메뉴 건너뛰기




Volumn 18, Issue 2, 2014, Pages 258-268

Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy

Author keywords

[No Author keywords available]

Indexed keywords

3 ALPHA REDUCED NEUROSTEROID; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 5 ALPHA OXIDOREDUCTASE; ANXIOLYTIC AGENT; ETIFOXINE; FINASTERIDE; MEDROXYPROGESTERONE ACETATE; NEUROSTEROID; OXIDOREDUCTASE; TRANSCRIPTION FACTOR FOSB; UNCLASSIFIED DRUG;

EID: 84896693507     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1002/j.1532-2149.2013.00367.x     Document Type: Article
Times cited : (33)

References (47)
  • 1
    • 0036139423 scopus 로고    scopus 로고
    • 2 selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons
    • DOI 10.1038/nn778
    • Ahmadi, S., Lippross, S., Neuhuber, W. L., Zeilhofer, H. U. (2002). PGE (2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci 5, 34-40. (Pubitemid 34038780)
    • (2002) Nature Neuroscience , vol.5 , Issue.1 , pp. 34-40
    • Ahmadi, S.1    Lippross, S.2    Neuhuber, W.L.3    Zeilhofer, H.U.4
  • 3
    • 70449672361 scopus 로고    scopus 로고
    • Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alphareduced neurosteroids
    • Aouad, M., Charlet, A., Rodeau, J. L., Poisbeau, P. (2009). Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alphareduced neurosteroids. Pain 147, 54-59.
    • (2009) Pain , vol.147 , pp. 54-59
    • Aouad, M.1    Charlet, A.2    Rodeau, J.L.3    Poisbeau, P.4
  • 5
    • 21744447595 scopus 로고    scopus 로고
    • A receptor
    • DOI 10.1038/nrn1703
    • Belelli, D., Lambert, J. J. (2005). Neurosteroids: Endogenous regulators of the GABA (A) receptor. Nat Rev Neurosci 6, 565-575. (Pubitemid 40942823)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.7 , pp. 565-575
    • Belelli, D.1    Lambert, J.J.2
  • 6
    • 0015312737 scopus 로고
    • Experimental psychopharmacologic study of a new psychotropic drug, 2-ethylamino-6-chloro-4-methyl-4-phenyl-4H-3, 1-benzoxazine
    • Boissier, J. R., Simon, P., Zaczinska, M., Fichelle, J. (1972). Experimental psychopharmacologic study of a new psychotropic drug, 2-ethylamino-6-chloro-4-methyl-4-phenyl-4H-3, 1-benzoxazine. Therapie 27, 325-338.
    • (1972) Therapie , vol.27 , pp. 325-338
    • Boissier, J.R.1    Simon, P.2    Zaczinska, M.3    Fichelle, J.4
  • 7
    • 53349127737 scopus 로고    scopus 로고
    • Fast nongenomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms
    • Charlet, A., Lasbennes, F., Darbon, P., Poisbeau, P. (2008). Fast nongenomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms. Pain 139, 603-609.
    • (2008) Pain , vol.139 , pp. 603-609
    • Charlet, A.1    Lasbennes, F.2    Darbon, P.3    Poisbeau, P.4
  • 8
    • 0028558684 scopus 로고
    • Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
    • Choi, Y., Yoon, Y. W., Na, H. S., Kim, S. H., Chung, J. M. (1994). Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain 59, 369-376.
