-
1
-
-
0346492952
-
Paraneoplastic neurological degenerations: keys to tumour immunity
-
Albert ML, Darnell RB. 2004. Paraneoplastic neurological degenerations: keys to tumour immunity. Nat. Rev. Cancer 4:36-44.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 36-44
-
-
Albert, M.L.1
Darnell, R.B.2
-
2
-
-
34547936661
-
The proteasome and its role in nuclear protein maintenance
-
Bader N, Jung T, Grune T. 2007. The proteasome and its role in nuclear protein maintenance. Exp. Gerontol. 42:864-870.
-
(2007)
Exp. Gerontol.
, vol.42
, pp. 864-870
-
-
Bader, N.1
Jung, T.2
Grune, T.3
-
3
-
-
59349088768
-
Manipulation of the ubiquitinproteasome pathway by small DNA tumor viruses
-
Blanchette P, Branton PE. 2009. Manipulation of the ubiquitinproteasome pathway by small DNA tumor viruses. Virology 384:317-323.
-
(2009)
Virology
, vol.384
, pp. 317-323
-
-
Blanchette, P.1
Branton, P.E.2
-
4
-
-
0034282102
-
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
-
Boyd SD, Tsai KY, Jacks T. 2000. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat. Cell Biol. 2:563-568.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 563-568
-
-
Boyd, S.D.1
Tsai, K.Y.2
Jacks, T.3
-
5
-
-
0029100611
-
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies
-
Carvalho T, et al. 1995. Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies. J. Cell Biol. 131:45-56.
-
(1995)
J. Cell Biol.
, vol.131
, pp. 45-56
-
-
Carvalho, T.1
-
6
-
-
1842364970
-
Expression of neural BC200 RNA in human tumours
-
Chen W, Böcker W, Brosius J, Tiedge H. 1997. Expression of neural BC200 RNA in human tumours. J. Pathol. 183:345-351.
-
(1997)
J. Pathol.
, vol.183
, pp. 345-351
-
-
Chen, W.1
Böcker, W.2
Brosius, J.3
Tiedge, H.4
-
7
-
-
33745937881
-
Proteasome-dependent down-regulation of activated Stat5A in the nucleus
-
Chen Y, Dai X, Haas AL, Wen R, Wang D. 2006. Proteasome-dependent down-regulation of activated Stat5A in the nucleus. Blood 108:566 -574.
-
(2006)
Blood
, vol.108
, pp. 566-574
-
-
Chen, Y.1
Dai, X.2
Haas, A.L.3
Wen, R.4
Wang, D.5
-
8
-
-
0028934541
-
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons
-
Chong JA, et al. 1995. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949 -957.
-
(1995)
Cell
, vol.80
, pp. 949-957
-
-
Chong, J.A.1
-
9
-
-
24044505984
-
Transcriptional regulation: cancer, neurons and the REST
-
Coulson JM. 2005. Transcriptional regulation: cancer, neurons and the REST. Curr. Biol. 15:R665-R668.
-
(2005)
Curr. Biol.
, vol.15
-
-
Coulson, J.M.1
-
10
-
-
50149109481
-
Epigenetic reprogramming by adenovirus e1a
-
Ferrari R, et al. 2008. Epigenetic reprogramming by adenovirus e1a. Science 321:1086 -1088.
-
(2008)
Science
, vol.321
, pp. 1086-1088
-
-
Ferrari, R.1
-
11
-
-
65649115267
-
Recognition and processing of ubiquitin-protein conjugates by the proteasome
-
Finley D. 2009. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem. 78:477-513.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 477-513
-
-
Finley, D.1
-
12
-
-
0035933828
-
The nuclear ubiquitin-proteasome system degrades MyoD
-
Floyd ZE, Trausch-Azar JS, Reinstein E, Ciechanover A, Schwartz AL. 2001. The nuclear ubiquitin-proteasome system degrades MyoD. J. Biol. Chem. 276:22468 -22475.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22468-22475
-
-
Floyd, Z.E.1
Trausch-Azar, J.S.2
Reinstein, E.3
Ciechanover, A.4
Schwartz, A.L.5
-
13
-
-
44349122993
-
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
-
Frescas D, Pagano M. 2008. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat. Rev. Cancer 8:438-449.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 438-449
-
-
Frescas, D.1
Pagano, M.2
-
14
-
-
1942502180
-
The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer
-
Fuchs SY, Spiegelman VS, Kumar KG. 2004. The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23:2028 -2036.
