Protein kinase Cγ (PKCγ): Function of neuron specific isotype

Journal of Biochemistry

Volumn 132, Issue 5, 2002, Pages 683-687

  Saito, Naoaki ^a   Shirai, Yasuhito ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

GABA receptor; Knockout mice; Long term depression; Long term potentiation; Parkinson disease

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CALCIUM ION; DIACYLGLYCEROL; OPIATE RECEPTOR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLSERINE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C GAMMA; UNCLASSIFIED DRUG; ISOENZYME;

BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; ENZYME LOCALIZATION; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MOTOR COORDINATION; NERVE CELL PLASTICITY; NONHUMAN; PARKINSONISM; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PURKINJE CELL; RETINITIS PIGMENTOSA; SHORT SURVEY; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; MOUSE; MOUSE MUTANT; MUTATION; NERVE CELL; PHYSIOLOGY; REVIEW;

PARKINSONIA;

ANIMALS; ISOENZYMES; MICE; MICE, KNOCKOUT; MUTATION; NEURONS; PROTEIN KINASE C;

EID: 0036856263     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003274     Document Type: Short Survey

References (67)

1. Nishizuka, Y. (1988) The molecular heterogeneity of protein kinase C and implications for cellular regulation. Nature 334, 661-665
2. Nishizuka, Y. (1995) Protein kinase C and lipid signaling for sustained cellular response. FASEB J. 9, 484-496
3. Ohno, S. (1997) The distinct biological potential of PKC isotypes in Protein Kinase C, pp. 179-188, Springer-Verlag, Heidelberg
4. Kikkawa, U., Ono, Y., Ogita, K., Fujii, T., Asaoka, Y., Sekiguchi, K., Kosaka, Y., Igarashi, K., and Nishizuka, Y. (1987) Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain. FEBS Lett. 217, 227-231
5. Saito, N., Kikkawa, U., Nishizuka, Y., and Tanaka, C. (1988) Distribution of protein kinase C-like immunoreactive neurons in rat brain. J. Neurosci. 8, 369-382
6. Huang, F.L., Yoshida, Y., Nakabayashi, H., Young, I.W.S., and Huang, K.-P. (1988) Immunocytochemical localization of protein kinase C isozymes in rat brain. J. Neurosci. 8, 4734-4744
7. Tanaka, C. and Saito, N. (1992) Localization of subspecies of protein kinase C in the mammalian central nervous system. Neurochem. Int. 21, 499-512
8. Abeliovich, A., Chen, C., Goda, Y., Silva, A.J., Stevens, C.F., and Tonegawa, S. (1993) Modified hippocampal long-term potentiation in PKCγ-mutant mouse. Cell 75, 1253-1262
9. Abeliovich, A., Paylor, R., Chen, C., Kim, J.J., Wehner, J.M., and Tonegawa, S. (1993) PKCγ mutanat mice exhibit mild deficits in spinal and contextual learning. Cell 75, 1263-1271
10. Parker, P.J., Coussens, L., Totty, N., Rhee, L., Young, S.E., Chen, S., Stabel, M., Waterfield, D., and Ullrich, A. (1986) The complete primary structure of protein kinase C -the major phorbol ester receptor. Science 233, 853-859
11. Coussens, L., Parker, P.J., Rhee, L., Yang-Feng, T.L., Chen, E., Waterfield, M.D., Francke, U., and Ullrich, A. (1986) Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signalling pathways. Science 233, 859-866
12. Kofler, K., Erdel, M., Utermann, G., and Baier, G. (2002) Molecular genetics and structural genomics of the human protein kinase C gene module. Genome Biol. 3, 14.1-14.10