    • (1994) Pain , vol.59 , pp. 369-376
    • Choi, Y.1    Yoon, Y.W.2    Na, H.S.3    Kim, S.H.4    Chung, J.M.5
  • 9
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • DOI 10.1038/nature04223, PII NATURE04223
    • Coull, J. A., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., De Koninck, Y. (2005). BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438, 1017-1021. (Pubitemid 43093974)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 1017-1021
    • Coull, J.A.M.1    Beggs, S.2    Boudreau, D.3    Boivin, D.4    Tsuda, M.5    Inoue, K.6    Gravel, C.7    Salter, M.W.8    De Koninck, Y.9
  • 10
    • 0042860080 scopus 로고    scopus 로고
    • Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
    • DOI 10.1038/nature01868
    • Coull, J. A., Boudreau, D., Bachand, K., Prescott, S. A., Nault, F., Sik, A., De Koninck, P., De Koninck, Y. (2003). Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424, 938-942. (Pubitemid 37051684)
    • (2003) Nature , vol.424 , Issue.6951 , pp. 938-942
    • Coull, J.A.M.1    Boudreau, D.2    Bachand, K.3    Prescott, S.A.4    Nault, F.5    Sik, A.6    De Koninck, P.7    De Koninck, Y.8
  • 12
    • 1842786064 scopus 로고    scopus 로고
    • Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
    • DOI 10.1016/j.pain.2004.01.029, PII S0304395904000636
    • Flatters, S. J., Bennett, G. J. (2004). Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain 109, 150-161. (Pubitemid 38479781)
    • (2004) Pain , vol.109 , Issue.1-2 , pp. 150-161
    • Flatters, S.J.L.1    Bennett, G.J.2
  • 13
    • 0028329702 scopus 로고
    • Progesterone metabolites, effective at the GABA(A) receptor complex, attenuate pain sensitivity in rats
    • Frye, C. A., Duncan, J. E. (1994). Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats. Brain Res 643, 194-203. (Pubitemid 24115093)
    • (1994) Brain Research , vol.643 , Issue.1-2 , pp. 194-203
    • Frye, C.A.1    Duncan, J.E.2
  • 16
    • 0037405165 scopus 로고    scopus 로고
    • A receptor pharmacology in adult rats
    • DOI 10.1124/jpet.102.045120
    • Gulinello, M., Smith, S. S. (2003). Anxiogenic effects of neurosteroid exposure: Sex differences and altered GABAA receptor pharmacology in adult rats. J Pharmacol Exp Ther 305, 541-548. (Pubitemid 36459168)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.305 , Issue.2 , pp. 541-548
    • Gulinello, M.1    Smith, S.S.2
  • 17
    • 0037628261 scopus 로고    scopus 로고
    • A receptors are mediated by the β subunit
    • DOI 10.1016/S0028-3908(03)00187-4
    • Hamon, A., Morel, A., Hue, B., Verleye, M., Gillardin, J. M. (2003). The modulatory effects of the anxiolytic etifoxine on GABA (A) receptors are mediated by the beta subunit. Neuropharmacology 45, 293-303. (Pubitemid 36836126)
    • (2003) Neuropharmacology , vol.45 , Issue.3 , pp. 293-303
    • Hamon, A.1    Morel, A.2    Hue, B.3    Verleye, M.4    Gillardin, J.-M.5
  • 19
    • 68049107195 scopus 로고    scopus 로고
    • Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis
    • Hernstadt, H., Wang, S., Lim, G., Mao, J. (2009). Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis. Brain Res 1286, 42-52.
    • (2009) Brain Res , vol.1286 , pp. 42-52
    • Hernstadt, H.1    Wang, S.2    Lim, G.3    Mao, J.4
  • 20
    • 3843143811 scopus 로고    scopus 로고
    • Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons
    • DOI 10.1111/j.1460-9568.2004.03530.x
    • Karchewski, L. A., Bloechlinger, S., Woolf, C. J. (2004). Axonal injurydependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons. Eur J Neurosci 20, 671-683. (Pubitemid 39043647)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.3 , pp. 671-683
    • Karchewski, L.A.1    Bloechlinger, S.2    Woolf, C.J.3
  • 21
    • 0742287913 scopus 로고    scopus 로고
    • A Miniature IPSCs in Lamina II of the Spinal Cord
    • DOI 10.1523/JNEUROSCI.4642-03.2004
    • Keller, A. F., Breton, J. D., Schlichter, R., Poisbeau, P. (2004). Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA (A) miniature IPSCs in lamina II of the spinal cord. J Neurosci 24, 907-915. (Pubitemid 38146601)
    • (2004) Journal of Neuroscience , vol.24 , Issue.4 , pp. 907-915
    • Keller, A.F.1    Breton, J.-D.2    Schlichter, R.3    Poisbeau, P.4
  • 24
    • 9744268957 scopus 로고    scopus 로고
    • ΔfosB: A molecular switch for long-term adaptation in the brain
    • DOI 10.1016/j.molbrainres.2004.05.014, PII S0169328X04002281, Neurogenomics
    • McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., Nestler, E. J. (2004). DeltaFosB: A molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res 132, 146-154. (Pubitemid 39586757)
    • (2004) Molecular Brain Research , vol.132 , Issue.2 , pp. 146-154