-
(2004)
Oncogene
, vol.23
, pp. 2028-2036
-
-
Fuchs, S.Y.1
Spiegelman, V.S.2
Kumar, K.G.3
-
15
-
-
0035923583
-
Diversity of gene expression in adenocarcinoma of the lung
-
Garber ME, et al. 2001. Diversity of gene expression in adenocarcinoma of the lung. Proc. Natl. Acad. Sci. U. S. A. 98:13784 -13789.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 13784-13789
-
-
Garber, M.E.1
-
16
-
-
58249105893
-
Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence
-
Garrenton LS, et al. 2009. Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence. Mol. Cell. Biol. 29:582- 601.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 582-601
-
-
Garrenton, L.S.1
-
17
-
-
79955906148
-
Distinct gene expression profiles directed by the isoforms of the transcription factor neuron-restrictive silencer factor in human SK-N-AS neuroblastoma cells
-
Gillies SG, et al. 2011. Distinct gene expression profiles directed by the isoforms of the transcription factor neuron-restrictive silencer factor in human SK-N-AS neuroblastoma cells. J. Mol. Neurosci. 44:77-90.
-
(2011)
J. Mol. Neurosci.
, vol.44
, pp. 77-90
-
-
Gillies, S.G.1
-
18
-
-
67149121885
-
REST and the RESTless: in stem cells and beyond
-
Gopalakrishnan V. 2009. REST and the RESTless: in stem cells and beyond. Future Neurol. 4:317-329.
-
(2009)
Future Neurol
, vol.4
, pp. 317-329
-
-
Gopalakrishnan, V.1
-
19
-
-
33847349997
-
Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer
-
Gröne J, et al. 2006. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. Oncol. Rep. 15:1437-1443.
-
(2006)
Oncol. Rep.
, vol.15
, pp. 1437-1443
-
-
Gröne, J.1
-
20
-
-
15444363021
-
DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit
-
Guan H, Hou S, Ricciardi RP. 2005. DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit. J. Biol. Chem. 280:9957-9962.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9957-9962
-
-
Guan, H.1
Hou, S.2
Ricciardi, R.P.3
-
21
-
-
37349051694
-
Tumorigenic adenovirus type 12 E1A inhibits phosphorylation of NF-kappaB by PKAc, causing loss of DNA binding and transactivation
-
Guan H, Jiao J, Ricciardi RP. 2008. Tumorigenic adenovirus type 12 E1A inhibits phosphorylation of NF-kappaB by PKAc, causing loss of DNA binding and transactivation. J. Virol. 82:40-48.
-
(2008)
J. Virol.
, vol.82
, pp. 40-48
-
-
Guan, H.1
Jiao, J.2
Ricciardi, R.P.3
-
22
-
-
58149502624
-
Induction of neuronal and tumor-related genes by adenovirus type 12 E1A
-
Guan H, Williams JF, Ricciardi RP. 2009. Induction of neuronal and tumor-related genes by adenovirus type 12 E1A. J. Virol. 83:651- 661.
-
(2009)
J. Virol.
, vol.83
, pp. 651-661
-
-
Guan, H.1
Williams, J.F.2
Ricciardi, R.P.3
-
23
-
-
41149130221
-
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
-
Guardavaccaro D, et al. 2008. Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 452:365-369.
