-striatal connectivity in children with histories of early deprivation: a diffusion tensor imaging study. Brain Imaging Behav 3:292-297
20. Biersdorff KK (1991) Pain insensitivity and indifference: alternative explanations for some medical catastrophes. Ment Retard 29:359-362
21. Biersdorff KK (1994) Incidence of significantly altered pain experience among individuals with developmental disabilities. Am J Ment Retard 98:619-631
22. Blake BL, Muehlmann AM, Egami K, Breese GR, Devine DP, Jinnah HA (2007) Nifedipine suppresses self-injurious behaviors in animals. Dev Neurosci 29:241-250 (Pubitemid 46355593)
23. Blundell J, Blaiss CA, Etherton MR, Espinosa F, Tabuchi K, Walz C, Bolliger MF, Sudhof TC, Powell CM (2010) Neuroligin-1 deletion results in impaired spatialmemory and increased repetitive behavior. J Neurosci 30:2115-2129
24. Bodfish JW, Crawford TW, Powell SB, Parker DE, Golden RN, Lewis MH (1995) Compulsions in adults with mental retardation: prevalence, phenomenology, and comorbidity with stereotypy and selfinjury. Am J Ment Retard 100:183-192
25. Bodfish JW, McCuller WR, Madison JM, Register M, Mailman RB, Lewis MH (1997) Placebo, double-blind evaluation of long-term naltrexone treatment effects for adults with mental retardation and self-injury. J Dev Phys Disabil 9:135-152
26. Borthwick SA, Meyers CE, Eyman RK (1981) Comparative adaptive and maladaptive behavior of mentally retarded clients of five residential settings in three Western states. Monogr Am Assoc Ment Defic 351-359
27. Borthwick-Duffy SA (1994) Prevalence of destructive behaviors: a study of aggression, self-injury, and property destruction. In: Thompson T, Gray DB (eds) Destructive behavior in developmental disabilities: diagnosis and treatment. Sage Publishing, Thousand Oaks, pp 3-23
28. Boyd BA, Baranek GT, Sideris J, Poe MD, Watson LR, Patten E, Miller H (2010) Sensory features and repetitive behaviors in children with autism and developmental delays. Autism Res 3:78-87
29. Brahm NC, Fast GA, Brown RC (2008) Buspirone for autistic disorder in a woman with an intellectual disability. Ann Pharmacother 42:131-137
30. Breau LM, Camfield CS, Symons FJ, Bodfish JW, Mackay A, Finley GA, McGrath PJ (2003) Relation between pain and self-injurious behavior in nonverbal children with severe cognitive impairments. J Pediatr 142:498-503 (Pubitemid 36623558)
31. Breese GR, Baumeister AA, McCown TJ, Emerick SG, Frye GD, Mueller RA (1984) Neonatal-6-hydroxydopamine treatment: model of susceptibility for self-mutilation in the Lesch-Nyhan syndrome. Pharmacol Biochem Behav 21:459-461 (Pubitemid 14015663)
32. Breese GR, Baumeister AA, Napier TC, Frye GD, Mueller RA (1985) Evidence that D-1 dopamine receptors contribute to the supersensitive behavioral responses induced by l-dihydroxyphenylalanine in rats treated neonatally with 6-hydroxydopamine. J Pharmacol & Exp Ther 235: 287-295 (Pubitemid 16248716)
33. Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL (2005) The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles. Brain Res Brain Res Rev 48:57-73 (Pubitemid 40215783)
34. Bromley J, Emerson E (1995) Beliefs and emotional reactions of care staff working with people with challenging behaviour. J Intellect Disabil Res 39(Pt 4):341-352
35. Caixeta M, Caixeta L (2005) Topiramato reduz irritabilidade e automutilação em crianças autistas [Topiramate reduces irritability and self-injuries in autistic children-Portugese]. Rev Bras Psiquiatr 27:345-346 (Pubitemid 43154997)
36. Calabresi P, Pisani A, Mercuri NB, Bernardi G (1996) The corticostriatal projection: from synaptic plasticity to dysfunctions of the basal ganglia. Trends Neurosci 19:19-24 (Pubitemid 26014822)
37. Campbell M, Rapoport JL, Simpson GM (1999) Antipsychotics in children and adolescents. J Am Acad Child Adolesc Psychiatry 38:537-545 (Pubitemid 29203469)
38. Canitano R (2005) Self injurious behavior in autism: clinical aspects and treatment with risperidone. J Neural Transm 113:425-431
39. Canitano R, Scandurra V (2011) Psychopharmacology in autism: an update. Prog Neuropsychopharmacol Biol Psychiatry 35:18-28
40. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-389 (Pubitemid 36877077)
41. Champoux M, Bennett A, Shannon C, Higley JD, Lesch KP, Suomi SJ (2002) Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Mol Psychiatry 7: 1058-1063 (Pubitemid 36044264)
42. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM (2010) TPH2 5′- and 3′-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys. Genes Brain Behav 9:335-347
43. Chengappa KN, Suppes T, Berk M (2004) Treatment of bipolar mania with atypical antipsychotics. Expert Rev Neurother 4:S17-S25 (Pubitemid 39482260)
44. Chugani HT, Behen ME, Muzik O, Juhasz C, Nagy F, Chugani DC (2001) Local brain functional activity following early deprivation: a study of postinstitutionalized Romanian orphans. Neuroimage 14:1290-1301 (Pubitemid 33124177)
