Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism

Chinese Medicine

Volumn 7, Issue , 2012, Pages

  Song, Ju Xian ^a   Choi, Mandy Y Man ^a   Wong, Kavin C Kit ^a   Chung, Winkie W Yan ^a   Sze, Stephen C Wing ^a   Ng, Tzi Bun ^b   Zhang, Kalin Y Bo ^a  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

BAICALEIN; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ROTENONE;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; DRUG ANTAGONISM; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; PARKINSONISM; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 84856011723     PISSN: None     EISSN: 17498546     Source Type: Journal    
DOI: 10.1186/1749-8546-7-1     Document Type: Article

References (34)

1. Schapira AH, Bezard E, Brotchie J, Calon F, Collingridge GL, Ferger B, Hengerer B, Hirsch E, Jenner P, Le Novere N, Obeso JA, Schwarzschild MA, Spampinato U, Davidai G. Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov 2006, 5:845-854. 10.1038/nrd2087, 17016425.
2. Cannon JR, Greenamyre JT. Neurotoxic in vivo models of Parkinson's disease recent advances. Prog Brain Res 2010, 184:17-33.
3. Beal MF. Experimental models of Parkinson's disease. Nat Rev Neurosci 2001, 2:325-334.
4. Fox SH, Brotchie JM. The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future. Prog Brain Res 2010, 184:133-157.
5. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 2000, 3:1301-1306. 10.1038/81834, 11100151.
6. Watabe M, Nakaki T. Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther 2007, 323:499-507. 10.1124/jpet.107.127597, 17726156.
7. Greenamyre JT, Cannon JR, Drolet R, Mastroberardino PG. Lessons from the rotenone model of Parkinson's disease. Trends Pharmacol Sci 2010, 31:141-142. 10.1016/j.tips.2009.12.006, 2846992, 20096940.
8. Manyam BV, Sanchez-Ramos JR. Traditional and complementary therapies in Parkinson's disease. Adv Neurol 1999, 80:565-574.
9. Li Q, Zhao D, Bezard E. Traditional Chinese medicine for Parkinson's disease: a review of Chinese literature. Behav Pharmacol 2006, 17:403-410. 10.1097/00008877-200609000-00006, 16940761.
10. Lebeau A, Esclaire F, Rostene W, Pelaprat D. Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity. Neuroreport 2001, 12:2199-2202. 10.1097/00001756-200107200-00031, 11447334.
11. Wang SY, Wang HH, Chi CW, Chen CF, Liao JF. Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice. Eur J Pharmacol 2004, 506:55-61. 10.1016/j.ejphar.2004.10.029, 15588624.
12. Cui L, Zhang X, Yang R, Liu L, Wang L, Li M, Du W. Baicalein is neuroprotective in rat MCAO model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacol Biochem Behav 2010, 96:469-475. 10.1016/j.pbb.2010.07.007, 20637223.
13. Liu C, Wu J, Xu K, Cai F, Gu J, Ma L, Chen J. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem 2010, 112:1500-1512. 10.1111/j.1471-4159.2009.06561.x, 20050973.
14. Xue X, Qu XJ, Yang Y, Sheng XH, Cheng F, Jiang EN, Wang JH, Bu W, Liu ZP. Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor kappaB p65 activation. Biochem Biophys Res Commun 2010, 403:398-404. 10.1016/j.bbrc.2010.11.042, 21093411.
15. Zhang Z, Wu R, Li P, Liu F, Zhang W, Zhang P, Wang Y. Baicalin administration is effective in positive regulation of twenty-four ischemia/reperfusion-related proteins identified by a proteomic study. Neurochem Int 2009, 54:488-496. 10.1016/j.neuint.2009.02.005, 19428793.
16. Jiang M, Porat-Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, Li Q, Gillardon F, Hengerer B, Berlinicke C, Smith WW, Zack DJ, Poirier MA, Ross CA, Duan W. Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism. J Neurochem 2010, 114:419-429. 10.1111/j.1471-4159.2010.06752.x, 2910156, 20412383.
17. Lee HJ, Noh YH, Lee DY, Kim YS, Kim KY, Chung YH, Lee WB, Kim SS. Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Eur J Cell Biol 2005, 84:897-905. 10.1016/j.ejcb.2005.07.003, 16323286.
18. Mu X, He G, Cheng Y, Li X, Xu B, Du G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Pharmacol Biochem Behav 2009, 92:642-648. 10.1016/j.pbb.2009.03.008, 19327378.
19. Mu X, He GR, Yuan X, Li XX, Du GH. Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice. Pharmacol Biochem Behav 2011, 98:286-291. 10.1016/j.pbb.2011.01.011, 21262257.
20. Im HI, Joo WS, Nam E, Lee ES, Hwang YJ, Kim YS. Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice. J Pharmacol Sci 2005, 98:185-189. 10.1254/jphs.SC0050014, 15942123.
21. Song JX, Shaw PC, Sze CW, Tong Y, Yao XS, Ng TB, Zhang YB. Chrysotoxine, a novel bibenzyl compound, inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-kappaB modulation. Neurochem Int 2010, 57:676-689. 10.1016/j.neuint.2010.08.007, 20708055.
22. Cheng Y, He G, Mu X, Zhang T, Li X, Hu J, Xu B, Du G. Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett 2008, 441:16-20. 10.1016/j.neulet.2008.05.116, 18586394.
23. Hu LF, Lu M, Wu ZY, Wong PT, Bian JS. Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function. Mol Pharmacol 2009, 75:27-34. 10.1124/mol.108.047985, 18832435.
24. Sai Y, Chen J, Wu Q, Liu H, Zhao J, Dong Z. Phosphorylated-ERK 1/2 and neuronal degeneration induced by rotenone in the hippocampus neurons. Environ Toxicol Pharmacol 2009, 27:366-372. 10.1016/j.etap.2008.12.004, 21783966.
25. Chen X, Zhang N, Zou HY. Protective effect of baicalin on mouse with Parkinson's disease induced by MPTP. Zhongguo Zhong Xi Yi Jie He Za Zhi 2007, 27:1010-1012.
26. Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I. Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction. Exp Mol Med 2010, 42:811-822. 10.3858/emm.2010.42.12.084, 3015155, 20959717.
27. Radad K, Rausch WD, Gille G. Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration. Neurochem Int 2006, 49:379-386. 10.1016/j.neuint.2006.02.003, 16580092.
28. Testa CM, Sherer TB, Greenamyre JT. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res Mol Brain Res 2005, 134:109-118.
29. Zhang S, Ye J, Dong G. Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. J Mol Neurosci 2009, 40:311-320.
30. Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003, 39:615-647. 10.1016/S0161-5890(02)00252-3, 12493639.
31. Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM. Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem 1996, 271:4573-4576. 10.1074/jbc.271.9.4573, 8617712.
32. Gomez-Santos C, Ferrer I, Reiriz J, Vinals F, Barrachina M, Ambrosio S. MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. Brain Res 2002, 935:32-39. 10.1016/S0006-8993(02)02422-8, 12062470.
33. Kulich SM, Horbinski C, Patel M, Chu CT. 6-Hydroxydopamine induces mitochondrial ERK activation. Free Radic Biol Med 2007, 43:372-383. 10.1016/j.freeradbiomed.2007.04.028, 2023873, 17602953.
34. Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 2007, 170:75-86. 10.2353/ajpath.2007.060524, 1762689, 17200184.