Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Gα13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16633-16647

  Bunda, Severa ^a   Wang, Yanting ^a   Mitts, Thomas F ^a   Liu, Peter ^b,c   Arab, Sara ^c   Arabkhari, Majid ^a   Hinek, Aleksander ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC FIBROBLASTS; CELLULAR SIGNALING; ELASTIN PRODUCTION; ELASTOGENESIS; HETEROTRIMERIC G PROTEINS; INDEPENDENT ACTION; INSULIN-LIKE GROWTH FACTOR-I; MINERALOCORTICOID RECEPTORS; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL; SIGNALING COMPONENTS; SIGNALING PATHWAYS; SMALL INTERFERING RNA; TRANSIENT INTERACTIONS;

BIOACTIVITY; CELL CULTURE; FIBROBLASTS; GLYCOPROTEINS; INSULIN; NUCLEIC ACIDS; PEPTIDES; PIGMENTS; RNA;

SIGNALING;

ALDOSTERONE; ELASTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN G ALPHA13; MINERALOCORTICOID RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE P60; SMALL INTERFERING RNA; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALDOSTERONE; CELLS, CULTURED; ELASTIN; FIBROBLASTS; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HUMANS; MYOCARDIUM; PEPTIDES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RECEPTOR, IGF TYPE 1; RECEPTORS, MINERALOCORTICOID; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 67650264048     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.008748     Document Type: Article

References (78)