13. Takanaga, H., Mukai, H., Shimakawa, M., Konishi, H., Kikkawa, U., Koizumi, T., and Ono, Y. (1995) Functional characterization of the promoter region of the mouse protein kinase Cγ gene. FEBS Lett. 368, 276-278
14. Nishizuka, Y. (1986) Studies and perspectives of protein kinase C. Science 233, 305-312
15. Cho, W. (2001) Membrane targeting by C1 and C2 domains. J. Biol. Chem. 276, 32407-32410
16. Murakami, K. and Routtenberg, A. (1985) Direct stimulation of purified protein kinase C by unsaturated fatty acids (oleate, arachidonate) in the absence of phospholipids and calcium. FEBS Lett. 192, 189-193
17. Nishizuka, Y. (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9, 484-496
18. Ono, Y., Fujii, T., Igarashi, K., Kuno, T., Tanaka, C., Kikkawa, U., and Nishizuka, Y. (1989) Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence. Proc. Natl. Acad. Sci. USA 86, 4868-4871
19. Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H., Kikkawa, U., Kashiwagi, K., and Saito, N. (2002) Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol. Ther. 93, 271-281
20. Kohout, S.C., Corbalan-Garcia, S., Torrecillas, A., Gomez-Hernandez, J.C., and Falke, J.J. (2002) C2 domains of protein kinase C isoforms alpha, beta, and gamma: Activation parameters and calcium stoichiometries of the membrane-bound state. Biochemistry 41, 11411-11424
21. Bliss, T.V.P. and Collingridge, G.L. (1993) A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361, 31-39
22. Ito, M. (1989) Long term depression. Annu. Rev. Neurosci. 12, 85-102
23. Hashimoto, T., Ase, K., Sawamura, S., Kikkawa, U., Saito, N., Tanaka, C., and Nishizuka, Y. (1988) Postnatal development of a brain specific subspecies of protein kinase C in rat. J. Neurosci. 8, 1678-1683
24. Yoshida, Y., Huang, F.L., Nakabayashi, H., and Huang, K.-P. (1988) Tissue distribution and developmental expression of protein kinase C isozymes. J. Biol. Chem. 263, 9868-9873
25. Kose, A., Saito, N., Ito, H., Kikkawa, U., Nishizuka, Y., and Tanaka, C. (1988) Electron microscopic localization of type I protein kinase C in rat Purkinje cells. J. Neurosci. 8, 4262-4268
26. Kose, A., Ito, A., Saito, N., and Tanaka, C. (1990) Electron microscopic localization of γ- and βII-subspecies of protein kinase C in rat hippocampus. Brain Res. 518, 209-217
27. Sakai, N., Sasaki, K., Ikegaki, N., Shirai, Y., and Saito, N. (1997) Direct visualization of translocation of g-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J. Cell Biol. 139, 1465-1476
28. Oancea, E. and Meyer, T. (1998) Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95, 307-318
29. Shirai, Y., Kashiwagi, K., Yagi, K., Sakai, N., and Saito, N. (1998) Distinct effects of fatty acids on translocation of gamma-and epsilon-subspecies of protein kinase C. J. Cell Biol. 143, 511-521
30. Ohmori, S., Shirai, Y., Sakai, N., Fujii, M., Konishi, H., Kikkawa, U., and Saito, N. (1998) Three distinct mechanisms for translocation and activation of the 6 subspecies of protein kinase C. Mol. Cell. Biol. 18, 5263-5271
31. Linden, D.J., Murakami, K., and Routtenberg, A. (1986) A newly discovered protein kinase C activator (oleic acid) enhances long term potentiation in the intact hippocampus. Brain Res. 379, 358-363
32. Linden, D.J., Sheu, F.-S., Murakami, K., and Routtenberg, A. (1987) Enhancement of long-term potentiation by cis-unsaturated fatty acid: Relation to protein kinase C and phospholipase A2. J. Neurosci. 7, 3783-3792