45. Consensus Statement NIH (1989) Treatment of destructive behaviors in persons with developmental disabilities. J Autism Dev Disord 20: 403-429
46. Corbett BA, Mendoza S, Abdullah M, Wegelin JA, Levine S (2006) Cortisol circadian rhythms and response to stress in children with autism. Psychoneuroendo 31:59-68 (Pubitemid 41668895)
47. Crair MC, Gillespie DC, Stryker MP (1998) The role of visual experience in the development of columns in cat visual cortex. Science 279:566-570 (Pubitemid 28067286)
48. Cromwell HC, Witte EA, Crawford CA, Ly HT, Maidment NT, King BH (1996) Pemoline produces ipsilateral turning behavior in unilateral 6-OHDA-lesioned rats. Prog Neuropsychopharmacol Biol Psychiatry 20:503-514 (Pubitemid 26168827)
49. Cromwell HC, King BH, Levine MS (1997) Pemoline alters dopamine modulation of synaptic responses of neostriatal neurons in vitro. Dev Neurosci 19:497-504 (Pubitemid 27522440)
50. Cromwell HC, Levine MS, King BH (1999) Cortical damage enhances pemoline-induced self-injurious behavior in prepubertal rats. Pharmacol Biochem Behav 62:223-227 (Pubitemid 29070884)
51. Crosland KA, Zarcone JR, Lindauer SE, Valdovinos MG, Zarcone TJ, Hellings JA, Schroeder SR (2003) Use of functional analysis methodology in the evaluation of medication effects. J Autism Dev Disord 33:271-279 (Pubitemid 36919118)
52. Cross HA, Harlow HF (1965) Prolonged and progressive effects of partial isolation on the behavior of macaquemonkeys. J Exp Res Pers 1:39-49
53. Davenport MD, Lutz CK, Tiefenbacher S, Novak MA, Meyer JS (2008) A rhesus monkey model of self-injury: effects of relocation stress on behavior and neuroendocrine function. Biol Psychiatry 63:990-996
54. Dawson G (2008) Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder. Dev Psychopathol 20:775-803
55. Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Donaldson A, Varley J (2010) Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model. Pediatrics 125:e17-e23
56. Devine DP (2012a) Animal models of self-injurious behaviour: an overview. In: Kobeissy FH (ed) Psychiatric disorders: methods and protocols. Humana Press, New York, pp 65-84
57. Devine DP (2012b) The pemoline model of self-injurious behaviour. In: Kobeissy FH (ed) Psychiatric disorders: methods and protocols. Humana Press, New York, pp 155-163
58. Devine DP, Symons FJ (2013) Biological vulnerability and risk for self-injury in intellectual and developmental disabilities. In: Hastings R, Rojahn J (eds) International review of research in developmental disabilities: challenging behavior. Academic Press, New York, pp 37-68
59. Dixon PM, Dacre I (2005) A review of equine dental disorders. Vet J 169: 165-187 (Pubitemid 40277289)
60. Dodman NH, Normile JA, Shuster L, Rand W (1994) Equine self-mutilation syndrome (57 cases). J Am Vet Med Assoc 204:1219-1223
61. Dominick KC, Davis NO, Lainhart J, Tager-Flusberg H, Folstein S (2006) Atypical behaviors in children with autism and children with a history of language impairment. Res Dev Disabil 28:145-162
62. Eapen V, Crncec R, Walter A (2013) Clinical outcomes of an early intervention program for preschool children with Autism Spectrum Disorder in a community group setting. BMC Pediatr 13:1-9
63. Eluvathingal TJ, Chugani HT, Behen ME, Juhasz C, Muzik O, Maqbool M, Chugani DC, Makki M (2006) Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study. Pediatrics 117:2093-2100 (Pubitemid 46071255)
64. Epstein LJ, Taubman MT, Lovaas OI (1985) Changes in self-stimulatory behaviors with treatment. J Abnorm Child Psychol 13:281-293 (Pubitemid 15053687)
65. Eriksson PS, Hansson E, Rönnbäck L (1991) Mu and delta opiate receptors in neuronal and astroglial primary cultures from various regions of the brain-coupling with adenylate cyclase, localisation on the same neurones and association with dopamine (D1) receptor adenylate cyclase. Neuropharmacol 30:1233-1239
66. Etherton MR, Blaiss CA, Powell CM, Sudhof TC (2009) Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A 106:17998-18003
67. Everett GM (1976) Comparative pharmacology of amphetamine and pemoline on biogenic amine systems. Fed Proc 35:405
68. Favell JE, Azrin NA, Baumeister AA, Carr EG, Dorsey MF, Forehand R, Foxx RM, Lovaas OI, Rincover A, Risley T, Romanczyk RG, Russo DC, Schroeder SR, Solnick JV (1982) The treatment of self-injurious behavior. Behav Ther 13:529-554
69. Ferrer I, Costell M, Grisolia S (1982) Lesch-Nyhan syndrome like behavior in rats from caffeine injestion. FEBS Lett 141:275-278
70. Findling RL (2005) Pharmacologic treatment of behavioral symptoms in autism and pervasive developmental disorders. J Clin Psychiatry 66(Suppl 10):26-31
71. Finger S, Heavens RP, Sirinathsinghji DJS, Kuehn MR, Dunnett SB (1988) Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome. J Neurol Sci 86:203-213