    • McClung, C.A.1    Ulery, P.G.2    Perrotti, L.I.3    Zachariou, V.4    Berton, O.5    Nestler, E.J.6
  • 25
    • 40849126968 scopus 로고    scopus 로고
    • The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury
    • DOI 10.1016/j.nbd.2007.12.001, PII S0969996107002689
    • Meyer, L., Venard, C., Schaeffer, V., Patte-Mensah, C., Mensah-Nyagan, A. G. (2008). The biological activity of 3alpha-hydroxysteroid oxidoreductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury. Neurobiol Dis 30, 30-41. (Pubitemid 351391981)
    • (2008) Neurobiology of Disease , vol.30 , Issue.1 , pp. 30-41
    • Meyer, L.1    Venard, C.2    Schaeffer, V.3    Patte-Mensah, C.4    Mensah-Nyagan, A.G.5
  • 26
    • 0034831641 scopus 로고    scopus 로고
    • A double blind parallel group placebo controlled comparison of sedative and amnesic effects of etifoxine and lorazepam in healthy subjects
    • DOI 10.1046/j.1472-8206.2001.00025.x
    • Micallef, J., Soubrouillard, C., Guet, F., Le Guern, M. E., Alquier, C., Bruguerolle, B., Blin, O. (2001). A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects. Fundam Clin Pharmacol 15, 209-216. (Pubitemid 32868687)
    • (2001) Fundamental and Clinical Pharmacology , vol.15 , Issue.3 , pp. 209-216
    • Micallef, J.1    Soubrouillard, C.2    Guet, F.3    Le Guern, M.E.4    Alquier, C.5    Bruguerolle, B.6    Blin, O.7
  • 27
    • 24944591879 scopus 로고    scopus 로고
    • Role of the peripheral benzodiazepine receptor in sensory neuron regeneration
    • DOI 10.1016/j.mcn.2005.07.010, PII S1044743105001570
    • Mills, C. D., Bitler, J. L., Woolf, C. J. (2005). Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mol Cell Neurosci 30, 228-237. (Pubitemid 41316565)
    • (2005) Molecular and Cellular Neuroscience , vol.30 , Issue.2 , pp. 228-237
    • Mills, C.D.1    Bitler, J.L.2    Woolf, C.J.3
  • 28
    • 0030032724 scopus 로고    scopus 로고
    • Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: Ultrastructural morphometric analysis of axonal alterations
    • DOI 10.1016/0304-3959(95)00077-1
    • Mosconi, T., Kruger, L. (1996). Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: Ultrastructural morphometric analysis of axonal alterations. Pain 64, 37-57. (Pubitemid 26062245)
    • (1996) Pain , vol.64 , Issue.1 , pp. 37-57
    • Mosconi, T.1    Kruger, L.2
  • 29
    • 33646377162 scopus 로고    scopus 로고
    • Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disroders with anxiety: A double-blind controlled study in general practice
    • DOI 10.1002/hup.757
    • Nguyen, N., Fakra, E., Pradel, V., Jouve, E., Alquier, C., Le Guern, M. E., Micallef, J., Blin, O. (2006). Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: A double-blind controlled study in general practice. Hum Psychopharmacol 21, 139-149. (Pubitemid 43670663)
    • (2006) Human Psychopharmacology , vol.21 , Issue.3 , pp. 139-149
    • Nguyen, N.1    Fakra, E.2    Pradel, V.3    Jouve, E.4    Alquier, C.5    Le Guern, M.-E.6    Micallef, J.7    Blin, O.8
  • 30
    • 20144373040 scopus 로고    scopus 로고
    • A channels are responsible for the potent peripheral analgesic effects of 5α-reduced neuroactive steroids
    • DOI 10.1016/j.pain.2005.01.009
    • Pathirathna, S., Brimelow, B. C., Jagodic, M. M., Krishnan, K., Jiang, X., Zorumski, C. F., Mennerick, S., Covey, D. F., Todorovic, S. M., Jevtovic-Todorovic, V. (2005). New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain 114, 429-443. (Pubitemid 40385881)
    • (2005) Pain , vol.114 , Issue.3 , pp. 429-443
    • Pathirathna, S.1    Brimelow, B.C.2    Jagodic, M.M.3    Krishnan, K.4    Jiang, X.5    Zorumski, C.F.6    Mennerick, S.7    Covey, D.F.8    Todorovic, S.M.9    Jevtovic-Todorovic, V.10
  • 31
    • 4644271455 scopus 로고    scopus 로고
    • Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks
    • DOI 10.1007/s00018-004-4235-4
    • Patte-Mensah, C., Li, S., Mensah-Nyagan, A. G. (2004). Impact of neuropathic pain on the gene expression and activity of cytochrome P450 side-chain-cleavage in sensory neural networks. Cell Mol Life Sci 61, 2274-2284. (Pubitemid 39280124)
    • (2004) Cellular and Molecular Life Sciences , vol.61 , Issue.17 , pp. 2274-2284
    • Patte-Mensah, C.1    Li, S.2    Mensah-Nyagan, A.G.3
  • 32
    • 77955589267 scopus 로고    scopus 로고
    • Selective regulation of 3 alpha-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: A possible mechanism to cope with peripheral nerve injury-induced chronic pain
    • Patte-Mensah, C., Meyer, L., Schaeffer, V., Mensah-Nyagan, A. G. (2010). Selective regulation of 3 alpha-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: A possible mechanism to cope with peripheral nerve injury-induced chronic pain. Pain 150, 522-534.