33. Malenka, R.C., Madison, D.V., and Nicoll, R.A. (1986) Potentiation of synaptic transmission in the hippocampus by phorbol esters. Nature 321, 175-177
34. Hu, G.-Y., Hvalby, O., Walaas, S.I., Albert, K.A., Skjeflo, P., Andersen, P., and Greengard, P. (1987) Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation. Nature 328, 426-429
35. Malinow, R., Schulman, H., and Tsien, R.W. (1989) Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science 245, 862-866
36. Linden, D.J. (1994) Long-term synaptic depression in the mammalian brain. Neuron 12, 457-472
37. Linden, D.J. and Connor, J.A. (1991) Participation of postsynaptic PKC in cerebellar long-term depression in culture. Science 254, 1656-1659
38. Chen, C., Kano, M., Abeliovich, A., Paylor, R., Chen, L., Bao, S., Kim, J.J., Hashimoto, K., Thompson, R.F, and Tonegawa, S. (1995) Impaired motor coordination correlates with Persistent multiple climbing fiber innervation in PKCγ mutanat mice. Cell 83, 1233-1242
39. Hemart, N., Daniel, H., Jaillard, D., and Crepel, F. (1995) Receptors and second messengers involved in long term depression in rat cerebellar slices in vitro: A reappraisal. Eur. J. Neurosci. 7, 45-53
40. Kano, M., Hashimoto, K., Chen, C., Abeliovich, A., Aiba, A., Kurihara, H., Watanabe, M., Inoue, Y., and Tonegawa, S. (1995) Impaired synapse elimination during cerebellar development in PKCγ mutanat mice. Cell 83, 1223-1231
41. Kano, M., Hashimoto, K., Kurihara, H., Watanabe, M., Inoue, Y., Aiba, A., and Tonegawa, S. (1997) Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron 18, 71-79
42. Kano, M., Hashimoto, K., Watanabe, M., Kurihara, H., Offermanns, S., Jiang, H., Wu, Y., Jun, K., Shin, H-S., Inoue, Y., Simon, M.I., and Wu, D. (1998) Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc. Natl. Acad. Sci. USA 95, 15724-15729
43. Narita, M., Makimura, M., Feng, Y.Z., Hoskins, B., and Ho, I.K. (1994) Influence ofchronic morphine treatment on protein kinase C activity: Comparison with butorphanol and implication for opioid torelance. Brain Res. 650, 175-179
44. Narita, M., Narita, M., Mizoguchi, H., and Tseng, L.F. (1995) Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered μ-opioid receptor agonist in the mouse. Eur. J. Pharm. 280, R1-3
45. 5] enkephalin. J. Neurosci. 21, 3715-3720
46. Narita, M., Aoki, T., Ozaki, Y., Yajima, Y., and Suzuki, T. (2001) Involvement of protein kinase Cγ isoform in morphine-induced reinforcing effects. Neuroscience 103, 309-314
47. Martin, W.J., Liu, H., Wang, H., Malmberg, A.B., and Basbaum, A.I. (1999) Inflammation-induced upregulation of protein kinase Cγ immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing. Neuroscience 88, 1267-1274
48. Narita, M., Mizoguchi, H., Suzuki, T., Narita, M., Dun, N.J., Imai, S., Yajima, Y., Nagase, H., Suzuki, T., and Tseng, L.F. (2001) Enhanced μ-opioid responses in the spinal cord of mice lacking protein kinase Cg isoform J. Biol. Chem. 276, 15409- 15414
49. Malmberg, A.B., Chen, C., Tonegawa, S., and Basbaum, A.I. (1997) Preserved acute pain and reduced neuropathis pain in mice lacking PKCγ. Science 278, 279-283
50. Khasar, S.G., Lin, Y-H., Martin, A., Dadgar, J., MaMahon, T., Wang, D., Hundle, B., Aley, K., Isenberg, W., MaCarter, G., Green, P.G., Hodge, C.W., Levine, J.D., and Messing, P.G. (1999) A novel nociceptor signaling pathway revealed in protein kinase Cε mutanat mice. Neuron 24, 253-260