-
(2008)
Nature
, vol.452
, pp. 365-369
-
-
Guardavaccaro, D.1
-
24
-
-
0029957644
-
mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect
-
Hateboer G, et al. 1996. mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect. J. Biol. Chem. 271: 25906-25911.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25906-25911
-
-
Hateboer, G.1
-
25
-
-
70350439112
-
Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase
-
Isobe T, et al. 2009. Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase. J. Biol. Chem. 284:27766 -27779.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 27766-27779
-
-
Isobe, T.1
-
26
-
-
0026651714
-
Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad12 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host range
-
Jelinek T, Graham FL. 1992. Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad12 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host range. J. Virol. 66:4117- 4125.
-
(1992)
J. Virol.
, vol.66
, pp. 4117-4125
-
-
Jelinek, T.1
Graham, F.L.2
-
27
-
-
0028044756
-
Tumorigenicity of adenovirustransformed rodent cells is influenced by at least two regions of adenovirus type 12 early region 1A
-
Jelinek T, Pereira DS, Graham FL. 1994. Tumorigenicity of adenovirustransformed rodent cells is influenced by at least two regions of adenovirus type 12 early region 1A. J. Virol. 68:888-896.
-
(1994)
J. Virol.
, vol.68
, pp. 888-896
-
-
Jelinek, T.1
Pereira, D.S.2
Graham, F.L.3
-
28
-
-
0030824576
-
Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element
-
Kallunki P, Edelman GM, Jones FS. 1997. Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element. J. Cell Biol. 138:1343-1354.
-
(1997)
J. Cell Biol.
, vol.138
, pp. 1343-1354
-
-
Kallunki, P.1
Edelman, G.M.2
Jones, F.S.3
-
29
-
-
50849103324
-
Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation
-
Kim CS, et al. 2008. Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation. Biochim. Biophys. Acta 1783: 1835-1846.
-
(2008)
Biochim. Biophys. Acta
, vol.1783
, pp. 1835-1846
-
-
Kim, C.S.1
-
30
-
-
0032980566
-
Reduced phosphorylation of p50 is responsible for diminished NF-kappaB binding to the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells
-
Kushner DB, Ricciardi RP. 1999. Reduced phosphorylation of p50 is responsible for diminished NF-kappaB binding to the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells. Mol. Cell. Biol. 19:2169 -2179.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2169-2179
-
-
Kushner, D.B.1
Ricciardi, R.P.2
-
31
-
-
0036678202
-
Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome
-
Lafarga M, et al. 2002. Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. Mol. Biol. Cell 13:2771-2782.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 2771-2782
-
-
Lafarga, M.1
-
32
-
-
0034233725
-
Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element
-
Lee JH, Shimojo M, Chai YG, Hersh LB. 2000. Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element. Brain Res. Mol. Brain Res. 80:88 -98.
-
(2000)
Brain Res. Mol Brain Res.
, vol.80
, pp. 88-98
-
-
Lee, J.H.1
Shimojo, M.2
Chai, Y.G.3
Hersh, L.B.4
-
33
-
-
0033257926
-
Ubiquitin-dependent degradation of TGF-betaactivated smad2
-
Lo RS, Massague J. 1999. Ubiquitin-dependent degradation of TGF-betaactivated smad2. Nat. Cell Biol. 1:472- 478.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 472-478
-
-
Lo, R.S.1
Massague, J.2
-
34
-
-
19344372003
-
No rest for REST: REST/NRSF regulation of neurogenesis
-
Lunyak VV, Rosenfeld MG. 2005. No rest for REST: REST/NRSF regulation of neurogenesis. Cell 121:499 -501.
-
(2005)
Cell
, vol.121
, pp. 499-501
-
-
Lunyak, V.V.1
Rosenfeld, M.G.2
-
35
-
-
33748921564
-
REST in good times and bad: roles in tumor suppressor and oncogenic activities
-
Majumder S. 2006. REST in good times and bad: roles in tumor suppressor and oncogenic activities. Cell Cycle 5:1929 -1935.
