Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder

Biological Psychiatry

Volumn 66, Issue 5, 2009, Pages 516-521

  Wang, Fei ^a,b   Kalmar, Jessica H ^a,b   He, Yong ^c,f   Jackowski, Marcel ^a,d   Chepenik, Lara G ^a,b   Edmiston, Elliot Kale ^a   Tie, Karen ^a,b   Gong, Gaolang ^e   Shah, Maulik P ^a,b   Jones, Monique ^a   Uderman, Jodi ^a   Constable, R Todd ^a   Blumberg, Hilary P ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c BEIJING NORMAL UNIVERSITY   (China)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e UNIVERSITY OF ALBERTA   (Canada)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

Amygdala; anterior cingulate cortex; bipolar disorder; diffusion tensor imaging; fMRI; functional connectivity; magnetic resonance imaging

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ANISOTROPY; ARTICLE; BIPOLAR DISORDER; BRAIN FUNCTION; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; FACE; FEAR; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAY MATTER; HAPPINESS; HUMAN; MALE; MORPHOLOGY; PRIORITY JOURNAL; THALAMOCORTICAL TRACT; VISUAL STIMULATION; WHITE MATTER;

EID: 68049139268     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.03.023     Document Type: Article

References (50)

1. Amaral D.G., and Price J.L. Amygdalocortical projections in the monkey (Macaca fascicularis). J Comp Neurol 230 (1984) 465-496
2. Pandya D.N., Van Hoesen G.W., and Mesulam M.M. Efferent connections of the cingulate gyrus in the rhesus monkey. Exp Brain Res 42 (1981) 319-330
3. Etkin A., Egner T., Peraza D.M., Kandel E.R., and Hirsch J. Resolving emotional conflict: A role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 51 (2006) 871-882
4. Blumberg H.P., Donegan N.H., Sanislow C.A., Collins S., Lacadie C., Skudlarski P., et al. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology 183 (2005) 308-313
5. Pavuluri M.N., O'Connor M.M., Harral E.M., and Sweeney J.A. An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Res 162 (2008) 244-255
6. Drevets W.C., Price J.L., Simpson Jr. J.R., Todd R.D., Reich T., Vannier M., et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386 (1997) 824-827
7. Kaur S., Sassi R.B., Axelson D., Nicoletti M., Brambilla P., Monkul E.S., et al. Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. Am J Psychiatry 162 (2005) 1637-1643
8. Blumberg H.P., Fredericks C., Wang F., Kalmar J.H., Spencer L., Papademetris X., et al. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disord 7 (2005) 570-576
9. Chang K., Adleman N.E., Dienes K., Simeonova D.I., Menon V., and Reiss A. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: A functional magnetic resonance imaging investigation. Arch Gen Psychiatry 61 (2004) 781-792
10. Altshuler L., Bookheimer S., Proenza M.A., Townsend J., Sabb F., Firestine A., et al. Increased amygdala activation during mania: A functional magnetic resonance imaging study. Am J Psychiatry 162 (2005) 1211-1213
11. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 8 (2005) 828-834
12. McIntosh A.M., Moorhead T.W., Job D., Lymer G.K., Munoz Maniega S., McKirdy J., et al. The effects of a neuregulin 1 variant on white matter density and integrity. Mol Psychiatry 13 (2008) 1054-1059
13. Roy K., Murtie J.C., El-Khodor B.F., Edgar N., Sardi S.P., Hooks B.M., et al. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc Natl Acad Sci U S A 104 (2007) 8131-8136
14. Ongur D., Drevets W.C., and Price J.L. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A 95 (1998) 13290-13295
15. Tkachev D., Mimmack M.L., Ryan M.M., Wayland M., Freeman T., Jones P.B., et al. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 362 (2003) 798-805
16. Uranova N.A., Vostrikov V.M., Orlovskaya D.D., and Rachmanova V.I. Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: A study from the Stanley Neuropathology Consortium. Schizophr Res 67 (2004) 269-275
17. Rajkowska G. Cell pathology in mood disorders. Semin Clin Neuropsychiatr 7 (2002) 281-292
18. Kieseppa T., van Erp T.G., Haukka J., Partonen T., Cannon T.D., Poutanen V.P., et al. Reduced left hemispheric white matter volume in twins with bipolar I disorder. Biol Psychiatry 54 (2003) 896-905
19. Beyer J.L., Taylor W.D., MacFall J.R., Kuchibhatla M., Payne M.E., Provenzale J.M., et al. Cortical white matter microstructural abnormalities in bipolar disorder. Neuropsychopharmacology 30 (2005) 2225-2229
20. Adler C.M., Holland S.K., Schmithorst V., Wilke M., Weiss K.L., Pan H., et al. Abnormal frontal white matter tracts in bipolar disorder: A diffusion tensor imaging study. Bipolar Disord 6 (2004) 197-203
21. Basser P.J., Mattiello J., and LeBihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 103 (1994) 247-254
22. Beaulieu C. The basis of anisotropic water diffusion in the nervous system-A technical review. NMR Biomed 15 (2002) 435-455
