Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts

Experimental Cell Research

Volumn 323, Issue 1, 2014, Pages 189-197

  Mao, Shuai ^a,b,c,d   Wang, Yanting ^a   Zhang, Minzhou ^c,d   Hinek, Aleksander ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^d GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

Collagen; Elastin; Estrogen receptors; Human cardiac fibroblasts; Tanshinone IIA

Indexed keywords

COLLAGEN TYPE 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ELASTIN; ELASTIN BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR 30; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; PHYTOESTROGEN; PROTEIN LYSINE 6 OXIDASE; TANSHINONE IIA; TROPOCOLLAGEN; TROPOELASTIN; UNCLASSIFIED DRUG;

ARTICLE; DOWN REGULATION; ENZYME SYNTHESIS; FIBROBLAST; GENE EXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

COLLAGEN; ELASTIN; ESTROGEN RECEPTORS; HUMAN CARDIAC FIBROBLASTS; TANSHINONE IIA;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; COLLAGEN TYPE I; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DITERPENES, ABIETANE; DOWN-REGULATION; ELASTIC TISSUE; ELASTIN; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; PHYTOESTROGENS; PROTEIN BINDING; PROTEIN-LYSINE 6-OXIDASE; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; TROPOELASTIN; UP-REGULATION;

EID: 84896464420     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.02.001     Document Type: Article

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