    • (2010) Pain , vol.150 , pp. 522-534
    • Patte-Mensah, C.1    Meyer, L.2    Schaeffer, V.3    Mensah-Nyagan, A.G.4
  • 33
    • 0022403301 scopus 로고
    • Purification and properties of 3α-hydroxysteroid dehydrogenase from rat brain cytosol: Inhibition by nonsteroidal anti-inflammatory drugs and progestins
    • Penning, T. M., Sharp, R. B., Krieger, N. R. (1985). Purification and properties of 3 alpha-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins. J Biol Chem 260, 15266-15272. (Pubitemid 16147972)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.28 , pp. 15266-15272
    • Penning, T.M.1    Sharp, R.B.2    Krieger, N.R.3
  • 34
    • 0032848244 scopus 로고    scopus 로고
    • Nerve constriction in the rat: Model of neuropathic, surgical and central pain
    • DOI 10.1016/S0304-3959(99)00085-8, PII S0304395999000858
    • Pitcher, G. M., Ritchie, J., Henry, J. L. (1999). Nerve constriction in the rat: Model of neuropathic, surgical and central pain. Pain 83, 37-46. (Pubitemid 29446155)
    • (1999) Pain , vol.83 , Issue.1 , pp. 37-46
    • Pitcher, G.M.1    Ritchie, J.2    Henry, J.L.3
  • 37
    • 33646862809 scopus 로고    scopus 로고
    • Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways
    • Schlichter, R., Keller, A. F., De Roo, M., Breton, J. D., Inquimbert, P., Poisbeau, P. (2006). Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways. J Mol Neurosci 28, 33-51.
    • (2006) J Mol Neurosci , vol.28 , pp. 33-51
    • Schlichter, R.1    Keller, A.F.2    De Roo, M.3    Breton, J.D.4    Inquimbert, P.5    Poisbeau, P.6
  • 38
    • 0034078118 scopus 로고    scopus 로고
    • Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine
    • DOI 10.1016/S0028-3908(99)00253-1, PII S0028390899002531
    • Schlichter, R., Rybalchenko, V., Poisbeau, P., Verleye, M., Gillardin, J. (2000). Modulation of GABAergic synaptic transmission by the nonbenzodiazepine anxiolytic etifoxine. Neuropharmacology 39, 1523-1535. (Pubitemid 30330869)
    • (2000) Neuropharmacology , vol.39 , Issue.9 , pp. 1523-1535
    • Schlichter, R.1    Rybalchenko, V.2    Poisbeau, P.3    Verleye, M.4    Gillardin, J.-M.5
  • 39
    • 0036829011 scopus 로고    scopus 로고
    • Can we conquer pain?
    • DOI 10.1038/nn942
    • Scholz, J., Woolf, C. J. (2002). Can we conquer pain? Nat Neurosci 5(Suppl), 1062-1067. (Pubitemid 35247200)
    • (2002) Nature Neuroscience , vol.5 , Issue.SUPPL. , pp. 1062-1067
    • Scholz, J.1    Woolf, C.J.2
  • 40
    • 0032433519 scopus 로고    scopus 로고
    • Treatment of adjustment disorder with anxiety: Efficacy and tolerance of etifoxine in a double-blind controlled study
    • Servant, D., Graziani, P. L., Moyse, D., Parquet, P. J. (1998). Treatment of adjustment disorder with anxiety: Efficacy and tolerance of etifoxine in a double-blind controlled study. Encephale 24, 569-574.
