Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats

Molecular Pain

Volumn 6, Issue , 2010, Pages

  Aloisi, Anna M ^a,c   Ceccarelli, Ilaria ^a   Fiorenzani, Paolo ^a   Maddalena, Melinda ^a   Rossi, Alessandra ^a,d   Tomei, Valentina ^a,d   Sorda, Giuseppina ^b   Danielli, Barbara ^b   Rovini, Michele ^a   Cappelli, Andrea ^a   Anzini, Maurizio ^a   Giordano, Antonio ^a,d  

^a UNIVERSITY OF SIENA   (Italy)

^b Ospedale 21   (Italy)

^c IRCCS   (Italy)

^d TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; FORMALDEHYDE; MESSENGER RNA; MORPHINE; STEROID 5ALPHA REDUCTASE 1; TESTOSTERONE; CHOLESTENONE 5ALPHA REDUCTASE;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN TISSUE; CONTROLLED STUDY; DIENCEPHALON; DRUG BLOOD LEVEL; DRUG EFFICACY; EXPERIMENTAL TEST; FORMALIN TEST; GENE EXPRESSION REGULATION; GENOMICS; LIVER PARENCHYMA; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; TESTIS; TESTOSTERONE BLOOD LEVEL; ANIMAL; ANTIBODY SPECIFICITY; BLOOD; BRAIN; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; AROMATASE; BEHAVIOR, ANIMAL; BRAIN; CHOLESTENONE 5 ALPHA-REDUCTASE; FORMALDEHYDE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MORPHINE; ORGAN SPECIFICITY; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TESTOSTERONE;

EID: 77958145469     PISSN: 17448069     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-8069-6-69     Document Type: Article

References (44)

