High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate

Cancer Chemotherapy and Pharmacology

Volumn 73, Issue 3, 2014, Pages 585-594

  Hanberry, Bradley S ^a   Berger, Ryan ^a   Zastre, Jason A ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Dichloroacetate; Metabolism; Pyruvate dehydrogenase; Thiamine; Vitamin

Indexed keywords

CASPASE 3; DICHLOROACETIC ACID; HYDROGEN PEROXIDE; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; THIAMINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REACTIVATION; GLUCOSE ASSAY; GLUCOSE INTAKE; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DICHLOROACETIC ACID; GLUCOSE; HUMANS; LACTIC ACID; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEUROBLASTOMA; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN SPECIES; THIAMINE;

EID: 84896057721     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-014-2386-z     Document Type: Article

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