Role of the serotonin transporter gene in the behavioral expression of autism

Molecular Psychiatry

Volumn 6, Issue 4, 2001, Pages 434-439

  Tordjman, S ^a,b   Gutknecht, L ^a   Carlier, M ^a   Spitz, E ^a   Antoine, C ^b   Slama, F ^a   Carsalade, V ^b   Cohen, D J ^c   Ferrari, P ^b   Roubertoux, P L ^a   Anderson, G M ^c  

^a FRE 2134 CNRS Genetics Neurogenetics and Behavior   (France)

^b Centre Hospitalier Fondation Vallee de Gentilly   (France)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allelic transmission; Autism severity; Extended TDT; HTT promoter polymorphism; Modifying loci; SLC6A4

Indexed keywords

SEROTONIN TRANSPORTER;

ADOLESCENT; ARTICLE; AUTISM; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; FAMILY STUDY; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INTERPERSONAL COMMUNICATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; SOCIAL STATUS;

ADOLESCENT; ADULT; AUTISTIC DISORDER; CARRIER PROTEINS; CHILD; CHILD, PRESCHOOL; CHROMOSOME MAPPING; DNA TRANSPOSABLE ELEMENTS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATHERS; FEMALE; FRANCE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOTHERS; NERVE TISSUE PROTEINS; NUCLEAR FAMILY; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEQUENCE DELETION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; WECHSLER SCALES;

EID: 0034987571     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000873     Document Type: Article

References (41)

1. Autism as a strongly genetic disorder. Evidence of a British twin study
2. Autism and genetics. A decade of research
3. A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden
4. The hyperserotonemia of autism
5. Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retradation
6. Serotonergic responsivity in male young adults with autistic disorder. Results of a pilot study
7. Increased growth hormone response to sumatriptan challenge in adult autistic disorders
8. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder
9. Serotonin regulates mouse cranial neural crest migration
10. Astroglial 5-HT1a receptors and S-100 beta in development and plasticity
11. Medial temporal lobe structures and autism. A review of clinical and experimental findings
12. Primary structure of the human platelet serotonin (5-HT) uptake site: Identity with the brain 5-HT transporter
13. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
14. Vervet monkey (Cercopithecus aethiops sabaeus) whole blood serotonin level is determined by platelet uptake sites
15. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
16. Psychiatric disorders in parents of autistic individuals
17. Plasma beta-endorphin, adrenocorticotropin hormone, and cortisol in autism
18. Evidence of linkage between the serotonin transporter and autistic disorder
19. Serotonin transporter (5-HTT) gene variants associated with autism?
20. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African and European American and Japanese populations and in alcohol dependent subjects
21. The TDT and other family-based tests for linkage disequiliibrium and association
22. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high-density schizophrenia families
23. Serotonin transporter (5-HTT) and δ-aminobutyric acid receptor subunit b3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families
24. A full genome scan for autism with evidence for linkage to a region on chromosome 7q
25. 5-HTTLPR variants not associated with autism spectrum disorders
26. Association analysis of regulatory variation of the serotonin transporter gene with severe alcohol dependence
27. A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics
28. Role of serotonin transporter promotor repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder
29. Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament
30. Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders
31. Pre-Linguistic Autism Diagnostic Observation Schedule (PL/ADOS)
32. Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis
33. Transmission test for linkage disequilbrium: The insulin gene region and Insulin-dependent Diabetes Mellitus (IDDM)
34. A logistic regression extension of the transmission disequilibrium test for continuous traits: Application to linkage disequilbrium between alcoholism and the candidate genes DRD2 and ADH3
35. Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: Extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity
36. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: Heterogeneity owing to diagnostic subtype and severity