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Volumn 63, Issue 8, 2008, Pages 759-765

Effect of Chronic Antipsychotic Exposure on Astrocyte and Oligodendrocyte Numbers in Macaque Monkeys

Author keywords

Astrocyte; haloperidol; macaque monkeys; olanzapine; oligodendrocyte; stereology

Indexed keywords

HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE;

EID: 40849103017     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.08.018     Document Type: Article
Times cited : (224)

References (47)
  • 1
    • 0034481144 scopus 로고    scopus 로고
    • Cognitive impairment in schizophrenia is the core of the disorder
    • Elvevåg B., and Goldberg T.E. Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol 14 (2000) 1-21
    • (2000) Crit Rev Neurobiol , vol.14 , pp. 1-21
    • Elvevåg, B.1    Goldberg, T.E.2
  • 2
    • 0030910613 scopus 로고    scopus 로고
    • Increased phosphorylation of myelin basic protein during hippocampal long-term potentiation
    • Atkins C.M., Chen S.J., Klann E., and Sweatt J.D. Increased phosphorylation of myelin basic protein during hippocampal long-term potentiation. J Neurochem 68 (1997) 1960-1967
    • (1997) J Neurochem , vol.68 , pp. 1960-1967
    • Atkins, C.M.1    Chen, S.J.2    Klann, E.3    Sweatt, J.D.4
  • 3
    • 0027167822 scopus 로고
    • Brain magnetic resonance imaging correlates of cognitive impairment in multiple sclerosis
    • Comi G., Filippi M., Martinelli V., Sirabian G., Visciani A., Campi A., et al. Brain magnetic resonance imaging correlates of cognitive impairment in multiple sclerosis. J Neurol Sci 115 suppl (1993) S66-S73
    • (1993) J Neurol Sci , vol.115 , Issue.SUPPL
    • Comi, G.1    Filippi, M.2    Martinelli, V.3    Sirabian, G.4    Visciani, A.5    Campi, A.6
  • 4
    • 10744226835 scopus 로고    scopus 로고
    • Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins
    • Flynn S.W., Lang D.J., Mackay A.L., Goghari V., Vavasour I.M., Whittall K.P., et al. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Mol Psychiatry 8 (2003) 811-820
    • (2003) Mol Psychiatry , vol.8 , pp. 811-820
    • Flynn, S.W.1    Lang, D.J.2    Mackay, A.L.3    Goghari, V.4    Vavasour, I.M.5    Whittall, K.P.6
  • 5
    • 0037839787 scopus 로고    scopus 로고
    • Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia
    • Hof P.R., Haroutunian V., Friedrich Jr. V.L., Byne W., Buitron C., Perl D.P., et al. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol Psychiatry 53 (2003) 1075-1085
    • (2003) Biol Psychiatry , vol.53 , pp. 1075-1085
    • Hof, P.R.1    Haroutunian, V.2    Friedrich Jr., V.L.3    Byne, W.4    Buitron, C.5    Perl, D.P.6
  • 6
    • 0035836642 scopus 로고    scopus 로고
    • Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
    • Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D., et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 98 (2001) 4746-4751
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4746-4751
    • Hakak, Y.1    Walker, J.R.2    Li, C.3    Wong, W.H.4    Davis, K.L.5    Buxbaum, J.D.6
  • 8
    • 20144389032 scopus 로고    scopus 로고
    • Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios
    • Yang Y.F., Qin W., Shugart Y.Y., He G., Liu X.M., Zhou J., et al. Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios. Schizophr Res 75 (2005) 11-19
    • (2005) Schizophr Res , vol.75 , pp. 11-19
    • Yang, Y.F.1    Qin, W.2    Shugart, Y.Y.3    He, G.4    Liu, X.M.5    Zhou, J.6
  • 9
    • 34249095208 scopus 로고    scopus 로고
    • Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys
    • Konopaske G.T., Dorph-Petersen K.A., Pierri J.N., Wu Q., Sampson A.R., and Lewis D.A. Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys. Neuropsychopharmacol 32 (2007) 1216-1223
    • (2007) Neuropsychopharmacol , vol.32 , pp. 1216-1223
    • Konopaske, G.T.1    Dorph-Petersen, K.A.2    Pierri, J.N.3    Wu, Q.4    Sampson, A.R.5    Lewis, D.A.6
  • 10
    • 27744569450 scopus 로고    scopus 로고