72. Fontenot MB, Padgett EE III, Dupuy AM, Lynch CR, De Petrillo PB, Higley JD (2005) The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comp Med 55:67-74 (Pubitemid 41557547)
73. Gabriels RL, Agnew JA, Pan Z, Holt KD, Reynolds A, Laudenslager ML (2013) Elevated repetitive behaviors are associated with lower diurnal salivary cortisol levels in autism spectrumdisorder. Biol Psychol 93:262-268
74. Gal E, Dyck MJ, Passmore A (2009) The relationship between stereotyped movements and self-injurious behavior in children with developmental or sensory disabilities. Res Dev Disabil 30:342-352
75. Genovese E, Napoli PA, Bolego-Zonta N (1969) Self-aggressiveness: a new type of behavioural change induced by pemoline. Life Sci 8: 513-515
76. Gluck JP, Sackett GP (1974) Frustration and self-aggression in social isolate rhesus monkeys. J Abn Psychol 83:331-334
77. Gluck JP, Sackett GP (1976) Extinction deficits in socially isolated rhesus monkeys (Macaca mulatta). Dev Psychol 12:173-174
78. Goldstein M, Kuga S, Kusano N, Meller E, Dancis J, Schwartz R (1986) Dopamine agonist induced self-mutilative biting behavior in monkeys with unilateral ventromedial tegmental lesions of the brainstem: possible pharmacological model for Lesch-Nyhan syndrome. Brain Res 367:114-120 (Pubitemid 16011669)
79. Goodall J (1986) The chimpanzees of Gombe: patterns of behavior. Bellknap Press of Harvard University Press, Cambridge
80. Graybiel AM (2008) Habits, rituals, and the evaluative brain. Annu Rev Neurosci 31:359-387
81. Guess D, Carr E (1991) Emergence and maintenance of stereotypy and self-injury. Am J Ment Retard 96:299-319
82. Hanley GP, Iwata BA, McCord BE (2003) Functional analysis of problem behavior: a review. J Appl Behav Anal 36:147-185 (Pubitemid 38613362)
83. Harlow HF, Harlow MK (1962) Social deprivation in monkeys. Scient Am 207:136-146
84. Harlow HF, Dodsworth RO, Harlow MK (1965) Total social isolation in monkeys. Proc Natl Acad Sci U S A 54:90-97
85. Haznedar MM, Buchsbaum MS, Wei TC, Hof PR, Cartwright C, Bienstock CA, Hollander E (2000) Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. Am J Psychiatry 157:1994-2001
86. Haznedar MM, Buchsbaum MS, Hazlett EA, Licalzi EM, Cartwright C, Hollander E (2006) Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders. Am J Psychiatry 163:1252-1263 (Pubitemid 44464455)
87. Herman BH, Hammock MK, Arthur-Smith A, Egan J, Chatoor I, Werner A, Zelnick N (1987) Naltrexone decreases self-injurious behavior. Ann Neurol 22:550-552 (Pubitemid 17164783)
88. Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, Cullinan WE (2003) Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 24:151-180 (Pubitemid 37336539)
89. Hill BK, Bruininks RH (1984)Maladaptive behavior ofmentally retarded individuals in residential facilities. Am J Ment Defic 88:380-387 (Pubitemid 14219066)
90. Hof PR, Knabe R, Bovier P, Bouras C (1991) Neuropathological observations in a case of autism presenting with self-injury behavior. Acta Neuropathol 82:321-326
91. Hollander E, Anagnostou E, Chaplin W, Esposito K, Haznedar MM, Licalzi E, Wasserman S, Soorya L, Buchsbaum M (2005) Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biol Psychiatry 58:226-232 (Pubitemid 41112271)
92. Hollander E, Soorya L, Wasserman S, Esposito K, Chaplin W, Anagnostou E (2006) Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder. Int J Neuropsychopharmacol 9:209-213 (Pubitemid 43255834)
93. Hoshino Y, Ohno Y, Murata S, Yokoyama F, Kaneko M, Kumashiro H (1984) Dexamethasone suppression test in autistic children. Folia Psychiatr Neurol Jpn 38:445-449 (Pubitemid 15149225)
94. Hoshino Y, Yokoyama F, Watanabe M, Murata S, Kaneko M, Kumashiro H (1987) The diurnal variation and response to dexamethasone suppression test of saliva cortisol level in autistic children. Jpn J Psychiatry Neurol 41:227-235 (Pubitemid 17121815)
95. Houpt KA (1983) Self-directed aggression: a stallion behavior problem. Equine Practice 5:6-8
96. Iwata BA, Dorsey MF, Slifer KJ, Bauman KE, Richman GS (1982) Toward a functional analysis of self-injury. Analysis and Intervention in Developmental Disabilities 2:3-20
97. Jacobson JW (1982a) Problem behavior and psychiatric impairment within a developmentally disabled population I: behavior frequency. Appl Res Ment Retard 3:121-139
98. Jacobson JW (1982b) Problem behavior and psychiatric impairment within a developmentally disabled population. II: behavior severity. Appl Res Ment Retard 3:369-381
99. Jenkins JR (2001) Feather picking and self-mutilation in psittacine birds. Vet Clin North Am Exot Anim Pract 4:651-667
100. Jensen JB, Realmuto GM, Garfinkel BD (1985) The dexamethasone suppression test in infantile autism. J Am Acad Child Psychiatry 24:263-265 (Pubitemid 15060476)