51. 2+, and g-aminobutyrate type A channels. Proc. Natl. Acad. Sci. USA 85, 6192-6196
52. Krishek, B.J., Xie, X., Blackstone, C., Huganir, R.L., Moss, S.J., Smart, T.G. (1994) Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron 12, 1081-1095
53. A receptor whole-cell currents expressed in L929 fibroblasts. Neuron 13, 1421-1431
54. A receptors requires phosphorylation of the alternatively spliced variant of the γ2 subunit. FEBS Lett. 313, 113-117
55. Harris, R.A., McQuilkin, S.J., Paylor, R., Abeliovich, A., Tonegawa, S., and Wehner, J.M. (1995) Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors. Proc. Natl. Acad. Sci. USA 92, 3658-3662
56. Bowers, B.J., Owen, E.H., Collins, A.C., Abeliovich, A., Tonegawa, S., and Wehner, J.M. (1999) Decreased ethanol sensitivity and tolerance development in γ-protein kinase C null mutant mice is dependent on genetic background. Acohol Clin. Exp. Res. 23, 387-397
57. Bowers, B.J. and Wehner, J.M. (2001) Ethanol concumption and behavioral impulsivity are increased in protein kinase Cγ null mutant mice. J. Neurosci. 21, RC180
58. Hodge, C.W., Mehmert, K.K., Kelley, S.P., MaMahon, T., Haywood, A., Olive, M.F., Wang, D., Sanchez-Perez, A.M., and Messing, R.O. (1999) Supersensitivity to allosteric GABAA receptor modulators and alcohol in mice lacking PKCε. Nat. Neurosci. 2, 997-1002
59. Al-Maghtheh, M., Vithana, E.N., Inglehearn, C.F., Moore, T., Bird, A.C., and Bhattacharya, S.S. (1998) Segregation of a PRKCG mutation in two RP11 families. Am. J. Hum. Genet. 62, 1248-1252
60. Osborne, N.N., Barnett, N.D., Moriis, N.J., and Huang, F.L. (1992) The occurrence of three isoenzymes of protein kinase C (α, β, and γ) in retinas of different species. Brain Res. 570, 161-166
61. Newton, A.C. (1997) Regulation of protein kinase C. Curr. Opin. Cell Biol. 9, 161-167
62. Shirai, Y. and Saito, N. (2002) Activation mechanisms of PKC: Maturation, catalytic activation and targeting. J. Biochem. 132, 663-668
63. Campbell, J.M., Payne, A.P., Gilmore, D.P., Russel, D., McGadey, J., Clarke, D.J., Branton, R., Davies, R.W., and Sutclffe, R.G. (1997) Age change in dopamine levels in the corpus striatum of Albino Swiss (AS) and AS/AGU mutant rats. Neurosci. Lett. 239, 54-56
64. Campbell, J.M., Gilmore, D.P., Russel, D., Growney, C.A., Favor, G., Kennedy, A.K., Davies, R.W., Payne, A.P., and Stone, T.W. (2000) Pharmacological analysis of extracellular dopamine and metabolites in the striatum of conscious AS/AGU rats, mutants with locomotor disorder. Neuroscience 100, 45-52
65. Payne, A.P., Campbell, J.M., Russel, D., Favor, G., Sutcliffe, R.G., Bennet, N.K., Davies, R.W., and Stone, T.W. (2000) The AS/AGU rat: A spontaneous model of disruption and degeneration in the nigrostriatal dopaminergic system. J. Anat. 196, 629-633
66. Craig, N.J., Alonso, M.B.D., Hawker, K.L., Shiels, P., Glencorse, T.A., Campbell, J.M., Bennet, N.K., Canham, M., Donald, D., Gardiner, M., Gilmore, D.P., MacDonald, R.J., Maitland, K., MaCallion, A.S., Russel, D., Payne, A.P., Sutcliffe, R.G., and Davies, R.W. (2001) A candidate gene for human neurodegenerative disorders: A rat PKCγ mutation causes a Parkinsonian syndrome. Nat. Neurosci. 4, 1061-1062
67. Shahraki, A. and Stone, T.W. (2002) Long-term potentiation and adenosine sensitivity are unchanged in the AS/AGU protein kinase Cγ-deficient rat. Neurosci. Lett. 327, 165-168