-
(2006)
Cell Cycle
, vol.5
, pp. 1929-1935
-
-
Majumder, S.1
-
36
-
-
0031590459
-
Induction of ubiquitin conjugating enzyme activity for degradation of topoisomerase II alpha during adenovirus E1Ainduced apoptosis
-
Nakajima T, et al. 1997. Induction of ubiquitin conjugating enzyme activity for degradation of topoisomerase II alpha during adenovirus E1Ainduced apoptosis. Biochem. Biophys. Res. Commun. 239:823- 829.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.239
, pp. 823-829
-
-
Nakajima, T.1
-
37
-
-
0032519868
-
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene
-
Palm K, Belluardo N, Metsis M, Timmusk T. 1998. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci. 18:1280 -1296.
-
(1998)
J. Neurosci.
, vol.18
, pp. 1280-1296
-
-
Palm, K.1
Belluardo, N.2
Metsis, M.3
Timmusk, T.4
-
38
-
-
47749130885
-
Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes
-
Pelka P, Ablack JN, Fonseca GJ, Yousef AF, Mymryk JS. 2008. Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes. J. Virol. 82:7252-7263.
-
(2008)
J. Virol.
, vol.82
, pp. 7252-7263
-
-
Pelka, P.1
Ablack, J.N.2
Fonseca, G.J.3
Yousef, A.F.4
Mymryk, J.S.5
-
39
-
-
63149136975
-
RE- 1-silencing transcription factor shows tumor-suppressor functions and negatively regulates the oncogenic TAC1 in breast cancer cells
-
Reddy BY, Greco SJ, Patel PS, Trzaska KA, Rameshwar P. 2009. RE-1-silencing transcription factor shows tumor-suppressor functions and negatively regulates the oncogenic TAC1 in breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 106:4408-4413.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 4408-4413
-
-
Reddy, B.Y.1
Greco, S.J.2
Patel, P.S.3
Trzaska, K.A.4
Rameshwar, P.5
-
40
-
-
0003122784
-
Transformation and tumorigenesis mediated by the adenovirus E1A and E1B oncogenes
-
Barbanti-Brodano G, Bendinelli M, Friedman H (ed), Plenum Press, New York, NY
-
Ricciardi R. 1995. Transformation and tumorigenesis mediated by the adenovirus E1A and E1B oncogenes, p 195-225. In Barbanti-Brodano G, Bendinelli M, Friedman H (ed), DNA tumor viruses: oncogenic mechanisms. Plenum Press, New York, NY.
-
(1995)
DNA tumor viruses: oncogenic mechanisms
, pp. 195-225
-
-
Ricciardi, R.1
-
41
-
-
0013125810
-
Adenovirus transformation and tumorigenicity
-
Seth P (ed), Landes Biosciences/Springer, New York, NY
-
Ricciardi RP. 1999. Adenovirus transformation and tumorigenicity, p 217-227. In Seth P (ed), Adenoviruses: from basic research to gene therapy applications. Landes Biosciences/Springer, New York, NY.
-
(1999)
Adenoviruses: from basic research to gene therapy applications
, pp. 217-227
-
-
Ricciardi, R.P.1
-
42
-
-
77954462208
-
Mechanism of tumorigenesis mediated by adenovirus-12 E1A
-
Tognon M (ed), Research Signpost, Kerala, India
-
Ricciardi RP, Zhao B, Guan H. 2006. Mechanism of tumorigenesis mediated by adenovirus-12 E1A, p 107-124. In Tognon M (ed), Viral oncogenesis. Research Signpost, Kerala, India.
-
(2006)
Viral oncogenesis
, pp. 107-124
-
-
Ricciardi, R.P.1
Zhao, B.2
Guan, H.3
-
43
-
-
0032518917
-
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
-
Roth J, Dobbelstein M, Freedman DA, Shenk T, Levine AJ. 1998. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17:554 -564.