101. Jinnah HA, Yitta S, Drew T, Kim BS, Visser JE, Rothstein JD (1999) Calcium channel activation and self-biting in mice. Proc Natl Acad Sci U S A 96:15228-15232 (Pubitemid 30019794)
102. Jones IH, Barraclough BM (1978) Auto-mutilation in animals and its relevance to self-injury in man. Acta Psychiat Scand 58:40-47 (Pubitemid 8397265)
103. Jorgensen MJ, Kinsey JH, Novak MA (1998) Risk factors for self-injurious behavior in captive rhesus monkeys (Macaca mulatta). Am J Primatology 45:187
104. Kahng S, Iwata BA, Lewin A (2002) The impact of functional assessment on the treatment of self-injurious behavior. In: Schroeder SR, Oster-Granite ML, Thompson T (eds) Self-injurious behavior: gene-brainbehavior relationships. American Psychological Association, Washington, DC, pp 119-131
105. Kasim S, Khan Z, Jinnah HA (2002) A new animal model for Lesch-Nyhan syndrome: calcium channel activation with Bay K 8644. In: Schroeder SR, Oster-Granite ML, Thompson T (eds) Self-injurious behavior: gene-brain-behavior relationships. American Psychological Association, Washington, DC, pp 289-298
106. Kaufman J, Plotsky PM, Nemeroff CB, Charney DS (2000) Effects of early adverse experiences on brain structure and function: clinical implications. Biol Psychiatry 48:778-790
107. Keebaugh AC, Sullivan RT, Thomas JW (2007) Gene duplication and inactivation in the HPRT gene family. Genomics 89:134-142 (Pubitemid 44856223)
108. Keebaugh AC, Mitchell HA, Gaval-Cruz M, Freeman KG, Edwards GL, Weinshenker D, Thomas JW (2011) PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. PLoS ONE 6:e22381
109. Kemp AS, Fillmore PT, Lenjavi MR, Lyon M, Chicz-DeMet A, Touchette PE, Sandman CA (2008) Temporal patterns of self-injurious behavior correlate with stress hormone levels in the developmentally disabled. Psychiatry Res 157:181-189 (Pubitemid 350166550)
110. Kemper TL, Bauman ML (1993) The contribution of neuropathologic studies to the understanding of autism. Neurol Clin 11:175-187 (Pubitemid 23063094)
111. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B (2005) The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 62:529-535 (Pubitemid 40628882)
112. Kennedy CH (2002) Evolution of stereotypy into self-injury. In: Schroeder SR, Oster-Granite ML, Thompson T (eds) Self-injurious behavior: gene-brain-behavior relationships. American Psychological Association, Washington, DC, pp 133-143
113. Kies SD, Devine DP (2004) Self-injurious behaviour: a comparison of caffeine and pemoline models in rats. Pharmacol Biochem Behav 79:587-598 (Pubitemid 39600599)
114. Kies SD, Turner CA, Lewis MH, Devine DP (2002) Effects of environmental complexity in an animal model of self-injury. Soc Neurosci Abstr 28:207.8
115. King BH, Au D, Poland RE (1995) Pretreatment with MK-801 inhibits pemoline-induced self-biting behavior in prepubertal rats. Dev Neurosci 17:47-52
116. King BH, Cromwell HC, Lee HT, Behrstock SP, Schmanke T, Maidment NT (1998) Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior. Dev Neurosci 20:180-187 (Pubitemid 28349873)
117. Kuehn MR, Bradley A, Robertson EJ, Evans MJ (1987) A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326:295-298 (Pubitemid 17053753)
118. Kumsta R, Stevens S, Brookes K, Schlotz W, Castle J, Beckett C, Kreppner J, Rutter M, Sonuga-Barke E (2010) 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence fromthe English and Romanian Adoptee (ERA) study. J Child Psychol Psychiatry 51:755-762
119. Langen M, Schnack HG, Nederveen H, Bos D, Lahuis BE, de Jonge MV, van Engeland H, Durston S (2009) Changes in the developmental trajectories of striatum in autism. Biol Psychiatry 66:327-333
120. Lesch M, Nyhan WL (1964) A familial disorder of uric acid metabolism and central nervous system function. Am J Med 36:561-570
121. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531 (Pubitemid 26403928)
122. Lesch KP, Meyer J, Glatz K, Flugge G, Hinney A, Hebebrand J, Klauck SM, Poustka A, Poustka F, Bengel D, Mossner R, Riederer P, Heils A (1997) The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. Rapid communication. J Neural Transm 104: 1259-1266 (Pubitemid 28031819)
123. Lewis MH, Gluck JP, Beauchamp AJ, Keresztury MF, Mailman RB (1990) Long-term effects of early social isolation in Macaca-Mulatta: changes in dopamine receptor function following apomorphine challenge. Brain Res 513:67-73 (Pubitemid 20144273)
124. Lindauer SE, DeLeon IG, Fisher WW (1999) Decreasing signs of negative affect and correlated self-injury in an individual with mental retardation and mood disturbances. J Appl Behav Anal 32:103-106
125. Lopez JF, Akil H, Watson SJ (1999) Neural circuitsmediating stress. Biol Psychiatry 46:1461-1471
126. Lovaas OI (1987) Behavioral treatment and normal educational and intellectual functioning in young autistic children. J Consult Clin Psychol 55:3-9
