The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis

Journal of Neuroimmune Pharmacology

Volumn 9, Issue 2, 2014, Pages 245-258

  Xu, Daping ^a   Duan, Hongwei ^b   Zhang, Zaijun ^a,b,c   Cui, Wei ^c   Wang, Liang ^a,b   Sun, Yewei ^b   Lang, Ming ^b   Hoi, Pui Man ^a   Han, Yifan ^c   Wang, Yuqiang ^b   Lee, Simon MingYuen ^a,d  

^a China jack1987168 163com   (Macao)

^b JINAN UNIVERSITY   (China)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^d University of Macau   (Macao)

Author keywords

Dopaminergic neuron; Mitochondrial dependent apoptosis; MPTP; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 2,5 [[(1,1 DIMETHYLETHYL)OXIDOIMINO]METHYL] 3,6 TRIMETHYLPYRAZINE; CASPASE; CASPASE 3; CASPASE 9; CYTOCHROME C; DOPAMINE; GLUTATHIONE; MALONALDEHYDE; MESSENGER RNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NEUROTOXIN; NITRONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; REACTIVE OXYGEN METABOLITE; SELEGILINE; SUPEROXIDE DISMUTASE; TETRAMETHYLPYRAZINE; TN 2; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT; PYRAZINE DERIVATIVE; SCAVENGER;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; CYTOPLASM; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; GENE EXPRESSION; GRANULAR CELL; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA; ANIMAL; C57BL MOUSE; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTOXICATION; NERVE CELL; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FREE RADICAL SCAVENGERS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MPTP POISONING; NEURONS; NEUROPROTECTIVE AGENTS; PYRAZINES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84896543098     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-013-9514-0     Document Type: Article

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