Flavonoid baicalein modulates H2O2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells

Cellular and Molecular Neurobiology

Volumn 32, Issue 4, 2012, Pages 549-560

  Moslehi, Maryam ^a   Meshkini, Azadeh ^a   Yazdanparast, Razieh ^a  

^a UNIVERSITY OF TEHRAN   (Iran)

Author keywords

GCS; Baicalein; Mitogen activated protein kinases; Neurodegenerative disease; Oxidative stress; SK N MC cells

Indexed keywords

BAICALEIN; CASPASE 9; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL DEATH; CELL LEVEL; CELL VIABILITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PEROXIDATION;

ANTIOXIDANTS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; FLAVANONES; FLAVONOIDS; HUMANS; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; NERVE DEGENERATION; NEUROBLASTOMA; OXIDANTS;

EID: 84864702091     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9795-x     Document Type: Article

References (53)

1. Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW (2002) Three dimensional structure of the apoptosome: implications for assembly, pro-caspase-9 binding and activation. J Mol Cell 9:423-432
2. Aebi H (1984) Catalase in vitro. Method Enzymol 105:121-126
3. Ardestani A, Yazdanparast R, Nejad AS (2008) 2-Deoxy-D-ribose-induced oxidative stress causes apoptosis in human monocytic cells. Toxicol In Vitro 22:968-979
4. Atmani D, Chaher N, Berboucha M, Debbache N, Boudaoud H (2009) Flavonoids in human health: from structure to biological activity. J Curr Nutr Food Sci 5:225-237
5. Barrett WC, DeGnores JP, Keng YF, Zhang ZY, Yim MB, Chock PB (1999) Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein tyrosine phospha-tase 1B. J Biol Chem (JBC) 27:34543-34546
6. Burdo J, Schubert D, Maher P (2008) Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. J Brain Res 1189:12-22
7. Chen Ch, Raung Sh, Liao S, Chen Sh (2004) Inhibition of inducible nitric oxide synthetase expression by baicalein in endotoxin/cytokine-stimulated microglia. J Biochem Pharmacol 67:957-965
8. Chen YC, Chow J, Lin C, Wu C, Shen S (2006) Baicalein inhibition of oxidative stress-induced apoptosis via modulation of ERK activation and induction of HO-1 gene expression in rat glioma cells C6. J Toxicol Appl Pharmacol 216:263-273
9. Cheng Y, He G, Mu X, Zhang T, Li X, Hu J (2008) Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. J Neurosci Lett 441:16-20
10. Chipuk JE, Green DR (2008) How do Bcl-2 proteins induce mitochondrial outer membrane permeabilization? J Trends Cell Biol 18:157-164
11. Choi JH, Choi AY, Yoon H, Choe W, Yoon K, Ha J, Yeo E, Kang I (2010) Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction. J Exp Mol Med 42:811-822
12. Cos P, Ying L, Calomme M, Hu JP, Cimanga K, Poel CV, Pieters L, Vlietinck AJ, Berghe DV (1998) Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J Nat Prod 61:71-76
13. Cowan KJ, Storey KB (2003) Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol 206:1115-1170
14. Cullinan SB, Diehl JA (2006) Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int J Biochem Cell Biol 38:317-332
15. Davis RJ (1999) Signal transduction by the c-Jun N-terminal kinase. J Biochem Soc Symp 64:1-12
16. Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. J Cell 103:239-252
17. Drapper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Method Enzymol 186:421-431
18. Earnshaw WC, Kaufmann M (1999) Mammalian caspases: structure, activation, substrate and functions during apoptosis. J Annu Rev Biochem 68:383-424
19. Ellman GL (1959) Tissue sulfhydryl groups. J Arch Biochem Biophys 82:70-77
20. Gao D, Tawa R, Masaki H, Okano Y, Sakurai H (1998) Protective effects of baicalein against cell damage by reactive oxygen species. J Chem Pharm Bull 46:1383-1387
21. Hodnick WF, Kung FF, Roettger WJ, Bohmont CW, Pardini RS (1986) Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids: a structure-activity study. J Biochem Pharmacol 35:2345-2357
22. Hodnick WF, Milosavlijevic EB, Nelson JH, Pardini RS (1998) Electrochemistry of flavonoids: relationships between redox potentials, inhibition of mitochondrial respiration, and production of oxygen radicals by flavonoids. J Biochem Pharmacol 37:2607-2611