127. Lutz C, Well A, Novak MA (2003) Stereotypic and self-injurious behavior in rhesus macaques: a survey and retrospective analysis of environment and early experience. Am J Primatol 60:1-15 (Pubitemid 36708161)
128. Marcus RN, Owen R, Kamen L, Manos G, McQuade RD, Carson WH, Aman MG (2009) A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. J Am Acad Child Adolesc Psychiatry 48: 1110-1119
129. Marinovic-Curin J, Marinovic-Terzic I, Bujas-Petkovic Z, Zekan L, Skrabic V, Dogas Z, Terzic J (2008) Slower cortisol response during ACTH stimulation test in autistic children. Eur Child Adolesc Psychiatry 17:39-43 (Pubitemid 351202150)
130. Martin LJ, Spicer DM, Lewis MH, Gluck JP, Cork LC (1991) Social deprivation of infant rhesusmonkeys alters the chemoarchitecture of the brain: I: subcortical regions. J Neurosci 11:3344-3358
131. Matson JL, Nebel-Schwalm M (2007) Assessing challenging behaviors in children with autism spectrum disorders: a review. Res Dev Disabil 28:567-579 (Pubitemid 47539856)
132. Matson JL, Baglio CS, Smiroldo BB, Hamilton M, Paclawskyj TR, Williams D, Kirkpatrick-Sanchez S (1996) Characteristics of autism as assessed by the Diagnostic Assessment for the Severely Handicapped-II (DASH-II). Res Dev Disabil 17:135-143 (Pubitemid 26098492)
133. Matson JL, Sipes M, Fodstad JC, Fitzgerald ME (2011) Issues in the management of challenging behaviours of adults with autism spectrum disorder. CNS Drugs 25:597-606
134. McBride SD, Hemmings A (2005) Altered mesoaccumbens and nigrostriatal dopamine physiology is associated with stereotypy development in a non-rodent species. Behav Brain Res 159:113-118 (Pubitemid 40410592)
135. McClintock K, Hall S, Oliver C (2003) Risk markers associated with challenging behaviours in people with intellectual disabilities: a meta-analytic study. J Intellect Disabil Res 47:405-416 (Pubitemid 37080683)
136. McCracken JT, McGough J, Shah B, Cronin P, Hong D, Aman MG, Arnold LE, Lindsay R, Nash P, Hollway J, McDougle CJ, Posey D, Swiezy N, Kohn A, Scahill L, Martin A, Koenig K, Volkmar F, Carroll D, Lancor A, Tierney E, Ghuman J, Gonzalez NM, Grados M, Vitiello B, Ritz L, Davies M, Robinson J, McMahon D (2002) Research units on pediatric psychopharmacology autism network: risperidone in children with autism and serious behavioral problems. N Engl J Med 347:314-321 (Pubitemid 34815353)
137. McDonnell SM (2008) Practical review of self-mutilation in horses. Anim Reprod Sci 107:219-228
138. McEachin JJ, Smith T, Lovaas OI (1993) Long-termoutcome for children with autismwho received early intensive behavioral treatment. Am J Ment Retard 97:359-372 (Pubitemid 23104584)
139. McElroy SL, Keck PE Jr, Pope HG Jr, Hudson JI (1992) Valproate in the treatment of bipolar disorder: literature review and clinical guidelines. J Clin Psychopharmacol 12:42S-52S
140. Mitchell GD (1968) Persistent behavior pathology in rhesus monkeys following early social isolation. Folia Primatol 8:132-147
141. Mitchell GD, Clark DL (1968) Long-term effects of social isolation in nonsocially adapted Rhesus monkeys. J Genet Psychol 113:117-128
142. Molina VA, Orsingher OA (1981) Effects of Mg-pemoline on the central catecholaminergic system. Arch Int Pharmacodyn Ther 251:66-79 (Pubitemid 11064855)
143. Muehlmann AM, Devine DP (2007) Characterization of drug titers and neurotransmitter concentrations during induction and maintenance of pharmacologically-induced self-injurious behavior. Soc Neurosci Abstr 33:799.20
144. Muehlmann AM, Devine DP (2008) Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour. Behav Brain Res 189:32-40
145. Muehlmann AM, Lewis MH (2012) Abnormal repetitive behaviours: shared phenomenology and pathophysiology. J Intellect Disabil Res 56:427-440
146. Muehlmann AM, Brown BD, Devine DP (2008) Pemoline-induced self-injurious behavior: a rodent model of pharmacotherapeutic efficacy. J Pharmacol Exp Ther 324:214-223 (Pubitemid 350294143)
147. Muehlmann AM, Wilkinson JA, Devine DP (2011) Individual differences in vulnerability for self-injurious behavior: studies using an animal model. Behav Brain Res 217:148-154
148. Muehlmann AM, Edington G, Mihalik AC, Buchwald Z, Koppuzha D, Korah M, Lewis MH (2012a) Further characterization of repetitive behavior in C58 mice: developmental trajectory and effects of environmental enrichment. Behav Brain Res 235:143-149
149. Muehlmann AM, Kies SD, Turner CA, Lewis MH, Devine DP (2012b) Self-injurious behavior: limbic disregulation and stress effects in an animal model. J Intellect Disabil Res 56:490-500
150. Mueller K, Hsiao S (1980) Pemoline-induced self-biting in rats and self-mutilation in the deLange syndrome. Pharmacol Biochem Behav 13:627-631 (Pubitemid 11253882)
151. Mueller K, Nyhan WL (1982) Pharmacologic control of pemoline induced self-injurious behavior in rats. Pharmacol Biochem Behav 16:957-963 (Pubitemid 12081654)
