Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2

Journal of Neurochemistry

Volumn 128, Issue 5, 2014, Pages 603-616

  Toffolo, Emanuela ^a   Rusconi, Francesco ^a   Paganini, Leda ^a   Tortorici, Marcello ^b   Pilotto, Simona ^b   Heise, Christopher ^c   Verpelli, Chiara ^c,d   Tedeschi, Gabriella ^a,e   Maffioli, Elisa ^a,e   Sala, Carlo ^c,d   Mattevi, Andrea ^b   Battaglioli, Elena ^a,c  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c CNR   (Italy)

^d DEPARTMENT OF NEUROSURGERY   (Italy)

^e Filarete Foundation   (Italy)

Author keywords

corepressor; epigenetics; KDM1A LSD1; neuronal maturation; transcription

Indexed keywords

ASPARTIC ACID; CELL ENZYME; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; ISOENZYME; LSD1 8A; LYSINE SPECIFIC DEMETHYLASE 1; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; EPIGENETICS; EXON; GENE REPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

MAMMALIA;

COREPRESSOR; EPIGENETICS; KDM1A/LSD1; NEURONAL MATURATION; TRANSCRIPTION;

ANIMALS; BRAIN CHEMISTRY; CELLS, CULTURED; CHROMATIN; CO-REPRESSOR PROTEINS; ENZYME REPRESSION; EXONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEMETHYLASES; IMMUNOPRECIPITATION; ISOENZYMES; MASS SPECTROMETRY; MUTAGENESIS, SITE-DIRECTED; NEURITES; PHOSPHORYLATION; PROTEIN CONFORMATION; RATS; TRANSCRIPTION, GENETIC;

EID: 84896696604     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12457     Document Type: Article

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