Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the alzheimer's disease TgCRND8 mouse model

Journal of Alzheimer's Disease

Volumn 29, Issue 2, 2012, Pages 293-308

  Krantic, Slavica ^a,b   Isorce, Nathalie ^b   Mechawar, Naguib ^b   Davoli, Maria Antonietta ^b   Vignault, Erika ^b   Albuquerque, Marilia ^b   Chabot, Jean Guy ^b   Moyse, Emmanuel ^c   Chauvin, Jean Pierre ^d   Aubert, Isabelle ^e,f   McLaurin, Joanne ^f,g   Quirion, Rémi ^b  

^a INSERM   (France)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^c University of Mediterranée   (France)

^d AIX MARSEILLE UNIVERSITÉ   (France)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alzheimer's disease; amyloid beta protein; GABAergic neurons; hippocampus; neuronal cell death; primary cell culture; TgCRND8 mice

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA ACTIN; GLUTAMATE DECARBOXYLASE 67; OLIGOMER;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL COUNT; CONTROLLED STUDY; GABAERGIC SYSTEM; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SEIZURE; SENILE PLAQUE; TRANSGENIC MOUSE;

EID: 84859390704     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110830     Document Type: Article

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