152. Mueller K, Saboda S, Palmour RA, Nyhan WL (1982) Self-injurious behaviour produced in rats by daily caffeine and continuous amphetamine. Pharmacol Biochem Behav 17:613-617 (Pubitemid 13208410)
153. MuellerK, Hollingsworth E, Pettit H (1986) Repeated pemoline produces self-injurious behavior in adult and weanling rats. Pharmacol Biochem Behav 25:933-938 (Pubitemid 17200346)
154. Munafo MR, Brown SM, Hariri AR (2008) Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 63:852-857 (Pubitemid 351458448)
155. Newell KM, Sprague RL, Pain MT, Deutsch KM, Meinhold P (1999) Dynamics of self-injurious behaviors. Am JMent Retard 104:11-21 (Pubitemid 29394902)
156. Newell KM, Challis JH, Boros RL, Bodfish JW (2002) Further evidence on the dynamics of self-injurious behaviors: impact forces and limb motions. Am J
157. Novak MA (2003) Self-injurious behavior in rhesus monkeys: new insights into its etiology, physiology, and treatment. Am J Primatol 59:3-19 (Pubitemid 36280518)
158. Novak MA, Harlow HF (1975) Social recovery of monkeys isolated for the first year of life: 1. Rehabilitation and therapy. Dev Psychol 11: 453-465
159. Novak MA, Suomi SJ (1988) Psychological well-being of primates in captivity. Am Psychol 43:765-773
160. Novak MA, Crockett CM, Sackett GP (2002) Self-injurious behavior in captive macaque monkeys. In: Schroeder SR, Oster-Granite ML, Thompson T (eds) Self-injurious behavior: gene-brain-behavior relationships. American Psychological Association, Washington, DC, pp 151-161
161. Novak MA, Hamel AF, Kelly BJ, Dettmer AM, Meyer JS (2013) Stress, the HPA axis, and nonhuman primate well-being: a review. Appl Anim Behav Sci 143:135-149
162. Nyhan WL (1973) The Lesch-Nyhan syndrome. Ann Rev Med 24:41-60
163. O'Connor TG, Rutter M, Beckett C, Keaveney L, Kreppner JM (2000) The effects of global severe privation on cognitive competence: extension and longitudinal follow-up. English and Romanian Adoptees Study Team. Child Dev 71:376-390
164. Oliver C, Hall S, Murphy G (2005) The early development of self-injurious behaviour: evaluating the role of social reinforcement. J Intellect Disabil Res 49:591-599 (Pubitemid 40990615)
165. Oliver C, Petty J, Ruddick L, Bacarese-Hamilton M (2012) The association between repetitive, self-injurious and aggressive behavior in children with severe intellectual disability. J Autism Dev Disord 42:910-919
166. O'Reilly M, Sigafoos J, Lancioni G, Edrisinha C, Andrews A (2005) An examination of the effects of a classroom activity schedule on levels of self-injury and engagement for a child with severe autism. J Autism Dev Disord 35:305-311 (Pubitemid 41125968)
167. Ornitz EM (1974) The modulation of sensory input and motor output in autistic children. Journal of Autism and Childhood Schizophrenia 4: 197-215
168. Osterling JA, Dawson G, Munson JA (2002) Early recognition of 1-year-old infants with autism spectrum disorder versus mental retardation. Dev Psychopathol 14:239-251 (Pubitemid 351690096)
169. Owen R, Sikich L, Marcus RN, Corey-Lisle P, Manos G, McQuade RD, Carson WH, Findling RL (2009) Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Pediatrics 124:1533-1540
170. Palmen SJ, van Engeland H, Hof PR, Schmitz C (2004) Neuropathological findings in autism. Brain 127:2572-2583 (Pubitemid 39627367)
171. Panerai S, Zingale M, Trubia G, Finocchiaro M, Zuccarello R, Ferri R, Elia M (2009) Special education versus inclusive education: the role of the TEACCH program. J Autism Dev Disord 39:874-882
172. Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472:437-442
173. Peters JM (1967) Caffeine-induced hemorrhagic automutilation. Arch Int Pharmacodyn Ther 169:139-146
174. Potter WZ, Ketter TA (1993) Pharmacological issues in the treatment of bipolar disorder: focus on mood-stabilizing compounds. Can J Psychiatry 38:S51-S56 (Pubitemid 23178020)
175. Powell SB, Newman HA, McDonald TA, Bugenhagen P, Lewis MH (2000) Development of spontaneous stereotyped behavior in deer mice: effects of early and late exposure to a more complex environment. Dev Psychobiol 37:100-108
176. Ratey JJ, Sovner R, Mikkelsen E, Chmielinski HE (1989) Buspirone therapy for maladaptive behavior and anxiety in developmentally disabled persons. J Clin Psychiatry 50:382-384 (Pubitemid 19267919)
177. Reinhardt V, Rossell M (2001) Self-biting in caged macaques: cause, effect, and treatment. J Appl Anim Welf Sci 4:285-294
178. Richards C, Oliver C, Nelson L, Moss J (2012) Self-injurious behaviour in individuals with autism spectrum disorder and intellectual disability. J Intellect Disabil Res 56:476-489
179. Richdale AL, Prior MR (1992) Urinary cortisol circadian rhythm in a group of high-functioning children with autism. J Autism Dev Disord 22:433-447
180. Richman DM, Lindauer SE (2005) Longitudinal assessment of stereotypic, proto-injurious, and self-injurious behavior exhibited by young children with developmental delays. Am J Ment Retard 110:439-450
