Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin

Journal of Investigative Dermatology

Volumn 130, Issue 10, 2010, Pages 2396-2406

  Mitts, Thomas F ^a,b   Bunda, Severa ^c,d   Wang, Yanting ^a,b,c,d   Hinek, Aleksander ^c,d  

^a Human Matrix Sciences LLC   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; COLLAGEN TYPE 1; ELASTIN; EPLERENONE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; SOMATOMEDIN C; SPIRONOLACTONE; MESSENGER RNA; SOMATOMEDIN C RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ELASTIC FIBER; ELASTICITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; KELOID; PRIORITY JOURNAL; SCAR; SKIN FIBROBLAST; UPREGULATION; ADULT; ANALOGS AND DERIVATIVES; BIOPSY; CICATRIX; CYTOLOGY; DRUG EFFECTS; FEMALE; FIBROBLAST; GENE EXPRESSION; GENETICS; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; SKIN;

ADULT; ALDOSTERONE; BIOPSY; CELLS, CULTURED; CICATRIX; COLLAGEN TYPE I; ELASTICITY; ELASTIN; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; GENE EXPRESSION; HUMANS; KELOID; MINERALOCORTICOID RECEPTOR ANTAGONISTS; ORGAN CULTURE TECHNIQUES; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; SKIN; SPIRONOLACTONE; UP-REGULATION;

EID: 77956883402     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.155     Document Type: Article

References (76)