    • The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys
    • Dorph-Petersen K.A., Pierri J.N., Perel J.M., Sun Z., Sampson A.R., and Lewis D.A. The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacol 30 (2005) 1649-1661
    • (2005) Neuropsychopharmacol , vol.30 , pp. 1649-1661
    • Dorph-Petersen, K.A.1    Pierri, J.N.2    Perel, J.M.3    Sun, Z.4    Sampson, A.R.5    Lewis, D.A.6
  • 11
    • 0024250786 scopus 로고
    • Expression of the 2',3'-cyclic nucleotide 3'-phosphohydrolase gene and immunoreactive protein in oligodendrocytes as revealed by in situ hybridization and immunofluorescence
    • Vogel U.S., Reynolds R., Thompson R.J., and Wilkin G.P. Expression of the 2',3'-cyclic nucleotide 3'-phosphohydrolase gene and immunoreactive protein in oligodendrocytes as revealed by in situ hybridization and immunofluorescence. Glia 1 (1988) 184-190
    • (1988) Glia , vol.1 , pp. 184-190
    • Vogel, U.S.1    Reynolds, R.2    Thompson, R.J.3    Wilkin, G.P.4
  • 12
    • 0028870526 scopus 로고
    • S100 immunoreactivity in a subpopulation of oligodendrocytes and Ranvier's nodes of adult rat brain
    • Rickmann M., and Wolff J.R. S100 immunoreactivity in a subpopulation of oligodendrocytes and Ranvier's nodes of adult rat brain. Neurosci Lett 186 (1995) 13-16
    • (1995) Neurosci Lett , vol.186 , pp. 13-16
    • Rickmann, M.1    Wolff, J.R.2
  • 13
    • 3042664235 scopus 로고    scopus 로고
    • A randomized, controlled comparison of the efficacy and tolerability of low and high doses of haloperidol in the treatment of first-episode psychosis
    • Oosthuizen P., Emsley R., Jadri Turner H., and Keyter N. A randomized, controlled comparison of the efficacy and tolerability of low and high doses of haloperidol in the treatment of first-episode psychosis. Int J Neuropsychopharmacol 7 (2004) 125-131
    • (2004) Int J Neuropsychopharmacol , vol.7 , pp. 125-131
    • Oosthuizen, P.1    Emsley, R.2    Jadri Turner, H.3    Keyter, N.4
  • 14
    • 0035141860 scopus 로고    scopus 로고
    • Olanzapine plasma concentrations and clinical response: Acute phase results of the North American Olanzapine Trial
    • Perry P.J., Lund B.C., Sanger T., and Beasley C. Olanzapine plasma concentrations and clinical response: Acute phase results of the North American Olanzapine Trial. J Clin Psychopharmacol 21 (2001) 14-20
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 14-20
    • Perry, P.J.1    Lund, B.C.2    Sanger, T.3    Beasley, C.4
  • 15
    • 33745822796 scopus 로고    scopus 로고
    • A note on the stereological implications of irregular spacing of sections
    • Baddeley A., Dorph-Petersen K.A., and Vedel Jensen E.B. A note on the stereological implications of irregular spacing of sections. J Microsc 222 (2006) 177-181
    • (2006) J Microsc , vol.222 , pp. 177-181
    • Baddeley, A.1    Dorph-Petersen, K.A.2    Vedel Jensen, E.B.3
  • 16
    • 0037349715 scopus 로고    scopus 로고
    • The art of embedding tissue for frozen section. Part I: A system for face down cryoembedding of tissues using freezing temperature embedding wells
    • Peters S.R. The art of embedding tissue for frozen section. Part I: A system for face down cryoembedding of tissues using freezing temperature embedding wells. J Histotechnol 26 (2003) 11-19
    • (2003) J Histotechnol , vol.26 , pp. 11-19
    • Peters, S.R.1
  • 17
    • 0037351373 scopus 로고    scopus 로고
    • The art of embedding tissue for frozen section. Part II: Frozen block cryoembedding
    • Peters S.R. The art of embedding tissue for frozen section. Part II: Frozen block cryoembedding. J Histotechnol 26 (2003) 23-28
    • (2003) J Histotechnol , vol.26 , pp. 23-28
    • Peters, S.R.1
  • 18
    • 0037106148 scopus 로고    scopus 로고
    • Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    • Windrem M.S., Roy N.S., Wang J., Nunes M., Benraiss A., Goodman R., et al. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain. J Neurosci Res 69 (2002) 966-975