181. Ricketts RW, Goza AB, Ellis CR, Singh YN, Chambers S, Singh NN, Cooke JC (1994) Clinical effects of buspirone on intractable self-injury in adults with mental retardation. J Am Acad Child Adolesc Psychiatry 33:270-276 (Pubitemid 24047381)
182. Rinaman L, Levitt P, Card JP (2000) Progressive postnatal assembly of limbic-autonomic circuits revealed by central transneuronal transport of pseudorabies virus. J Neurosci 20:2731-2741 (Pubitemid 30220361)
183. Rojahn J (1984) Self-injurious behavior in institutionalized severely/ profoundly retarded adults: prevalence data and staff agreement. J Behav Assessment 6:13-27
184. Rojahn J (1986) Self-injurious and stereotypic behavior of noninstitutionalized mentally retarded people: prevalence and classification. Am J Ment Defic 91:268-276
185. Rojahn J, Esbensen AJ (2002) Epidemiology of self-injurious behavior in mental retardation: a review. In: Schroeder SR, Oster-Granite ML, Thompson T (eds) Self-injurious behavior: gene-brain-behavior relationships. American Psychological Association, Washington, DC, pp 41-77
186. Rubia K, Overmeyer S, Taylor E, Brammer M, Williams SC, Simmons A, Bullmore ET (1999) Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. Am J Psychiatry 156:891-896 (Pubitemid 29260344)
187. Ruedrich S, Swales TP, Fossaceca C, Toliver J, Rutkowski A (1999) Effect of divalproex sodium on aggression and self-injurious behaviour in adults with intellectual disability: a retrospective review. J Intellect Disabil Res 43(Pt 2):105-111 (Pubitemid 29171541)
188. Rutter M (1998) Developmental catch-up, and deficit, following adoption after severe global early privation. English and Romanian Adoptees (ERA) study team. J Child Psychol Psychiatry 39:465-476
189. Rutter M, Andersen-Wood L, Beckett C, Bredenkamp D, Castle J, Groothues C, Kreppner J, Keaveney L, Lord C, O'Connor TG (1999) Quasi-autistic patterns following severe early global privation. English and Romanian Adoptees (ERA) study team. J Child Psychol Psychiatry 40:537-549 (Pubitemid 29213413)
190. Rutter ML, Kreppner JM, O'Connor TG (2001) Specificity and heterogeneity in children's responses to profound institutional privation. Br J Psychiatry 179:97-103 (Pubitemid 32756490)
191. Rutter M, Kreppner J, Croft C, Murin M, Colvert E, Beckett C, Castle J, Sonuga-Barke E (2007) Early adolescent outcomes of institutionally deprived and non-deprived adoptees. III. Quasi-autism. J Child Psychol Psychiatry 48:1200-1207 (Pubitemid 350256549)
192. Ryan BC, Young NB, Crawley JN, Bodfish JW, Moy SS (2010) Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain. Behav Brain Res 208:178-188
193. Sanchez MM, Noble PM, Lyon CK, Plotsky PM, Davis M, Nemeroff CB, Winslow JT (2005) Alterations in diurnal cortisol rhythm and acoustic startle response in nonhuman primates with adverse rearing. Biol Psychiatry 57:373-381 (Pubitemid 40215767)
194. Sandman CA, Barron JL, ColmanH (1990) An orally administered opiate blocker, naltrexone, attenuates self-injurious behavior. Am J Ment Retard 95:93-102 (Pubitemid 20221897)
195. Sandyk R (1985) Naloxone abolishes self-injuring in a mentally retarded child. Ann Neurol 17:520
196. Sansom D, Krishnan VH, Corbett J, Kerr A (1993) Emotional and behavioural aspects of Rett syndrome. Dev Med Child Neurol 35:340-345 (Pubitemid 23101039)
197. Schroeder SR, Mulick JA, Rojahn J (1980) The definition, taxonomy, epidemiology, and ecology of self-injurious behavior. J Autism Dev Disord 10:417-432 (Pubitemid 11170305)
198. Schroeder SR, Oster-Granite ML, Berkson G, Bodfish JW, Breese GR, Cataldo MF, Cook EH, Crnic LS, DeLeon I, Fisher W, Harris JC, Horner RH, Iwata BA, Jinnah HA, King BH, Lauder JM, Lewis MH, Newell K, Nyhan WL, Rojahn J, Sackett GP, Sandman C, Symons F, Tessel RE, Thompson T, Wong DF (2001) Self-injurious behavior: gene-brain-behavior relationships. Ment Retard Dev Disabil Res Rev 7:3-12
199. Schwartz S (2002) Separation anxiety syndrome in cats: 136 cases (1991-2000). J Am Vet Med Assoc 220:1028-1033
200. Schwartz S (2003) Separation anxiety syndrome in dogs and cats. J Am Vet Med Assoc 222:1526-1532
201. Singh NN (1977) Prevalence of self-injury in institutionalised retarded children. N Z Med J 86:325-327
202. Sivam SP (1995) GBR-12909-induced self-injurious behavior: role of dopamine. Brain Res 690:259-263
203. Sivam SP (1996) Dopamine, serotonin and tachykinin in self-injurious behavior. Life Sci 58:2367-2375
204. Smith T, Groen AD, Wynn JW (2000) Randomized trial of intensive early intervention for children with pervasive developmental disorder. Am J Ment Retard 105:269-285 (Pubitemid 30637448)
205. Spratt EG, Nicholas JS, Brady KT, Carpenter LA, Hatcher CR, Meekins KA, Furlanetto RW, Charles JM (2012) Enhanced cortisol response to stress in children in autism. J Autism Dev Disord 42:75-81