23. Ishige K, Schubert D, Sagara Y (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. J Free Radic Biol Med 30:433-446
24. Jensen K (2003) Oxidative stress and free radicals. J Mol Struct 666:387-392
25. Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. J Biochim Biophys Acta (BBA) 1802:396-405
26. LeBel CP, Ischiropoulos H, Bondy SC (1992) Evaluation of the probe 2', 7'-dichlorofluoresceinasanindicatorofreactive oxygen species formation and oxidative stress. J Chem Res Toxicol 5:227-231
27. Lin H, Juan Sh, Shen Sh, Hsu F, Chen Y (2003) Inhibition of lipopolysaccharide-induced nitric oxide production by flavo-noids in RAW264.7 macrophages involves heme oxygenase-1. J Biochem Pharmacol 66:1821-1832
28. Lin H, Shen Sh, Lin Ch, Yang L, Chen Y (2007) Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. J Biochim Biophys Acta (BBA) 1773:1073-1086
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
30. Markovic ZS, Markovic JM, Milenkovic D, Filipovic N (2011) Structural and electronic features of baicalein and its radicals. J Monatsh Chem 142:145-152
31. Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1-15
32. Michaelis ML (2003) Drug targeting Alzheimer's disease: some things old and some things new. J Pharmacol Exp Ther 304:897-904
33. Mielke K, Herdegen T (2000) JNK and p38 stress kinases-degener-ative effectors of signal transduction-cascades in the nervous system. J Prog Neurobiol 61:45-60
34. Miura YH, Tomita I, Watanabe T, Hirayama T, Fukui S (1998) Active oxygens generation by flavonoids. J Biol Pharm Bull 21:93-96
35. 2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells by EUK134, a salen derivative. J Basic Clin Pharmacol Toxicol 108:378-384
36. Osburn WO, Kensler W (2008) Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. J Mut Res 659:31-39
37. Park HS, Park E, Kim MS, Ahn K, Kim IY, Choi EJ (2000) Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism. J Biol Chem (JBC) 275:2527-2531
38. Pratico D (2008) Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy. J Ann NY Acad Sci 1147:70-78
39. Reznick AZ, Packer L (1994) Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Method Enzymol 233:357-363
40. Rossi L, Mazzitelli S, Arciello M, Capo CR, Rotilio G (2008) Benefits from dietary polyphenols for brain aging and Alzheimer's disease. J Neurochem Res 33:2390-2400
41. Schroeter H, Boyd C, Spencer JPE, Williams RJ, Cadenas E, Rise-Evans C (2002) MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. J Neurobiol Aging 23:861-880
42. Schuler M, Green DR (2001) Mechanism of p53-dependent apoptosis. J Biochem Soc Trans 29:684-688
43. Shen HM, Liu Z (2006) JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. J Free Radical Biol Med 40:928-939
44. Shen YH, Godlewski J, Zhu J, Sathyanarayana P, Learner V, Birrer MJ, Rana A, Tzivion G (2003) Crosstalk between JNK/SAPK and ERK/MAPK pathway. J Biol Chem (JBC) 278:26715-26721
45. Shen G, Hebber V, Nair S, Xu C, Li W, Lin W, Keum YS, Han J, Gallo MA, Kong AN (2004) Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem (JBC) 279:23052-23060
46. Sorg O (2004) Oxidative stress: a theoretical model or a biological reality? C R Biol 327:649-662
47. Spencer JPE (2007) The interactions of flavonoids within neuronal signaling pathways. J Genes Nutr 2:257-273
48. Spencer JPE (2008) Flavonoids: modulators of brain function? Br J Nutr 99:ES60-ES77
49. Suk K, Lee H, Kang SS, Cho GJ, Choi WS (2003) Flavonoid baicalein attenuates activation-induced cell death of brain microglia. J Pharmacol Exp Ther 305:638-646
50. Sun X, Erb H, Murphy TH (2005) Coordinate regulation of glutathione metabolism in astrocytes by Nrf2. J Biochem Res Commun 236:371-377
51. Townsend DM, Tew KD, Tapiero H (2003) The importance of glutathione in human disease. J Biomed Pharm 57:145-155
52. Zhang Sh, Ye J, Dong G (2010) Neuroprotective effect of baicalein on hydrogen peroxide mediated oxidative stress and mitochon-drial dysfunction in PC12 cells. J Mol Neurosci 40:311-320
53. Zhu X, Raina AK, Lee H, Casadesus G, Smith MA, Perry G (2004) Oxidative stress signaling in Alzheimer's disease. J Brain Res 1000:32-39