    • (2002) J Neurosci Res , vol.69 , pp. 966-975
    • Windrem, M.S.1    Roy, N.S.2    Wang, J.3    Nunes, M.4    Benraiss, A.5    Goodman, R.6
  • 19
    • 0031438773 scopus 로고    scopus 로고
    • 2',3'-cyclic nucleotide 3'-phosphodiesterase is associated with mitochondria in diverse adrenal cell types
    • McFerran B., and Burgoyne R. 2',3'-cyclic nucleotide 3'-phosphodiesterase is associated with mitochondria in diverse adrenal cell types. J Cell Sci 110 (1997) 2979-2985
    • (1997) J Cell Sci , vol.110 , pp. 2979-2985
    • McFerran, B.1    Burgoyne, R.2
  • 20
    • 0037370361 scopus 로고    scopus 로고
    • Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
    • Lappe-Siefke C., Goebbels S., Gravel M., Nicksch E., Lee J., Braun P.E., et al. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 33 (2003) 366-374
    • (2003) Nat Genet , vol.33 , pp. 366-374
    • Lappe-Siefke, C.1    Goebbels, S.2    Gravel, M.3    Nicksch, E.4    Lee, J.5    Braun, P.E.6
  • 21
    • 0036523140 scopus 로고    scopus 로고
    • Id-1 expression defines a subset of vimentin/S-100beta-positive, GFAP-negative astrocytes in the adult rat pineal gland
    • Kofler B., Bulleyment A., Humphries A., and Carter D.A. Id-1 expression defines a subset of vimentin/S-100beta-positive, GFAP-negative astrocytes in the adult rat pineal gland. Histochem J 34 (2002) 167-171
    • (2002) Histochem J , vol.34 , pp. 167-171
    • Kofler, B.1    Bulleyment, A.2    Humphries, A.3    Carter, D.A.4
  • 22
    • 0035297710 scopus 로고    scopus 로고
    • S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease
    • Yu W.H., and Fraser P.E. S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease. J Neurosci 21 (2001) 2240-2246
    • (2001) J Neurosci , vol.21 , pp. 2240-2246
    • Yu, W.H.1    Fraser, P.E.2
  • 23
    • 0037087213 scopus 로고    scopus 로고
    • Normal development of serotonergic neurons in mice lacking S100B
    • Nishiyama H., Takemura M., Takeda T., and Itohara S. Normal development of serotonergic neurons in mice lacking S100B. Neurosci Lett 321 (2002) 49-52
    • (2002) Neurosci Lett , vol.321 , pp. 49-52
    • Nishiyama, H.1    Takemura, M.2    Takeda, T.3    Itohara, S.4
  • 24
    • 84985187820 scopus 로고
    • Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones in the memory of William R. Thompson
    • Gundersen H.J.G. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones in the memory of William R. Thompson. J Microsc 143 (1986) 3-45
    • (1986) J Microsc , vol.143 , pp. 3-45
    • Gundersen, H.J.G.1
  • 25
    • 84981459110 scopus 로고
    • Notes on the estimation of the numerical density of arbitrary profiles: The edge effect
    • Gundersen H.J.G. Notes on the estimation of the numerical density of arbitrary profiles: The edge effect. J Microsc 111 (1977) 219-223
    • (1977) J Microsc , vol.111 , pp. 219-223
    • Gundersen, H.J.G.1
  • 27
    • 33748633649 scopus 로고    scopus 로고
    • Estimation of number and volume of immunohistochemically stained neurons in complex brain regions
    • Evans S.M., Janson A.M., and Nyengaard J.R. (Eds), Oxford University Press, Oxford
    • Dorph-Petersen K.A., Rosenberg R., and Nyengaard J.R. Estimation of number and volume of immunohistochemically stained neurons in complex brain regions. In: Evans S.M., Janson A.M., and Nyengaard J.R. (Eds). Quantitative Methods in Neuroscience (2004), Oxford University Press, Oxford 16-238
    • (2004) Quantitative Methods in Neuroscience , pp. 16-238
    • Dorph-Petersen, K.A.1    Rosenberg, R.2    Nyengaard, J.R.3
  • 28
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West M.J., Slomianka L., and Gundersen H.J.G. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231 (1991) 482-497
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.G.3
  • 29
    • 0019485653 scopus 로고
    • Optimizing sampling efficiency of stereological studies in biology: Or 'do more less well!'