1. Amadeu TP, Braune AS, Porto LC et al. (2004) Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids. Wound Repair Regen 12:169-174
2. Bayat A, Arscott G, Ollier WE et al. (2005) Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg 58:28-37
3. Boney C, Gruppuso PA, Faris RA et al. (2000) The critical role of Shc in insulin like growth factor-1 mediated mitogenesis and differentiation in 3T3-L1 preadipocytes. Mol Endocrinol 14:805-813
4. Bristow J, Carey W, Egging D et al. (2005) Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome. Am J Med Genet C Semin Med Genet 139C:24-30
5. Bunda S, Kaviani N, Hinek A (2005) Fluctuations of intracellular iron modulate elastin production. J Biol Chem 280:2341-2351
6. Bunda S, Liu P, Wang Y et al. (2007) Aldosterone induces elastin production in cardiac fibroblasts through activation of IGF-1 receptor in MR-independent manner. Am J Pathol 171:809-819
7. Bunda S, Wang Y, Mitts TF et al. (2009) Aldosterone stimulates elastogenesis in cardiac fibroblasts via MR-independent action involving the consecutive activation of Ga13, c-Src, the IGF-I receptor, and PI3 kinase/ Akt. J Biol Chem 284:16633-16647
8. Catala-Pétavy C, Machet L, Georgesco G et al. (2009) Contribution of skin biometrology to the diagnosis of the Ehlers-Danlos syndrome in a prospective series of 41 patients. Skin Res Technol 15:412-417
9. Chai W, Garrelds IM, de Vries R et al. (2005) Nongenomic effects of aldosterone in the human heart: interaction with angiotensin II. Hypertension 46:701-706
10. Chernosky ME, Knox JM (1964) Atrophic striae after occlusive corticosteroid therapy. Arch Dermatol 90:15-19
11. Chetty A, Cao GJ, Nielsen HC (2006) Insulin-like growth factor-I signaling mechanisms, type I collagen and alpha smooth muscle action in human fetal lung fibroblasts. Pediatr Res 60:389-394
12. Connell JM, Davies E (2005) The new biology of aldosterone. J Endocrinol 186:1-20
13. Daian T, Ohtsuru A, Rogounovitch T et al. (2003) Insulin-like growth factor-I enhances transforming growth factor-beta-induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts. J Invest Dermatol 120:956-962
14. De Chalain T, Phillips JH, Hinek A (1999) Bioengineering of elastic cartilage with aggregated porcine and human auricular chondrocytes and hydrogels containing alginate, collagen, and kappa-elastin. J Biomed Mater Res 44:280-288
15. Dupont J, Holzenberger M (2003) Biology of insulin-like growth factors in development. Birth Defects Res C Embryo Today 69:257-271
16. Edmondson SR, Thumiger SP, Werther GA et al. (2003) Epidermal home-ostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr Rev 24:737-764
17. El-Domyati M, Attia S, Saleh F et al. (2002) Intrinsic aging versus photoaging: a comparative histopathological, immunohistochemical, and ultrastruc-tural study of skin. Exp Dermatol 11:398-405
18. Fisher GJ, Kang S, Varani J et al. (2002) Mechanisms of photoaging and chronological skin aging. Arch Dermatol 138:1462-1470
19. Garvey W, Fathi A, Bigelow F et al. (1986) Improved Movat pentachrome stain. Stain Technol 61:60-62
20. Ghahary A, Shen YJ, Wang R et al. (1998) Expression and localization of insulin-like growth factor-1 in normal and post-burn hypertrophic scar tissue in human. Mol Cell Biochem 183:1-9
21. Guinot C, Malvy DJ, Ambroisine L et al. (2002) Relative contribution of intrinsic versus extrinsic factors to skin aging as determined by a validated skin age score. Arch Dermatol 138:1454-1460
22. Hinek A, Jain S, Taylor G et al. (2008) Mechanistic links between high copper levels and increased elastolysis that contribute to clinical phenotype of patient with cutis marmorata telangiectasia congenita. Am J Hum Gen 19:2520-2527
23. Hinek A, Smith AC, Cutiongco EM et al. (2000) Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kd elastin-binding protein. Am J Hum Genet 66:859-872
24. Hinek A, Wilson SE (2000) Impaired elastogenesis in hurler disease: Dermatan sulfate accumulation linked to deficiency in elastin-binding protein and elastic fiber assembly. Am J Pathol 156:925-938
25. Hinek A, Wong Y, Liu K et al. (2005) Proteolytic digest from bovine ligamentum nuchae stimulate deposition of new elastin-enriched matrix in cultures and transplants of human dermal fibroblasts. J Dermatol Sci 39:3135-3140
26. Hueber F, Schaefer H, Wepierre J (1994) Role of transepidermal and transfollicular routes in percutaneous absorption of steroids: in vitro studies on human skin. Skin Pharmacol 7:237-244
27. Imokawa G (2008) Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibroblast-derived elastase. Arch Dermatol Res 300:S7-20
28. Jalali M, Bayat A (2007) Current use of steroids in management of abnormal raised skin scars. Surgeon 5:175-180
29. Jansen PM, Danser AH, Imholz BP et al. (2009) Aldosterone-receptor antagonism in hypertension. J Hypertens 27:680-691
30. Jensen DE, Rich CB, Terpstra AJ et al. (1995) Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1binding. Evidence for the role of Rb in mediating Sp1 binding in aortic smooth muscle cells. J Biol Chem 270:6555-6563
31. Jeschke MG, Schubert T, Klein D (2004) Exogenous liposomal IGF-I cDNA gene transfer leads to endogenous cellular and physiological responses in an acute wound. Am J Physiol Regul Integr Comp Physiol 286:R958-66
32. Jiang XY, Gao GD, Du XJ et al. (2007) The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts. Acta Cardiol 62:429-438
33. Jimenez F, Mitts TF, Liu K et al. (2006) Ellagic and tannic acids protect newly synthesized elastic fibers from premature enzymatic degradation in dermal fibroblast cultures. J Investig Dermatol 126:1272-1280
34. Jyung RW, Mustoe JA, Busby WH et al. (1994) Increased wound breaking strength induced by insulin-like growth factor I in combination with insulin-like growth factor binding protein-1. Surgery 115:233-239
35. Kenouch S, Lombes M, Delahaye F et al. (1994) Human skin as target for aldosterone: coexpression of mineralocorticoid receptors and 11-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab 79:1334-1341