1. Abs R, Verhelst J, Maeyaert J, Van Buyten JP, Opsomer F, Adriaensen H, Verlooy J, Van Havenbergh T, Smet M, Van Acker K. Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab 2000, 85:2215-2222. 10.1210/jc.85.6.2215, 10852454.
2. Daniell HW. DHEAS deficiency during consumption of sustained-action prescribed opioids: evidence for opioid-induced inhibition of adrenal androgen production. J Pain 2006, 7:901-907. 10.1016/j.jpain.2006.04.011, 17157776.
3. Aloisi AM, Aurilio C, Bachiocco V, Biasi G, Fiorenzani P, Pace MC, Paci V, Pari G, Passavanti G, Ravaioli L, Sindaco G, Vellucci R, Ceccarelli I. Endocrine consequences of opioid therapy. Psychoneuroendocrinology 2009, 34:S162-8. 10.1016/j.psyneuen.2009.05.013, 19540049.
4. Aloisi AM, Pari G, Ceccarelli I, Vecchi I, Ietta F, Lodi L, Paulesu L. Gender-related effects of chronic non-malignant pain and opioid therapy on plasma levels of macrophage migration inhibitory factor (MIF). Pain 2005, 115:142-51. 10.1016/j.pain.2005.02.019, 15836977.
5. Kalra PS, Sahu A, Kalra SP. Opiate-induced hypersensitivity to testosterone feedback: pituitary involvement. Endocrinology 1988, 122:997-1003. 10.1210/endo-122-3-997, 3277841.
6. Ceccarelli I, Rossi A, Maddalena M, Weber E, Aloisi AM. Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrazole. J Cell Physiol 2009, 221:1-4. 10.1002/jcp.21830, 19492405.
7. Amini H, Ahmadiani A. In vivo evidence for an increase in 5alpha-reductase activity in the rat central nervous system following morphine exposure. Int J Dev Neurosci 2005, 23:621-6. 10.1016/j.ijdevneu.2005.07.001, 16143488.
8. Amini H, Ahmadiani A. Increase in testosterone metabolism in rat central nervous system by formalin-induced tonic pain. Pharmacology, Biochemistry and Behavior 2002, 74:199-204.
9. Piva F, Limonta P, Dondi D, Pimpinelli F, Martini L, Maggi R. Effects of steroids on the brain opioid system. J Steroid Biochem Mol Biol 1995, 53:343-8. 10.1016/0960-0760(95)00072-8, 7626478.
10. Kicman AT. Biochemical and physiological aspects of endogenous androgens. Hand Exp Pharmacol 2010, 195:25-64.
11. Zheng P. Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Prog Neurobiol 2009, 89:134-52. 10.1016/j.pneurobio.2009.07.001, 19595736.
12. Gerdes LC, Sonnendeker EWW, Polakow ES. Physiological change affected by estrogen-progesterone and clonidine treatment in climateric women. Am J Obstet Gynecol 1982, 142:98-104.
13. Luine VN, Richards ST, Wu VY, Beck KD. Estradiol enhances learning and memory in a spatial memory task and affects levels of monoaminergic neurotransmitters. Horm Behav 1998, 34:149-62. 10.1006/hbeh.1998.1473, 9799625.
14. Naftolin F. Brain aromatization of androgens. J Reprod Med 1994, 39:257-61.
15. Basbaum AI, Fields HL. Endogenous pain control mechanisms: review and hypothesis. Ann Neurol 1978, 4:451-62. 10.1002/ana.410040511, 216303.
16. Janson W, Stain C. Peripheral opioid analgesia. Curr Pharm Biotechnol 2003, 4:270-4. 10.2174/1389201033489766, 14529429.
17. Ceccarelli I, De Padova AM, Fiorenzani P, Massafra C, Aloisi AM. Single opioid administration modifies gonadal steroids in both the CNS and plasma of male rats. Neuroscience 2006, 140:929-37. 10.1016/j.neuroscience.2006.02.044, 16580783.
18. Białek M, Zaremba P, Borowicz KK, Czuczwar SJ. Neuroprotective role of testosterone in the nervous system. Pol J Pharmacol 2004, 56:509-18.
19. Lanlua P, Decorti F, Gangula PR, Chung K, Taglialatela G, Yallampalli C. Female steroid hormones modulate receptors for nerve growth factor in rat dorsal root ganglia. Biol Reprod 2001, 64:331-8. 10.1095/biolreprod64.1.331, 11133691.
20. Woolley CS, Schwartzkroin PA. Hormonal effects on the brain. Epilepsia 1998, 39:S2-8. 10.1111/j.1528-1157.1998.tb02601.x, 9915614.
21. Foy MR, Xu J, Xie X, Brinton RD, Thompson RF, Berger TW. 17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. J Neurophysiol 1999, 81:925-9.
22. Rudick CN, Woolley CS. Estradiol induces a phasic Fos response in the hippocampal CA1 and CA3 regions of adult female rats. Hippocampus 2000, 10:274-83. 10.1002/1098-1063(2000)10:3<274::AID-HIPO8>3.0.CO;2-Q, 10902897.