    • (1998) Encephale , vol.24 , pp. 569-574
    • Servant, D.1    Graziani, P.L.2    Moyse, D.3    Parquet, P.J.4
  • 41
    • 0032527128 scopus 로고    scopus 로고
    • Withdrawal from 3α-OH-5α-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABA(A)-gated current and increases the GABA(A) receptor α4 subunit in association with increased anxiety
    • Smith, S. S., Gong, Q. H., Li, X., Moran, M. H., Bitran, D., Frye, C. A., Hsu, F. C. (1998). Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety. J Neurosci 18, 5275-5284. (Pubitemid 28311944)
    • (1998) Journal of Neuroscience , vol.18 , Issue.14 , pp. 5275-5284
    • Smith, S.S.1    Gong, Q.H.2    Li, X.3    Moran, M.H.4    Bitran, D.5    Frye, C.A.6    Hsu, F.-C.7
  • 42
    • 0025689849 scopus 로고
    • The clinical development of a 5 alpha-reductase inhibitor, finasteride
    • Stoner, E. (1990). The clinical development of a 5 alpha-reductase inhibitor, finasteride. J Steroid Biochem Mol Biol 37, 375-378.
    • (1990) J Steroid Biochem Mol Biol , vol.37 , pp. 375-378
    • Stoner, E.1
  • 43
    • 36349004814 scopus 로고    scopus 로고
    • Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
    • DOI 10.1016/j.brainres.2007.09.041, PII S0006899307022329
    • Ugale, R. R., Sharma, A. N., Kokare, D. M., Hirani, K., Subhedar, N. K., Chopde, C. T. (2007). Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats. Brain Res 1184, 193-201. (Pubitemid 350160573)
    • (2007) Brain Research , vol.1184 , Issue.1 , pp. 193-201
    • Ugale, R.R.1    Sharma, A.N.2    Kokare, D.M.3    Hirani, K.4    Subhedar, N.K.5    Chopde, C.T.6
  • 44
    • 31844436767 scopus 로고    scopus 로고
    • The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain
    • DOI 10.1016/j.pbb.2005.11.013, PII S0091305705003734
    • Verleye, M., Akwa, Y., Liere, P., Ladurelle, N., Pianos, A., Eychenne, B., Schumacher, M., Gillardin, J. M. (2005). The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain. Pharmacol Biochem Behav 82, 712-720. (Pubitemid 43184049)
    • (2005) Pharmacology Biochemistry and Behavior , vol.82 , Issue.4 , pp. 712-720
    • Verleye, M.1    Akwa, Y.2    Liere, P.3    Ladurelle, N.4    Pianos, A.5    Eychenne, B.6    Schumacher, M.7    Gillardin, J.-M.8
  • 45
    • 79955671902 scopus 로고    scopus 로고
    • Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: Any relation to overexpression of central GABAA receptor beta2 subunits?
    • Verleye, M., Dumas, S., Heulard, I., Krafft, N., Gillardin, J. M. (2010). Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: Any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol 21, 457-470.
    • (2010) Eur Neuropsychopharmacol , vol.21 , pp. 457-470
    • Verleye, M.1    Dumas, S.2    Heulard, I.3    Krafft, N.4    Gillardin, J.M.5
  • 46
    • 4644254282 scopus 로고    scopus 로고
    • Effects of etifoxine on stress-induced hyperthermia, freezing behavior and colonic motor activation in rats
    • DOI 10.1016/j.physbeh.2004.07.010, PII S0031938404003130
    • Verleye, M., Gillardin, J. M. (2004). Effects of etifoxine on stress-induced hyperthermia, freezing behavior and colonic motor activation in rats. Physiol Behav 82, 891-897. (Pubitemid 39297086)
    • (2004) Physiology and Behavior , vol.82 , Issue.5 , pp. 891-897
    • Verleye, M.1    Gillardin, J.-M.2
  • 47
    • 0345096619 scopus 로고    scopus 로고
    • Effects of stress and etifoxine on pentobarbital-induced loss of righting reflex in Balb/cByJ and C57BL/6J mice
    • DOI 10.1016/j.neulet.2003.09.010
    • Verleye, M., Heulard, I., Nuss, P., Gillardin, J. M. (2003). Effects of stress and etifoxine on pentobarbital-induced loss of righting reflex in Balb/cByJ and C57BL/6J mice. Neurosci Lett 353, 127-130. (Pubitemid 37510197)
    • (2003) Neuroscience Letters , vol.353 , Issue.2 , pp. 127-130
    • Verleye, M.1    Heulard, I.2    Nuss, P.3    Gillardin, J.-M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.