-
(1998)
EMBO J
, vol.17
, pp. 554-564
-
-
Roth, J.1
Dobbelstein, M.2
Freedman, D.A.3
Shenk, T.4
Levine, A.J.5
-
44
-
-
34249934582
-
Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry
-
Scharf A, Rockel TD, von Mikecz A. 2007. Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry. Histochem. Cell Biol. 127:591- 601.
-
(2007)
Histochem. Cell Biol.
, vol.127
, pp. 591-601
-
-
Scharf, A.1
Rockel, T.D.2
von Mikecz, A.3
-
46
-
-
13944252067
-
The life cycle of C-myc: from synthesis to degradation
-
Sears RC. 2004. The life cycle of C-myc: from synthesis to degradation. Cell Cycle 3:1133-1137.
-
(2004)
Cell Cycle
, vol.3
, pp. 1133-1137
-
-
Sears, R.C.1
-
47
-
-
43449100341
-
REST maintains self-renewal and pluripotency of embryonic stem cells
-
Singh SK, Kagalwala MN, Parker-Thornburg J, Adams H, Majumder S. 2008. REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 453:223-227.
-
(2008)
Nature
, vol.453
, pp. 223-227
-
-
Singh, S.K.1
Kagalwala, M.N.2
Parker-Thornburg, J.3
Adams, H.4
Majumder, S.5
-
48
-
-
71649104466
-
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
-
Suizu F, et al. 2009. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev. Cell 17:800-810.
-
(2009)
Dev. Cell
, vol.17
, pp. 800-810
-
-
Suizu, F.1
-
50
-
-
0034282565
-
Regulation of the 26S proteasome by adenovirus E1A
-
Turnell AS, et al. 2000. Regulation of the 26S proteasome by adenovirus E1A. EMBO J. 19:4759-4773.
-
(2000)
EMBO J
, vol.19
, pp. 4759-4773
-
-
Turnell, A.S.1
-
51
-
-
77954154641
-
The transcription factor REST is lost in aggressive breast cancer
-
Wagoner MP, et al. 2010. The transcription factor REST is lost in aggressive breast cancer. PLoS Genet. 6:e1000979.
-
(2010)
PLoS Genet
, vol.6
-
-
Wagoner, M.P.1
-
52
-
-
41149119961
-
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation
-
Westbrook TF, et al. 2008. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452: 370-374.
-
(2008)
Nature
, vol.452
, pp. 370-374
-
-
Westbrook, T.F.1
-
53
-
-
20444376939
-
A genetic screen for candidate tumor suppressors identifies REST
-
Westbrook TF, et al. 2005. A genetic screen for candidate tumor suppressors identifies REST. Cell 121:837- 848.
-
(2005)
Cell
, vol.121
, pp. 837-848
-
-
Westbrook, T.F.1
-
54
-
-
0141792675
-
E1A-based determinants of oncogenicity in human adenovirus groups A and C
-
Williams JF, et al. 2004. E1A-based determinants of oncogenicity in human adenovirus groups A and C. Curr. Top. Microbiol. Immunol. 273: 245-288.
-
(2004)
Curr. Top. Microbiol. Immunol.
, vol.273
, pp. 245-288
-
-
Williams, J.F.1
-
55
-
-
53249087743
-
Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells
-
Zhang P, et al. 2008. Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr. Biol. 18: 1489-1494.
-
(2008)
Curr. Biol
, vol.18
, pp. 1489-1494
-
-
Zhang, P.1
-
56
-
-
24644441892
-
Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer
-
Zhang Y, Dang C, Ma Q, Shimahara Y. 2005. Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer. Oncol. Rep. 14:161-171.
-
(2005)
Oncol. Rep.
, vol.14
, pp. 161-171
-
-
Zhang, Y.1
Dang, C.2
Ma, Q.3
Shimahara, Y.4
|