    • Gundersen H.J.G., and Østerby R. Optimizing sampling efficiency of stereological studies in biology: Or 'do more less well!'. J Microsc 121 (1981) 65-73
    • (1981) J Microsc , vol.121 , pp. 65-73
    • Gundersen, H.J.G.1    Østerby, R.2
  • 30
    • 0033045425 scopus 로고    scopus 로고
    • The efficiency of systematic sampling in stereology-reconsidered
    • Gundersen H.J.G., Jensen E.B.V., Kiêu K., and Nielsen J. The efficiency of systematic sampling in stereology-reconsidered. J Microsc 193 (1999) 199-211
    • (1999) J Microsc , vol.193 , pp. 199-211
    • Gundersen, H.J.G.1    Jensen, E.B.V.2    Kiêu, K.3    Nielsen, J.4
  • 31
    • 1942484894 scopus 로고    scopus 로고
    • Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: Volume, neuron number, and cell types
    • Dorph-Petersen K.A., Pierri J.N., Sun Z., Sampson A.R., and Lewis D.A. Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: Volume, neuron number, and cell types. J Comp Neurol 472 (2004) 449-462
    • (2004) J Comp Neurol , vol.472 , pp. 449-462
    • Dorph-Petersen, K.A.1    Pierri, J.N.2    Sun, Z.3    Sampson, A.R.4    Lewis, D.A.5
  • 32
    • 24944511483 scopus 로고    scopus 로고
    • Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus
    • Sweet R.A., Dorph-Petersen K.A., and Lewis D.A. Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus. J Comp Neurol 491 (2005) 270-289
    • (2005) J Comp Neurol , vol.491 , pp. 270-289
    • Sweet, R.A.1    Dorph-Petersen, K.A.2    Lewis, D.A.3
  • 33
    • 0032967875 scopus 로고    scopus 로고
    • The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D1, D2, D3, 5HT2A and muscarinic receptors
    • (Berl)
    • Zhang W., and Bymaster F.P. The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D1, D2, D3, 5HT2A and muscarinic receptors. Psychopharmacology 141 (1999) 267-278 (Berl)
    • (1999) Psychopharmacology , vol.141 , pp. 267-278
    • Zhang, W.1    Bymaster, F.P.2
  • 35
    • 2442546861 scopus 로고    scopus 로고
    • Intercellular metabolic compartmentation in the brain: Past, present and future
    • Hertz L. Intercellular metabolic compartmentation in the brain: Past, present and future. Neurochem Int 45 (2004) 285-296
    • (2004) Neurochem Int , vol.45 , pp. 285-296
    • Hertz, L.1
  • 36
    • 4644228386 scopus 로고    scopus 로고
    • The GABA-glutamate connection in schizophrenia: Which is the proximate cause?