23. Toran-Allerand CD, Singh M, Sétáló G. Novel mechanisms of estrogen action in the brain: new players in an old story. Front Neuroendocrinol 1999, 20:97-121. 10.1006/frne.1999.0177, 10328986.
24. Goodenough S, Schleusner D, Pietrzik C, Skutella T, Behl C. Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes. Neuroscience 2005, 132:581-9. 10.1016/j.neuroscience.2004.12.029, 15837120.
25. Shayu D, Rao AJ. Expression of functional aromatase in the epididymis: role of androgens and LH in modulation of expression and activity. Mol Cell Endocrinol 2006, 249:40-50.
26. Carreau S, Silandre D, Bois C, Bouraima H, Galeraud-Denis I, Delalande C. Estrogens: a new player in spermatogenesis. Folia Histochem Cytobiol 2007, 45:S5-10.
27. Vree TB, Verwey-van Wissen CP. Pharmacokinetics and metabolism of codeine in humans. Biopharm Drug Dispos 1992, 13:445-60. 10.1002/bdd.2510130607, 1391681.
28. Spritzer MD, Galea LA. Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats. Dev Neurobiol 2007, 67:1321-33. 10.1002/dneu.20457, 17638384.
29. Goldstein LA, Sengelaub DR. Differential effects of dihydrotestosterone and estrogen on the development of motoneuron morphology in a sexually dimorphic rat spinal nucleus. J Neurobiol 1994, 25:878-92. 10.1002/neu.480250711, 8089663.
30. Beyer C, Hutchison JB. Androgens stimulate the morphological maturation of embryonic hypothalamic aromatase-immunoreactive neurons in the mouse. Brain Res Dev Brain Res 1997, 98:74-81. 10.1016/S0165-3806(96)00170-8, 9027406.
31. Grino PB, Griffin JE, Wilson JD. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology 1990, 126:1165-72. 10.1210/endo-126-2-1165, 2298157.
32. Cherrier MM. Testosterone effects on cognition in health and disease. Front Horm Res 2009, 37:150-62. full_text, 19011295.
33. Parducz A, Hajszan T, Maclusky NJ, Hoyk Z, Csakvari E, Kurunczi A, Prange-Kiel J, Leranth C. Synaptic remodeling induced by gonadal hormones: neuronal plasticity as a mediator of neuroendocrine and behavioral responses to steroids. Neuroscience 2006, 138:977-85. 10.1016/j.neuroscience.2005.07.008, 16310961.
34. Negri-Cesi P, Colciago A, Motta M, Martini L, Celotti F. Aromatase expression and activity in male and female cultured rat hypothalamic neurons: effect of androgens. Mol Cell Endocrinol 2001, 178:1-10. 10.1016/S0303-7207(01)00442-7, 11403888.
35. Agarwal VR, Takayama K, Van Wyk JJ, Simpson ER, Bulun SE. Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma. J Clin Endocrinol Metab 1998, 83:1797-1800. 10.1210/jc.83.5.1797, 9589695.
36. Barney ML, Patil JG, Gunasekera RM, Carter CG. Distinct cytochrome P450 aromatase isoforms in the common carp (Cyprinus carpio): sexual dimorphism and onset of ontogenic expression. Gen Comp Endocrinol 2008, 156:499-508. 10.1016/j.ygcen.2008.03.013, 18430424.
37. Jin Y, Penning TM. Steroid 5α-reductase and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. Best Pract Res Clin Endocrinol Metab 2001, 15:79-94. 10.1053/beem.2001.0120, 11469812.
38. Nagypál A, Wood RI. Region-specific mechanisms for testosterone-induced Fos in hamster brain. Brain Res 2007, 1141:197-204. 10.1016/j.brainres.2007.01.022, 1857344, 17276422.
39. Frye CA. Hormonal influences on seizures: basic neurobiology. Int Rev Neurobiol 2008, 83:27-77. 10.1016/S0074-7742(08)00003-2, 18929075.
40. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-10. 10.1016/0304-3959(83)90201-4, 6877845.
41. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(t)) method. Methods 2001, 25:402-8. 10.1006/meth.2001.1262, 11846609.
42. Abraham GE, Manlimos FS, Solis M, Wickman AC. Combined radioimmunoassay of four steroids in one ml of plasma: II. Androgens. Clin Biochem 1975, 8:374-8. 10.1016/S0009-9120(75)93886-2, 1204212.
43. Mauget R, Jouventin P, Lacroix Ashji S. Plasma LH and steroid hormones in King penguin (Aptenodytes patagonicus) during the onset of the breeding cycle. Comp Endocrinol 1994, 93:36-43.
44. Gil AG, Silvan G, Illera M, Illera JC. The effects of anesthesia on the clinical chemistry of New Zealand White rabbits. Comtemp Top Lab Anim Sci 2004, 43:25-9.