36. Kielty CM, Sherratt MJ, Shuttleworth CA (2002) Elastic fibres. J Cell Sci 115:2817-2828
37. Krug AW, Schuster C, Gassner B et al. (2002) Human epidermal growth factor receptor-1 expression renders Chinese hamster ovary cells sensitive to alternative aldosterone signaling. J Biol Chem 277:45892-45897
38. Krutmann J (2003) Premature skin aging by ultraviolet radiation and other environmental hazards. The molecular basis. Hautarzt 54:809-817
39. Lai L, Chen J, Hao CM et al. (2006) Aldosterone promotes fibronectin production through a Smad2-dependent TGF-beta1 pathway in mesan-gial cells. Biochem Biophys Res Commun 348:70-75
40. Lee KS, Rho YJ, Jang SI et al. (1994) Decreased expression of collagen and fibronectin genes in striae distensae tissue. Clin Exp Dermatol 19:285-288
41. LeRoith D, Werner H, Beitner-Johnson D et al. (1995) Molecular and cellular aspects of the insulin-like growth factor-I receptor. Endocr Rev 16:143-163
42. Lewis KG, Bercovitch L, Dill SW et al. (2004) Acquired disorders of elastic tissue: part I. Increased elastic tissue and solar elastotic syndromes. J Am Acad Dermatol 51:1-21
43. Lijnen P, Petrov V (2000) Induction of cardiac fibrosis by aldosterone. J Mol Cell Cardiol 32:865-879
44. Lösel R, Schultz A, Boldyreff B et al. (2004) Rapid effects of aldosterone on vascular cells: clinical implications. Steroids 69:575-578
45. Magnusson BM, Cross SE, Winckle G et al. (2006) Percutaneous absorption of steroids: determination of in vitro permeability and tissue reservoir characteristics in human skin layers. Skin Pharmacol Physiol 19:336-342
46. Mahoney MG, Brennan D, Starcher B et al. (2009) Extracellular matrix in cutaneous ageing: the effects of 0.1% copper-zinc malonate-containing cream on elastin biosynthesis. Exp Dermatol 18:205-211
47. Mihailidou AS, Funder JW (2005) Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular system. Steroids 70:347-351
48. Mitts TF, Jimenez F, Hinek A (2005) Skin-biopsy analysis reveals predisposition to stretch mark formation. Aesth Surg J 25:593-600
49. Musto L (1996) Modified Movat pentachrome stain. J Histotechnol 9:173-174
50. Nagai Y, Miyata K, Sun GP et al. (2005) Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts. Hypertension 46:1039-1045
51. Ohtani T, Furukawa F (2002) Pseudoxanthoma elasticum. J Dermatol 29:615-620
52. Patroi I, Annessi G, Girolomoni G (2003) Mid-dermal elastolysis: a clinical, histologic, and immunohistochemical study of 11 patients. J Am Acad Dermatol 48:846-851
53. Peterson JE, Kulik G, Jelinek T et al. (1996) Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src. J Biol Chem 271:31562-31571
54. Pieraggi MT, Julian M, Delmas M et al. (1982) Striae: Morphological aspects of connective tissue. Virchows Arch A Pathol Anat Histol 396: 279-289
55. Raine-Fenning NJ, Brincat MP, Muscat-Baron Y (2003) Skin aging and menopause: implications for treatment. Am J Clin Dermatol 4:371-378
56. Rickard AJ, Funder JW, Fuller PJ et al. (2006) The role of the glucocorticoid receptor in mineralocorticoid/salt-mediated cardiac fibrosis. Endocrinology 147:5901-5906
57. Ritz-Timme S, Laumeier I, Collins MJ (2003) Aspartic acid racemization: evidence for marked longevity of elastin in human skin. Br J Dermatol 149:951-959
58. Roberts MS, Cross SE, Anissimov YG (2004) Factors affecting the formation of a skin reservoir for topically applied solutes. Skin Pharmacol Physiol 17:3-16
59. Roques C, Téot L (2008) The use of corticosteroids to treat keloids: a review. Int J Low Extrem Wounds 7:137-145
60. Sainte Marie Y, Toulon A, Paus R et al. (2007) Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Am J Pathol 171:846-860
61. Slemp AE, Kirschner RE (2006) Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr 18:396-402
62. Son ED, Lee JY, Lee S et al. (2005) Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo. J Invest Dermatol 124:1149
63. Summers VK, Sheehan HL, Hipkin LJ et al. (1964) Differential diagnosis of Cushing's syndrome and obesity associated with striae. Lancet 13:1079-1082
64. Uitto J, Bernstein EF (1998) Molecular mechanisms of cutaneous aging: connective tissue alterations in the dermis. J Investig Dermatol Symp Proc 1:41-44
65. Uitto J, Chu M-L, Gallo R et al. (2008) Collagen, elastic fibers, and the extracellular matrix of the dermis. In: Fitzpatrick's Dermatology in General Medicine. (Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, eds), New York: McGraw-Hill, 517-542
66. Uitto J, Ringpfeil F (2007) Heritable diseases affecting the elastic tissues: cutis laxa, pseudoxanthoma elasticum and related disorders. In: Principles and Practice of Medical Genetics (Rimoin DL, Connor JM, Pyeritz RE, Korf BR, eds), Philadelphia: Churchill Livingstone, 3647-3670
67. Urban Z, Riazi S, Seidl TL et al. (2002) Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. Am J Hum Genet 71:30-44
68. Vogt B, Burnier M (2009) Aldosterone and cardiovascular risk. Curr Hypertens Rep 11:450-455
69. Vrhovski B, Weiss AS (1998) Biochemistry of tropoelastin. Eur J Biochem 258:1-18
70. Watson RE, Parry EJ, Humphries JD et al. (1998) Fibrillin microfibrils are reduced in skin exhibiting striae distensae. Br J Dermatol 138:931-937
71. Wolfram D, Tzankov A, Pülzl P et al. (2009) Hypertrophic scars and keloids-a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg 35:171-181
72. Xin X, Hou YT, Li L et al. (2004) IGF-I increases IGFBP-5 and collagen a1 (I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 286:G777-83
73. Yoshimoto H, Ishihara H, Ohtsuru A et al. (1999) Overexpression of insulinlike growth factor-1 (IGF-I) receptor and the invasiveness of cultured keloid fibroblasts. Am J Pathol 154:883-889
74. Youn CS, Kwon OS, Won CH et al. (2003) Effect of pregnancy and menopause on facial wrinkling in women. Acta Dermatol Venereol 83:419-424
75. Zheng P, Lavker RM, Kligman AM (1985) Anatomy of striae. Br J Dermatol 112:185-193
76. Zouboulis C (2003) Intrinsic skin aging. A critical appraisal of the role of hormones. Hautarzt 54:825-832