    • Coyle J.T. The GABA-glutamate connection in schizophrenia: Which is the proximate cause?. Biochem Pharmacol 68 (2004) 1507-1514
    • (2004) Biochem Pharmacol , vol.68 , pp. 1507-1514
    • Coyle, J.T.1
  • 37
    • 33748474553 scopus 로고    scopus 로고
    • Pathophysiologically based treatment interventions in schizophrenia
    • Lewis D.A., and Gonzalez-Burgos G. Pathophysiologically based treatment interventions in schizophrenia. Nat Med 12 (2006) 1016-1022
    • (2006) Nat Med , vol.12 , pp. 1016-1022
    • Lewis, D.A.1    Gonzalez-Burgos, G.2
  • 38
    • 33745893228 scopus 로고    scopus 로고
    • The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transfer
    • Bak L.K., Schousboe A., and Waagepetersen H.S. The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transfer. J Neurochem 98 (2006) 641-653
    • (2006) J Neurochem , vol.98 , pp. 641-653
    • Bak, L.K.1    Schousboe, A.2    Waagepetersen, H.S.3
  • 39
    • 2942594018 scopus 로고    scopus 로고
    • Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission
    • Schousboe A., Sarup A., Bak L.K., Waagepetersen H.S., and Larsson O.M. Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission. Neurochem Int 45 (2004) 521-527
    • (2004) Neurochem Int , vol.45 , pp. 521-527
    • Schousboe, A.1    Sarup, A.2    Bak, L.K.3    Waagepetersen, H.S.4    Larsson, O.M.5
  • 40
    • 0029114107 scopus 로고
    • Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry
    • Chaudhry F.A., Lehre K.P., van Lookeren Campagne M., Ottersen O.P., Danbolt N.C., and Storm-Mathisen J. Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron 15 (1995) 711-720
    • (1995) Neuron , vol.15 , pp. 711-720
    • Chaudhry, F.A.1    Lehre, K.P.2    van Lookeren Campagne, M.3    Ottersen, O.P.4    Danbolt, N.C.5    Storm-Mathisen, J.6
  • 42
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes of rat brain
    • Norenberg M.D., and Martinez-Hernandez A. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 161 (1979) 303-310
    • (1979) Brain Res , vol.161 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 43
    • 0038469628 scopus 로고    scopus 로고
    • Transfer of glutamine between astrocytes and neurons
    • Bröer S., and Brookes N. Transfer of glutamine between astrocytes and neurons. J Neurochem 77 (2001) 705-719
    • (2001) J Neurochem , vol.77 , pp. 705-719
    • Bröer, S.1    Brookes, N.2
  • 44
    • 0036843574 scopus 로고    scopus 로고
    • Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers
    • Théberge J., Bartha R., Drost D.J., Menon R.S., Malla A., Takhar J., et al. Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers. Am J Psychiatry 159 (2002) 1944-1946
    • (2002) Am J Psychiatry , vol.159 , pp. 1944-1946
    • Théberge, J.1    Bartha, R.2    Drost, D.J.3    Menon, R.S.4    Malla, A.5    Takhar, J.6
  • 45
    • 7244220611 scopus 로고    scopus 로고
    • Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS
    • Théberge J., Al-Semaan Y., Williamson P.C., Menon R.S., Neufeld R.W., Rajakumar N., et al. Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS. Am J Psychiatry 160 (2003) 2231-2233
    • (2003) Am J Psychiatry , vol.160 , pp. 2231-2233
    • Théberge, J.1    Al-Semaan, Y.2    Williamson, P.C.3    Menon, R.S.4    Neufeld, R.W.5    Rajakumar, N.6
  • 46
    • 0035693652 scopus 로고    scopus 로고
    • Tissue shrinkage and unbiased stereological estimation of particle number and size
    • Dorph-Petersen K.A., Nyengaard J.R., and Gundersen H.J.G. Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 204 (2001) 232-246
    • (2001) J Microsc , vol.204 , pp. 232-246
    • Dorph-Petersen, K.A.1    Nyengaard, J.R.2    Gundersen, H.J.G.3
  • 47
    • 23744509784 scopus 로고    scopus 로고
    • The use of fluorescent probes in cell-counting procedures
    • Evans S.M., Janson A.M., and Nyengaard J.R. (Eds), Oxford University Press, Oxford
    • Peterson D.A. The use of fluorescent probes in cell-counting procedures. In: Evans S.M., Janson A.M., and Nyengaard J.R. (Eds). Quantitative Methods in Neuroscience (2004), Oxford University Press, Oxford 86-114
    • (2004) Quantitative Methods in Neuroscience , pp. 86-114
    • Peterson, D.A.1


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