Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity

Journal of Pharmaceutical Sciences

Volumn 103, Issue 2, 2014, Pages 602-612

  Ahmed, Osama A A ^a   Badr Eldin, Shaimaa M ^b   Tawfik, Mona K ^c   Ahmed, Tarek A ^d   El Say, Khalid M ^d   Badr, Jihan M ^e  

^a Minia University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c Suez Canal University Faculty of Medicine   (Egypt)

^d Al Azhar University   (Egypt)

^e Suez Canal University   (Egypt)

Author keywords

Dynamic light scattering; Emulsion; Hepatoprotective activity; Mixture design; Nanoparticles; Nanotechnology; Optical activity; Quercetin; SNEDDS

Indexed keywords

ALCOHOL; CARBOXYMETHYLCELLULOSE; CATALASE; GLUTATHIONE; LINOLEIC ACID; LIPID PEROXIDE; LIVER PROTECTIVE AGENT; MACROGOL 200; MACROGOL 400; MACROGOL 4000; MACROGOL 6000; MYRISTIC ACID ISOPROPYL ESTER; NANOCARRIER; OIL; OLEIC ACID; PARACETAMOL; POLYSORBATE 60; POLYSORBATE 80; PROPANOL; PROPYLENE GLYCOL; QUERCETIN; SILYMARIN; SORBITAN OLEATE; SUPEROXIDE DISMUTASE; SURFACTANT; TRIACETIN;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SOLUBILITY; EMULSION; ENZYME ACTIVITY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIVER FUNCTION TEST; LIVER PROTECTION; LIVER TOXICITY; MALE; NANOEMULSION; NONHUMAN; OXIDATION REDUCTION REACTION; RAT; SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM;

DYNAMIC LIGHT SCATTERING; EMULSION; HEPATOPROTECTIVE ACTIVITY; MIXTURE DESIGN; NANOPARTICLES; NANOTECHNOLOGY; OPTICAL ACTIVITY; QUERCETIN; SNEDDS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG-INDUCED LIVER INJURY; EMULSIONS; LIPID PEROXIDATION; LIVER FUNCTION TESTS; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYSORBATES; PROTECTIVE AGENTS; QUERCETIN; RATS; SILYMARIN; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; SURFACE-ACTIVE AGENTS;

EID: 84895920957     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23834     Document Type: Article

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