Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms

Pain

Volumn 139, Issue 3, 2008, Pages 603-609

  Charlet, Alexandre ^a   Lasbennes, François ^a   Darbon, Pascal ^a   Poisbeau, Pierrick ^a  

^a Hopitaux Universitaires de Strasbourg   (France)

Author keywords

Allopregnanolone; Carrageenan; GABAA receptor; Glycine receptor; Inflammatory pain; Mechanical allodynia; Neurosteroid; Progesterone; Spinal cord; Spinal inhibition; Thermal heat hyperalgesia

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA HYDROXY 5BETA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; CARRAGEENAN; ELTANOLONE; GLYCINE; NEUROSTEROID; PROGESTERONE; STRYCHNINE;

ALLODYNIA; ALLOSTERISM; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; DRUG SAFETY; HEAT HYPERALGESIA; HYPERALGESIA; MALE; MECHANICAL STIMULATION; METABOLITE; NOCICEPTION; NONHUMAN; PAIN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL PAIN; STEREOISOMERISM; STEROIDOGENESIS; THERMAL STIMULATION;

ALLOSTERIC REGULATION; ANALGESICS, NON-NARCOTIC; ANIMALS; BICUCULLINE; CARRAGEENAN; DRUG EVALUATION, PRECLINICAL; HOT TEMPERATURE; HYPERALGESIA; INFLAMMATION; MALE; MOLECULAR CONFORMATION; PAIN THRESHOLD; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, GLYCINE; SPINAL CORD; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; STRYCHNINE; TOUCH;

EID: 53349127737     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2008.06.016     Document Type: Article

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