206. Stevens SE, Sonuga-Barke EJ, Kreppner JM, Beckett C, Castle J, Colvert E, Groothues C, Hawkins A, Rutter M (2008) Inattention/ overactivity following early severe institutional deprivation: presentation and associations in early adolescence. J Abnorm Child Psychol 36:385-398 (Pubitemid 351421871)
207. Stigler KA, Erickson CA, Mullett JE, Posey DJ, McDougle CJ (2010) Paliperidone for irritability in autistic disorder. J Child Adolesc Psychopharmacol 20:75-78
208. Stigler KA, Mullett JE, Erickson CA, Posey DJ, McDougle CJ (2012) Paliperidone for irritability in adolescents and young adults with autistic disorder. Psychopharmacology (Berl) 223:237-245
209. Suomi SJ, Harlow HF (1972) Social rehabilitation of isolate-reared monkeys. Dev Psychol 6:487-496
210. Symons FJ (2011) Self-injurious behavior in neurodevelopmental disorders: relevance of nociceptive and immune mechanisms. Neurosci Biobehav Rev 35:1266-1274
211. Symons FJ, Clark RD, Hatton DD, Skinner M, Bailey DB Jr (2003) Self-injurious behavior in young boys with fragile X syndrome. Am J Med Genet 118A:115-121 (Pubitemid 37063947)
212. Symons FJ, Thompson A, Rodriguez MC (2004) Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis. Ment Retard Dev Disabil Res Rev 10:193-200 (Pubitemid 40095894)
213. Symons FJ, Harper VN, McGrath PJ, Breau LM, Bodfish JW (2009) Evidence of increased non-verbal behavioral signs of pain in adults with neurodevelopmental disorders and chronic self-injury. Res Dev Disabil 30:521-528
214. Symons FJ, Byiers BJ, Raspa M, Bishop E, Bailey DB (2010a) Self-injurious behavior and fragile X syndrome: findings from the national fragile X survey. Am J Intellect Dev Disabil 115:473-481
215. Symons FJ, Harper V, Shinde SK, Clary J, Bodfish JW (2010b) Evaluating a sham-controlled sensory-testing protocol for nonverbal adults with neurodevelopmental disorders: self-injury and gender effects. J Pain 11:773-781
216. Tiefenbacher S, Novak MA, Jorgensen MJ, Meyer JS (2000) Physiological correlates of self-injurious behavior in captive, socially-reared rhesus monkeys. Psychoneuroendo 25:799-817 (Pubitemid 30670325)
217. Tiefenbacher S, Novak MA, Marinus LM, Chase WK, Miller JA, Meyer JS (2004) Altered hypothalamic-pituitary-adrenocortical function in rhesus monkeys (Macaca mulatta) with self-injurious behavior. Psychoneuroendo 29:501-515 (Pubitemid 38121605)
218. Tinklepaugh OL (1928) The self-mutilation of a male macacus rhesus monkey. Journal of Mammology 9:293-300
219. Tordjman S, Gutknecht L, Carlier M, Spitz E, Antoine C, Slama F, Carsalade V, Cohen DJ, Ferrari P, Roubertoux PL, Anderson GM (2001) Role of the serotonin transporter gene in the behavioral expression of autism. Mol Psychiatry 6:434-439 (Pubitemid 32566094)
220. Turner CA, Lewis MH (2002) Dopaminergic mechanisms in self-injurious behavior and related disorders. In: Schroeder SR, Oster-Granite ML, Thompson T (eds) Self-injurious behavior: gene-brain behavior relationships. American Psychological Association, Washington, DC, pp 165-179
221. Turner CA, Panksepp J, Bekkedal M, Borkowski C, Burgdorf J (1999) Paradoxical effects of serotonin and opioids in pemoline-induced self-injurious behavior. Pharmacol Biochem Behav 63:361-366 (Pubitemid 29287151)
222. Turner CA, Yang MC, Lewis MH (2002) Environmental enrichment: effects on stereotyped behavior and regional neuronal metabolic activity. Brain Res 938:15-21 (Pubitemid 34603105)
223. Turner KC, Frost L, Linsenbardt D, McIlroy JR, Müller RA (2006) Atypically diffuse functional connectivity between caudate nuclei and cerebral cortex in autism. Behav Brain Funct 2:34
224. Vollmer TR (1994) The concept of automatic reinforcement: implications for behavioral research in developmental disabilities. Res Dev Disabil 15:187-207
225. Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peça J, Ding JD, Feliciano C, Chen M, Adams JP, Luo J, Dudek SM, Weinberg RJ, Calakos N, Wetsel WC, Feng G (2007) Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 448:894-900 (Pubitemid 47312780)
226. Whitnall MH (1993) Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system. Prog Neurobiol 40:573-629
227. Willemsen-Swinkels SHN, Buitelaar JK, Nijhof GJ, Van Engeland H (1995) Failure of naltrexone hydrochloride to reduce self-injurious and autistic behavior in mentally retarded adults-double-blind placebo-controlled studies. Arch Gen Psychiatry 52:766-773
228. Wolff JJ, Hazlett HC, Lightbody AA, ReissAL, Piven J (2013) Repetitive and self-injurious behaviors: associations with caudate volume in autism and fragile X syndrome. J Neurodev Disord 5:12
229. Wong-Riley MT (1989) Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci 12:94-101
230. Yatham LN (2003) Efficacy of atypical antipsychotics in mood disorders. J Clin Psychopharmacol 23:S9-14