1. Jennings, D. L., Kalus, J. S., and O'Dell, K. M. (2005) Pharmacotherapy 25, 1126-1133
2. Connell, J. M., and Davies, E. (2005) J. Endocrinol. 186, 1-20
3. Weber, K. T., and Brilla, C. G. (1991) Circulation 83, 1849-1865
4. Brilla, C. G., Matsubara, L. S., and Weber, K. T. (1993) Am. J. Cardiol. 71, 12A-16A
5. Young, M., Fullerton, M., Dilley, R., and Funder, J. (1994) J. Clin. Investig. 93, 2578-2583
6. Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., and Wittes, J. (1999) N. Engl. J. Med. 341, 709-717
7. Pitt, B., Remme, W., Zannad, F., Neaton, J., Martinez, F., Roniker, B., Bittman, R., Hurley, S., Kleiman, J., and Gatlin, M. (2003) N. Engl. J. Med. 348, 1309-1321
8. Zannad, F., Alla, F., Dousset, B., Perez, A., and Pitt, B. (2000) Circulation 102, 2700-2706
9. Zannad, F., Dousset, B., and Alla, F. (2001) Hypertension 38, 1227-1232
10. Christ, M., Sippel, K., Eisen, C., and Wehling, M. (1994) Mol. Cell. Endocrinol. 99, R31-34
11. Haseroth, K., Gerdes, D., Berger, S., Feuring, M., Günther, A., Herbst, C., Christ, M., and Wehling, M. (1999) Biochem. Biophys. Res. Commun. 266, 257-261
12. Chai, W., Garrelds, I. M., de Vries, R., Batenburg, W. W., van Kats, J. P., and Danser, A. H. (2005) Hypertension 46, 701-706
13. Gekle, M., Silbernagl, S., and Wünsch, S. (1998) J. Physiol. 511, 255-263.
14. Maihailidou, A. S. (2006) Steroids 71, 277-280
15. Böhmer, S., Carapito, C., Wilzewski, B., Leize, E., Van Dorsselaer, A., and Bernhardt, R. (2006) Biol. Chem. 387, 917-929
16. Eisen, C., Meyer, C., Christ, M., Theisen, K., and Wehling, M. (1994) Cell. Mol. Biol. 40, 351-358
17. Urbach, V., and Harvey, B. J. (2001) J. Physiol. 537, 267-275
18. Bunda, S., Liu, P., Wang, Y., Liu, K., and Hinek, A. (2007) Am. J. Pathol. 171, 809-819
19. Erlanger, B. F., Borek, F., Beiser, S. M., and Lieberman, S. (1957) J. Biol. Chem. 228, 713-727
20. Coles, J. G., Boscarino, C., Takahashi, M., Grant, D., Chang, A., Ritter, J., Dai, X., Du, C., Musso, G., Yamabi, H., Goncalves, J., Kumar, A. S., Woodgett, J., Lu, H., and Hannigan, G. (2005) J. Thorac. Cardiovasc. Surg. 129, 1128-1136
21. Gustafsson, A. B., and Brunton, L. L. (2000) Mol. Pharmacol. 58, 1470-1478
22. Zhou, G., Kandala, J. C., Tyagi, S. C., Katwa, L. C., and Weber, K. T. (1996) Mol. Cell. Biochem. 154, 171-178
23. Le Moëllic, C., Ouvrard-Pascaud, A., Capurro, C., Cluzeaud, F., Fay, M., Jaisser, F., Farman, N., and Blot-Chabaud, M. (2004) J. Am. Soc. Nephrol. 15, 1145-1160
24. Arima, S. (2006) Steroids 71, 281-285
25. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., and Saltiel, A. R. (1995) J. Biol. Chem. 270, 27489-27494
26. Nagai, Y., Miyata, K., Sun, G. P., Rahman, M., Kimura, S., Miyatake, A., Kiyomoto, H., Kohno, M., Abe, Y., Yoshizumi, M., and Nishiyama, A. (2005) Hypertension 46, 1039-1045
27. Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S. S., Manning, A. M., and Anderson, D. W. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 13681-13686
28. Nishida, M., Onohara, N., Sato, Y., Suda, R., Ogushi, M., Tanabe, S., Inoue, R., Mori, Y., and Kurose, H. (2007) J. Biol. Chem. 282, 23117-23128
29. Nakamura, I., Takahashi, N., Sasaki, T., Tanaka, S., Udagawa, N., Murakami, H., Kimura, K., Kabuyama, Y., Kurokawa, T., Suda, T., and Fukui, Y. (1995) FEBS Lett. 361, 79-84
30. Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y., and Matsuda, Y. (1993) J. Biol. Chem. 268, 25846-25856
31. Karni, R., Mizrachi, S., Reiss-Sklan, E., Gazit, A., Livnah, O., and Levitzki, A. (2003) FEBS Lett. 537, 47-52
32. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., and Narumiya, S. (1997) Nature 389, 990-994
33. Yanazume, T., Hasegawa, K., Wada, H., Morimoto, T., Abe, M., Kawamura, T., and Sasayama, S. (2002) J. Biol. Chem. 277, 8618-8625
34. Ji, H., Leung, M., Zhang, Y., Catt, K. J., and Sandberg, K. (1994) J. Biol. Chem. 269, 16533-16536
35. Hafizi, S., Wharton, J., Morgan, K., Allen, S. P., Chester, A. H., Catravas, J. D., Polak, J. M., and Yacoub, M. H. (1998) Circulation 98, 2553-2559
36. Widdop, R. E., Gardiner, S. M., Kemp, P. A., and Bennett, T. (1993) Am. J. Physiol. Heart Circ. Physiol. 265, H226-231
37. Jiang, X. Y., Gao, G. D., Du, X. J., Zhou, J., Wang, X. F., and Lin, Y. X. (2007) Acta Cardiol. 62, 429-438
38. Yamaguchi, Y., Katoh, H., and Negishi, M. (2003) J. Biol. Chem. 278, 14936-14939