23. Wahl M., Lauterbach-Soon B., Hattingen E., Jung P., Singer O., Volz S., et al. Human motor corpus callosum: Topography, somatotopy, and link between microstructure and function. J Neurosci 27 (2007) 12132-12138
24. Rocca M.A., Pagani E., Absinta M., Valsasina P., Falini A., Scotti G., et al. Altered functional and structural connectivities in patients with MS: A 3-T study. Neurology 69 (2007) 2136-2145
25. Petrides M., and Pandya D.N. Efferent association pathways from the rostral prefrontal cortex in the macaque monkey. J Neurosci 27 (2007) 11573-11586
26. Schmahmann J.D., and Pandya D.N. Fiber Pathways of the Brain (2006), Oxford University Press, New York
27. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I & II Disorders (1995), New York State Psychiatric Institute, New York (Version 2.0).
28. Williams J.B.W., Link M.J., Rosenthal N.E., and Terman M. Structured Interview Guide for the Hamilton Depression Rating Scale: Seasonal Affective Disorder Version (SIGH-SAD) (1994), New York State Psychiatric Institute, New York
29. Altman E.G., Hedeker D.R., Janicak P.G., Peterson J.L., and Davis J.M. The Clinician-Administered Rating Scale for Mania (CARS-M): Development, reliability, and validity. Biol Psychiatry 36 (1994) 124-134
30. Shah M.P., Wang F., Kalmar J.H., Chepenik L.G., Tie K., Pittman B., et al. Role of variation in the serotonin transporter protein gene (SLC6A4) in trait disturbances in the ventral anterior cingulate in bipolar disorder. Neuropsychopharmacology 34 (2009) 1301-1310
31. Bush G., Luu P., and Posner M.I. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4 (2000) 215-222
32. Wang L., Zang Y., He Y., Liang M., Zhang X., Tian L., et al. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI. Neuroimage 31 (2006) 496-504
33. Lowe M.J., Mock B.J., and Sorenson J.A. Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations. Neuroimage 7 (1998) 119-132
34. Press W.H., Flannery B.P., Teukolsky S.A., and Vetterling W.T. Numerical Recipes in C: The Art of Scientific Computing (1992), Cambridge University Press, New York
35. Basser P.J., and Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111 (1996) 209-219
36. Quirk G.J., and Beer J.S. Prefrontal involvement in the regulation of emotion: Convergence of rat and human studies. Curr Opin Neurobiol 16 (2006) 723-727
37. Quirk G.J., Likhtik E., Pelletier J.G., and Pare D. Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J Neurosci 23 (2003) 8800-8807
38. Lawrie S.M., Buechel C., Whalley H.C., Frith C.D., Friston K.J., and Johnstone E.C. Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 51 (2002) 1008-1011
39. Houenou J., Wessa M., Douaud G., Leboyer M., Chanraud S., Perrin M., et al. Increased white matter connectivity in euthymic bipolar patients: Diffusion tensor tractography between the subgenual cingulate and the amygdalohippocampal complex. Mol Psychiatry 12 (2007) 1001-1010
40. Phillips M.L., Medford N., Young A.W., Williams L., Williams S.C., Bullmore E.T., et al. Time courses of left and right amygdalar responses to fearful facial expressions. Hum Brain Mapp 12 (2001) 193-202
41. Breiter H.C., Etcoff N.L., Whalen P.J., Kennedy W.A., Rauch S.L., Buckner R.L., et al. Response and habituation of the human amygdala during visual processing of facial expression. Neuron 17 (1996) 875-887
42. Morris J.S., Frith C.D., Perrett D.I., Rowland D., Young A.W., Calder A.J., et al. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 383 (1996) 812-815
43. Fudge J.L., and Emiliano A.B. The extended amygdala and the dopamine system: Another piece of the dopamine puzzle. J Neuropsychiatr Clin Neurosci 15 (2003) 306-316
44. Wessa M., Houenou J., Paillere-Martinot M.L., Berthoz S., Artiges E., Leboyer M., et al. Frontostriatal overactivation in euthymic bipolar patients during an emotional go/nogo task. Am J Psychiatry 164 (2007) 638-646
45. Hwang J., Lyoo I.K., Dager S.R., Friedman S.D., Oh J.S., Lee J.Y., et al. Basal ganglia shape alterations in bipolar disorder. Am J Psychiatry 163 (2006) 276-285
46. Beyer J.L., Kuchibhatla M., Payne M., Moo-Young M., Cassidy F., MacFall J., et al. Caudate volume measurement in older adults with bipolar disorder. Int J Geriatr Psychiatry 19 (2004) 109-114
47. Phillips M.L., Drevets W.C., Rauch S.L., and Lane R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry 54 (2003) 515-528
48. Foland L.C., Altshuler L.L., Bookheimer S.Y., Eisenberger N., Townsend J., and Thompson P.M. Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Res 162 (2008) 27-37
49. Rich B.A., Fromm S.J., Berghorst L.H., Dickstein D.P., Brotman M.A., Pine D.S., et al. Neural connectivity in children with bipolar disorder: Impairment in the face emotion processing circuit. J Child Psychol Psychiatry 49 (2008) 88-96
50. Cunningham M.G., Bhattacharyya S., and Benes F.M. Amygdalocortical sprouting continues into early adulthood: Implications for the development of normal and abnormal function during adolescence. J Comp Neurol 453 (2002) 116-130