39. Hinek, A., and Rabinovitch, M. (1994) J. Cell Biol. 126, 563-574
40. Hinek, A., and Rabinovitch, M. (1993) J. Biol. Chem. 268, 1405-1413
41. Rodems, S. M., and Spector, D. H. (1998) J. Virol. 72, 9173-9180
42. Hinek, A., Rabinovitch, M., Keeley, F., Okamura-Oho, Y., and Callahan, J. (1993) J. Clin. Investig. 91, 1198-1205
43. Krumins, A. M., and Gilman, A. G. (2006) J. Biol. Chem. 281, 10250-10262
44. Mazak, I., Fiebeler, A., Muller, D. N., Park, J. K., Shagdarsuren, E., Lindschau, C., Dechend, R., Viedt, C., Pilz, B., Haller, H., and Luft, F. C. (2004) Circulation 109, 2792-2800
45. Xiao, F., Puddefoot, J. R., Barker, S., and Vinson, G. P. (2004) Hypertension 44, 340-345
46. Simoncini, T., Scorticati, C., Mannella, P., Fadiel, A., Giretti, M. S., Fu, X. D., Baldacci, C., Garibaldi, S., Caruso, A., Fornari, L., Naftolin, F., and Genazzani, A. R. (2006) Mol. Endocrinol. 20, 1756-1771
47. Kim, S., Jin, J., and Kunapuli, S. P. (2006) Blood 107, 947-954
48. Hart, M. J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W. D., Gilman, A. G., Sternweis, P. C., and Bollag, G. (1998) Science 280, 2112-2114
49. Li, L. (2003) Crit. Rev. Oral Biol. Med. 14, 100-114
50. Roskoski, R., Jr. (2005) Biochem. Biophys. Res. Commun. 331, 1-14
51. LeRoith, D., Werner, H., Beitner-Johnson, D., and Roberts, C. T., Jr. (1995) Endocr. Rev. 16, 143-163
52. Wildling, L., Hinterdorfer, P., Kusche-Vihrog, K., Treffner, Y., and Oberleithner, H. (2009) Pflugers Arch., in press
53. Wehling, M., Eisen, C., and Christ, M. (1992) Mol. Cell. Endocrinol. 90, 5-9
54. Meyer, C., Christ, M., and Wehling, M. (1995) Eur. J. Biochem. 229, 736-740
55. Losel, R. M., and Wehling, M. (2008) Front. Neuroendocrinol. 29, 258-267
56. Zhu, Y., Rice, C. D., Pang, Y., Pace, M., and Thomas, P. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2231-2236
57. Filardo, E. J., Quinn, J. A., Bland, K. I., and Frackelton, A. R., Jr. (2000) Mol. Endocrinol. 14, 1649-1660
58. Filardo, E. J., Quinn, J. A., Frackelton, A. R., Jr., and Bland, K. I. (2002) Mol. Endocrinol. 16, 70-84
59. Filardo, E. J., Quinn, J. A., and Sabo, E. (2008) Steroids 73, 870-873
60. Zhu, Y., Bond, J., and Thomas, P. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2237-2242
61. Adarichev, V. A., Vaiskunaite, R., Niu, J., Balyasnikova, I. V., and Voyno-Yasenetskaya, T. A. (2003) Am. J. Physiol. Cell Physiol 285, C922-934
62. Kim, M., Nozu, F., Kusama, K., and Imawari, M. (2006) Biochem. Biophys. Res. Commun. 339, 271-276
63. Minuz, P., Fumagalli, L., Gaino, S., Tommasoli, R. M., Degan, M., Cavallini, C., Lecchi, A., Cattaneo, M., Lechi Santonastaso, C., and Berton, G. (2006) Biochem. J. 400, 127-134
64. Dib, K., Melander, F., and Andersson, T. (2001) J. Immunol. 166, 6311-6322
65. Klages, B., Brandt, U., Simon, M. I., Schultz, G., and Offermanns, S. (1999) J. Cell Biol. 144, 745-754
66. Kurose, H. (2003) Life Sci 74, 155-161
67. Shi, C. S., Sinnarajah, S., Cho, H., Kozasa, T., and Kehrl, J. H. (2000) J. Biol. Chem. 275, 24470-24476
68. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A., and Schlessinger, J. (1996) Nature 383, 547-550
69. Li, J., Avraham, H., Rogers, R. A., Raja, S., and Avraham, S. (1996) Blood 88, 417-428
70. Peterson, J. E., Kulik, G., Jelinek, T., Reuter, C. W., Shannon, J. A., and Weber, M. J. (1996) J. Biol. Chem. 271, 31562-31571
71. Liu, D., Zong, C. S., and Wang, L. H. (1993) J. Virol. 67, 6835-6840
72. Jiang, Y., Chan, J. L., Zong, C. S., and Wang, L. H. (1996) J. Biol. Chem. 271, 160-167
73. Ando, A., Momomura, K., Tobe, K., Yamamoto-Honda, R., Sakura, H., Tamori, Y., Kaburagi, Y., Koshio, O., Akanuma, Y., and Yazaki, Y. (1992) J. Biol. Chem. 267, 12788-12796
74. Wolfe, B. L., Rich, C. B., Goud, H. D., Terpstra, A. J., Bashir, M., Rosenbloom, J., Sonenshein, G. E., and Foster, J. A. (1993) J. Biol. Chem. 268, 12418-12426
75. Jensen, D. E., Rich, C. B., Terpstra, A. J., Farmer, S. R., and Foster, J. A. (1995) J. Biol. Chem. 270, 6555-6563
76. Conn, K. J., Rich, C. B., Jensen, D. E., Fontanilla, M. R., Bashir, M. M., Rosenbloom, J., and Foster, J. A. (1996) J. Biol. Chem. 271, 28853-28860
77. Mita, M. M., Mita, A., and Rowinsky, E. K. (2003) Cancer Biol. Ther. 2, 169-177
78. Kuang, P. P., Zhang, X. H., Rich, C. B., Foster, J. A., Subramanian, M., and Goldstein, R. H. (2007) Am. J. Physiol. Lung Cell Mol. Physiol. 292, L944-952